Focal Segmental Glomerulosclerosis: A Single Center Experience
Aim: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerulonephritis (GNP) worldwide. Despite treatment, it may progress to end-stage renal disease. In the present study, we compared clinical and histopathological data on FSGS with primary and secondary GNP retrospectively. M...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2016-09-01
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| Series: | Haseki Tıp Bülteni |
| Subjects: | |
| Online Access: | http://www.hasekidergisi.com/article_10988/Focal-Segmental-Glomerulosclerosis-A-Single-Center-Experience |
| _version_ | 1797916442903969792 |
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| author | Yavuz Ayar Alparslan Ersoy Abdülmecit Yıldız Ayşegül Oruç Fatma Ezgi Can Gökhan Ocakoğlu Mustafa Güllülü Dilay Demirayak İsmail Bayrakçı Hakan Düger Tuğba Ocak Bayram Korkut Ahmet Bilgehan Şahin Mustafa Akan Eda Eylemer |
| author_facet | Yavuz Ayar Alparslan Ersoy Abdülmecit Yıldız Ayşegül Oruç Fatma Ezgi Can Gökhan Ocakoğlu Mustafa Güllülü Dilay Demirayak İsmail Bayrakçı Hakan Düger Tuğba Ocak Bayram Korkut Ahmet Bilgehan Şahin Mustafa Akan Eda Eylemer |
| author_sort | Yavuz Ayar |
| collection | DOAJ |
| description | Aim: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerulonephritis (GNP) worldwide. Despite treatment, it may progress to end-stage renal disease. In the present study, we compared clinical and histopathological data on FSGS with primary and secondary GNP retrospectively.
Methods: We retrospectively analyzed data on clinical and laboratory findings, treatment response, and risk factors associated with mortality in patients, who had been diagnosed with FSGS and other GNP via renal biopsy between January 2009 and December 2014. The average follow-up time was 22 (8-76) months.
Results: FSGS and primary GNP were more frequently seen in males than in females (55.9% vs. 65.3%, p=0.033). Nephrotic syndrome was more common in patients with FSGS (41.2%) and primary GNP (57.7%), while chronic renal disease was more frequent in patients with secondary GNP (35%). In FSGS, the complete remission rate was 54.4%. 63.2% of patients had continued to receive treatment. According to the biopsy findings, interstitial inflammation and fibrosis were observed in 100% and 98.5% of patients with FSGS, respectively (p=0.010 and p<0.001, respectively). Serum albumin level was found to be increased and proteinuria, total cholesterol, triglyceride, and LDL levels to be decreased after treatment (p<0.001). Serum creatinine levels and type of GNP (secondary GNP) were detected to be 1.48 and 8.14 fold increased in mortality analysis, respectively.
Conclusion: Renal biopsy is the gold standard for the diagnosis of glomerular diseases. Renal function at the time of diagnosis, follow-up and appropriate immunosuppressive therapy have effects on mortality and clinical progress in FSGS as is the case in all GNPs. |
| first_indexed | 2024-04-10T12:58:16Z |
| format | Article |
| id | doaj.art-8c99e500f5624c50ba6522760f470eed |
| institution | Directory Open Access Journal |
| issn | 1302-0072 2147-2688 |
| language | English |
| last_indexed | 2024-04-10T12:58:16Z |
| publishDate | 2016-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Haseki Tıp Bülteni |
| spelling | doaj.art-8c99e500f5624c50ba6522760f470eed2023-02-15T16:13:22ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882016-09-0154313714310.4274/haseki.2941Focal Segmental Glomerulosclerosis: A Single Center ExperienceYavuz Ayar0Alparslan Ersoy1Abdülmecit Yıldız2Ayşegül Oruç3Fatma Ezgi Can4Gökhan Ocakoğlu5Mustafa Güllülü6Dilay Demirayak7İsmail Bayrakçı8Hakan Düger9Tuğba Ocak10Bayram Korkut11Ahmet Bilgehan Şahin12Mustafa Akan13Eda Eylemer14Uludağ Üniversitesi Tıp Fakültesi, Nefroloji Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, Nefroloji Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, Nefroloji Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, Nefroloji Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, Nefroloji Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bursa, TürkiyeUludağ Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Bursa, TürkiyeAim: Focal segmental glomerulosclerosis (FSGS) is one of the most common glomerulonephritis (GNP) worldwide. Despite treatment, it may progress to end-stage renal disease. In the present study, we compared clinical and histopathological data on FSGS with primary and secondary GNP retrospectively. Methods: We retrospectively analyzed data on clinical and laboratory findings, treatment response, and risk factors associated with mortality in patients, who had been diagnosed with FSGS and other GNP via renal biopsy between January 2009 and December 2014. The average follow-up time was 22 (8-76) months. Results: FSGS and primary GNP were more frequently seen in males than in females (55.9% vs. 65.3%, p=0.033). Nephrotic syndrome was more common in patients with FSGS (41.2%) and primary GNP (57.7%), while chronic renal disease was more frequent in patients with secondary GNP (35%). In FSGS, the complete remission rate was 54.4%. 63.2% of patients had continued to receive treatment. According to the biopsy findings, interstitial inflammation and fibrosis were observed in 100% and 98.5% of patients with FSGS, respectively (p=0.010 and p<0.001, respectively). Serum albumin level was found to be increased and proteinuria, total cholesterol, triglyceride, and LDL levels to be decreased after treatment (p<0.001). Serum creatinine levels and type of GNP (secondary GNP) were detected to be 1.48 and 8.14 fold increased in mortality analysis, respectively. Conclusion: Renal biopsy is the gold standard for the diagnosis of glomerular diseases. Renal function at the time of diagnosis, follow-up and appropriate immunosuppressive therapy have effects on mortality and clinical progress in FSGS as is the case in all GNPs.http://www.hasekidergisi.com/article_10988/Focal-Segmental-Glomerulosclerosis-A-Single-Center-ExperienceFocal segmental glomerulosclerosisglomerulonephritisproteinuriarenal biopsy |
| spellingShingle | Yavuz Ayar Alparslan Ersoy Abdülmecit Yıldız Ayşegül Oruç Fatma Ezgi Can Gökhan Ocakoğlu Mustafa Güllülü Dilay Demirayak İsmail Bayrakçı Hakan Düger Tuğba Ocak Bayram Korkut Ahmet Bilgehan Şahin Mustafa Akan Eda Eylemer Focal Segmental Glomerulosclerosis: A Single Center Experience Haseki Tıp Bülteni Focal segmental glomerulosclerosis glomerulonephritis proteinuria renal biopsy |
| title | Focal Segmental Glomerulosclerosis: A Single Center Experience |
| title_full | Focal Segmental Glomerulosclerosis: A Single Center Experience |
| title_fullStr | Focal Segmental Glomerulosclerosis: A Single Center Experience |
| title_full_unstemmed | Focal Segmental Glomerulosclerosis: A Single Center Experience |
| title_short | Focal Segmental Glomerulosclerosis: A Single Center Experience |
| title_sort | focal segmental glomerulosclerosis a single center experience |
| topic | Focal segmental glomerulosclerosis glomerulonephritis proteinuria renal biopsy |
| url | http://www.hasekidergisi.com/article_10988/Focal-Segmental-Glomerulosclerosis-A-Single-Center-Experience |
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