The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review
RAS guanyl nucleotide-releasing proteins (RASGRPs) are important proteins that act as guanine nucleotide exchange factors, which activate small GTPases and function as molecular switches for intracellular signals. The RASGRP family is composed of RASGRP1–4 proteins and activates the small GTPases, R...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/20/11129 |
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| author | Jun-ichi Takino Shouhei Miyazaki Kentaro Nagamine Takamitsu Hori |
| author_facet | Jun-ichi Takino Shouhei Miyazaki Kentaro Nagamine Takamitsu Hori |
| author_sort | Jun-ichi Takino |
| collection | DOAJ |
| description | RAS guanyl nucleotide-releasing proteins (RASGRPs) are important proteins that act as guanine nucleotide exchange factors, which activate small GTPases and function as molecular switches for intracellular signals. The RASGRP family is composed of RASGRP1–4 proteins and activates the small GTPases, RAS and RAP. Among them, RASGRP2 has different characteristics from other RASGRPs in that it targets small GTPases and its localizations are different. Many studies related to RASGRP2 have been reported in cells of the blood cell lineage. Furthermore, RASGRP2 has also been reported to be associated with Huntington’s disease, tumors, and rheumatoid arthritis. In addition, we also recently reported RASGRP2 expression in vascular endothelial cells, and clarified the involvement of xenopus Rasgrp2 in the vasculogenesis process and multiple signaling pathways of RASGRP2 in human vascular endothelial cells with stable expression of RASGRP2. Therefore, this article outlines the existing knowledge of RASGRP2 and focuses on its expression and role in vascular endothelial cells, and suggests that RASGRP2 functions as a protective factor for maintaining healthy blood vessels. |
| first_indexed | 2024-03-10T06:30:54Z |
| format | Article |
| id | doaj.art-8c9789ee430749ed9d12af21442f6866 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T06:30:54Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8c9789ee430749ed9d12af21442f68662023-11-22T18:34:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-10-0122201112910.3390/ijms222011129The Role of RASGRP2 in Vascular Endothelial Cells—A Mini ReviewJun-ichi Takino0Shouhei Miyazaki1Kentaro Nagamine2Takamitsu Hori3Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, JapanFaculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, JapanFaculty of Health Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, JapanFaculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, JapanRAS guanyl nucleotide-releasing proteins (RASGRPs) are important proteins that act as guanine nucleotide exchange factors, which activate small GTPases and function as molecular switches for intracellular signals. The RASGRP family is composed of RASGRP1–4 proteins and activates the small GTPases, RAS and RAP. Among them, RASGRP2 has different characteristics from other RASGRPs in that it targets small GTPases and its localizations are different. Many studies related to RASGRP2 have been reported in cells of the blood cell lineage. Furthermore, RASGRP2 has also been reported to be associated with Huntington’s disease, tumors, and rheumatoid arthritis. In addition, we also recently reported RASGRP2 expression in vascular endothelial cells, and clarified the involvement of xenopus Rasgrp2 in the vasculogenesis process and multiple signaling pathways of RASGRP2 in human vascular endothelial cells with stable expression of RASGRP2. Therefore, this article outlines the existing knowledge of RASGRP2 and focuses on its expression and role in vascular endothelial cells, and suggests that RASGRP2 functions as a protective factor for maintaining healthy blood vessels.https://www.mdpi.com/1422-0067/22/20/11129RAS guanyl nucleotide-releasing protein 2 (RASGRP2)vascular endothelial cellssmall GTPaseRAP1R-RAS |
| spellingShingle | Jun-ichi Takino Shouhei Miyazaki Kentaro Nagamine Takamitsu Hori The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review International Journal of Molecular Sciences RAS guanyl nucleotide-releasing protein 2 (RASGRP2) vascular endothelial cells small GTPase RAP1 R-RAS |
| title | The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review |
| title_full | The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review |
| title_fullStr | The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review |
| title_full_unstemmed | The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review |
| title_short | The Role of RASGRP2 in Vascular Endothelial Cells—A Mini Review |
| title_sort | role of rasgrp2 in vascular endothelial cells a mini review |
| topic | RAS guanyl nucleotide-releasing protein 2 (RASGRP2) vascular endothelial cells small GTPase RAP1 R-RAS |
| url | https://www.mdpi.com/1422-0067/22/20/11129 |
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