Middle-Inner Macular Layers Dysfunction in a Case of Stellate Foveomacular Retinoschisis Detected by Abnormal Multifocal Photopic Negative Response Recordings
We describe the macular morpho-functional assessment of a 65-year-old man affected by stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR), studied by visual field, SD-OCT, autofluorescence, full-field electroretinogram (ffERG), multifocal electroretinogram (mfERG) and multifocal Pho...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/12/11/2753 |
| _version_ | 1797468582427230208 |
|---|---|
| author | Lucilla Barbano Giulio Antonelli Mariacristina Parravano Eliana Costanzo Vincenzo Parisi Lucia Ziccardi |
| author_facet | Lucilla Barbano Giulio Antonelli Mariacristina Parravano Eliana Costanzo Vincenzo Parisi Lucia Ziccardi |
| author_sort | Lucilla Barbano |
| collection | DOAJ |
| description | We describe the macular morpho-functional assessment of a 65-year-old man affected by stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR), studied by visual field, SD-OCT, autofluorescence, full-field electroretinogram (ffERG), multifocal electroretinogram (mfERG) and multifocal Photopic Negative Response (mfPhNR) recordings. The typical presentation consists of the foveal appearance of radial cartwheel pattern for the splitting of the retinal layers at the level of the Henle fiber layer (HFL) and the outer plexiform layer (OPL), perfectly seen by Spectral Domain-Optical Coherence Tomography (SD-OCT). Despite a normal function of the outer retina of the peripheral and central retina evaluated by ffERG and mfERG respectively, we observed a reduced function of the retinal elements involved in the retinoschisis by recording mfPhNR that assesses mainly inner retina function (retinal ganglion cells and their axons). Therefore, it is likely that the observed impaired mfPhNR responses reflect the signaling defects derived from the delaminated middle retina and transmitted to the innermost retinal layers. |
| first_indexed | 2024-03-09T19:09:29Z |
| format | Article |
| id | doaj.art-8c963b9831ca4e3a8d787ed13896d050 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T19:09:29Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-8c963b9831ca4e3a8d787ed13896d0502023-11-24T04:20:27ZengMDPI AGDiagnostics2075-44182022-11-011211275310.3390/diagnostics12112753Middle-Inner Macular Layers Dysfunction in a Case of Stellate Foveomacular Retinoschisis Detected by Abnormal Multifocal Photopic Negative Response RecordingsLucilla Barbano0Giulio Antonelli1Mariacristina Parravano2Eliana Costanzo3Vincenzo Parisi4Lucia Ziccardi5IRCCS—Fondazione Bietti, Via Livenza 1, 00198 Rome, ItalyIRCCS—Fondazione Bietti, Via Livenza 1, 00198 Rome, ItalyIRCCS—Fondazione Bietti, Via Livenza 1, 00198 Rome, ItalyIRCCS—Fondazione Bietti, Via Livenza 1, 00198 Rome, ItalyIRCCS—Fondazione Bietti, Via Livenza 1, 00198 Rome, ItalyIRCCS—Fondazione Bietti, Via Livenza 1, 00198 Rome, ItalyWe describe the macular morpho-functional assessment of a 65-year-old man affected by stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR), studied by visual field, SD-OCT, autofluorescence, full-field electroretinogram (ffERG), multifocal electroretinogram (mfERG) and multifocal Photopic Negative Response (mfPhNR) recordings. The typical presentation consists of the foveal appearance of radial cartwheel pattern for the splitting of the retinal layers at the level of the Henle fiber layer (HFL) and the outer plexiform layer (OPL), perfectly seen by Spectral Domain-Optical Coherence Tomography (SD-OCT). Despite a normal function of the outer retina of the peripheral and central retina evaluated by ffERG and mfERG respectively, we observed a reduced function of the retinal elements involved in the retinoschisis by recording mfPhNR that assesses mainly inner retina function (retinal ganglion cells and their axons). Therefore, it is likely that the observed impaired mfPhNR responses reflect the signaling defects derived from the delaminated middle retina and transmitted to the innermost retinal layers.https://www.mdpi.com/2075-4418/12/11/2753SNIFRPhNRretinoschisisinner retinaelectroretinogram |
| spellingShingle | Lucilla Barbano Giulio Antonelli Mariacristina Parravano Eliana Costanzo Vincenzo Parisi Lucia Ziccardi Middle-Inner Macular Layers Dysfunction in a Case of Stellate Foveomacular Retinoschisis Detected by Abnormal Multifocal Photopic Negative Response Recordings Diagnostics SNIFR PhNR retinoschisis inner retina electroretinogram |
| title | Middle-Inner Macular Layers Dysfunction in a Case of Stellate Foveomacular Retinoschisis Detected by Abnormal Multifocal Photopic Negative Response Recordings |
| title_full | Middle-Inner Macular Layers Dysfunction in a Case of Stellate Foveomacular Retinoschisis Detected by Abnormal Multifocal Photopic Negative Response Recordings |
| title_fullStr | Middle-Inner Macular Layers Dysfunction in a Case of Stellate Foveomacular Retinoschisis Detected by Abnormal Multifocal Photopic Negative Response Recordings |
| title_full_unstemmed | Middle-Inner Macular Layers Dysfunction in a Case of Stellate Foveomacular Retinoschisis Detected by Abnormal Multifocal Photopic Negative Response Recordings |
| title_short | Middle-Inner Macular Layers Dysfunction in a Case of Stellate Foveomacular Retinoschisis Detected by Abnormal Multifocal Photopic Negative Response Recordings |
| title_sort | middle inner macular layers dysfunction in a case of stellate foveomacular retinoschisis detected by abnormal multifocal photopic negative response recordings |
| topic | SNIFR PhNR retinoschisis inner retina electroretinogram |
| url | https://www.mdpi.com/2075-4418/12/11/2753 |
| work_keys_str_mv | AT lucillabarbano middleinnermacularlayersdysfunctioninacaseofstellatefoveomacularretinoschisisdetectedbyabnormalmultifocalphotopicnegativeresponserecordings AT giulioantonelli middleinnermacularlayersdysfunctioninacaseofstellatefoveomacularretinoschisisdetectedbyabnormalmultifocalphotopicnegativeresponserecordings AT mariacristinaparravano middleinnermacularlayersdysfunctioninacaseofstellatefoveomacularretinoschisisdetectedbyabnormalmultifocalphotopicnegativeresponserecordings AT elianacostanzo middleinnermacularlayersdysfunctioninacaseofstellatefoveomacularretinoschisisdetectedbyabnormalmultifocalphotopicnegativeresponserecordings AT vincenzoparisi middleinnermacularlayersdysfunctioninacaseofstellatefoveomacularretinoschisisdetectedbyabnormalmultifocalphotopicnegativeresponserecordings AT luciaziccardi middleinnermacularlayersdysfunctioninacaseofstellatefoveomacularretinoschisisdetectedbyabnormalmultifocalphotopicnegativeresponserecordings |