Cell‐penetrating peptides for cancer treatment: Current state and future directions
Abstract How to efficiently deliver therapeutic agents into cancer cells is a knotty problem for researchers. Over the past 30 years, the use of cell‐penetrating peptides (CPPs) to facilitate intracellular cargo delivery has received extensive attention. Encouraged by their robust membrane permeabil...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | Clinical and Translational Discovery |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ctd2.63 |
| _version_ | 1797945478403325952 |
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| author | Yuxin Guo Fu‐Gen Wu |
| author_facet | Yuxin Guo Fu‐Gen Wu |
| author_sort | Yuxin Guo |
| collection | DOAJ |
| description | Abstract How to efficiently deliver therapeutic agents into cancer cells is a knotty problem for researchers. Over the past 30 years, the use of cell‐penetrating peptides (CPPs) to facilitate intracellular cargo delivery has received extensive attention. Encouraged by their robust membrane permeability and satisfactory biocompatibility, various CPPs have been applied to construct anticancer drugs. However, owing to some unsolved problems, such as lack of cell selectively, short circulation time, and poor in vivo stability, no CPP has been approved by the Food and Drug Administration so far. Thus, further efforts are urgently needed to solve these problems. In this commentary, we discuss the current state and future directions of CPPs in the field of cancer therapy. |
| first_indexed | 2024-04-10T20:55:45Z |
| format | Article |
| id | doaj.art-8c95ec0945854921a8ba4d5369275146 |
| institution | Directory Open Access Journal |
| issn | 2768-0622 |
| language | English |
| last_indexed | 2024-04-10T20:55:45Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Discovery |
| spelling | doaj.art-8c95ec0945854921a8ba4d53692751462023-01-23T05:21:29ZengWileyClinical and Translational Discovery2768-06222022-06-0122n/an/a10.1002/ctd2.63Cell‐penetrating peptides for cancer treatment: Current state and future directionsYuxin Guo0Fu‐Gen Wu1State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing P. R. ChinaState Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing P. R. ChinaAbstract How to efficiently deliver therapeutic agents into cancer cells is a knotty problem for researchers. Over the past 30 years, the use of cell‐penetrating peptides (CPPs) to facilitate intracellular cargo delivery has received extensive attention. Encouraged by their robust membrane permeability and satisfactory biocompatibility, various CPPs have been applied to construct anticancer drugs. However, owing to some unsolved problems, such as lack of cell selectively, short circulation time, and poor in vivo stability, no CPP has been approved by the Food and Drug Administration so far. Thus, further efforts are urgently needed to solve these problems. In this commentary, we discuss the current state and future directions of CPPs in the field of cancer therapy.https://doi.org/10.1002/ctd2.63anticancercell‐penetrating peptidecellular uptakedrug deliverynanomedicine |
| spellingShingle | Yuxin Guo Fu‐Gen Wu Cell‐penetrating peptides for cancer treatment: Current state and future directions Clinical and Translational Discovery anticancer cell‐penetrating peptide cellular uptake drug delivery nanomedicine |
| title | Cell‐penetrating peptides for cancer treatment: Current state and future directions |
| title_full | Cell‐penetrating peptides for cancer treatment: Current state and future directions |
| title_fullStr | Cell‐penetrating peptides for cancer treatment: Current state and future directions |
| title_full_unstemmed | Cell‐penetrating peptides for cancer treatment: Current state and future directions |
| title_short | Cell‐penetrating peptides for cancer treatment: Current state and future directions |
| title_sort | cell penetrating peptides for cancer treatment current state and future directions |
| topic | anticancer cell‐penetrating peptide cellular uptake drug delivery nanomedicine |
| url | https://doi.org/10.1002/ctd2.63 |
| work_keys_str_mv | AT yuxinguo cellpenetratingpeptidesforcancertreatmentcurrentstateandfuturedirections AT fugenwu cellpenetratingpeptidesforcancertreatmentcurrentstateandfuturedirections |