EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263

EA.hy926 Cells and HUVECs Share Similar Senescence Phenotypes but Respond Differently to the Senolytic Drug ABT-263

Doxorubicin (DOX) induces endothelial cell (EC) senescence, which contributes to endothelial dysfunction and cardiovascular complications. Senolytic drugs selectively eliminate senescent cells to ameliorate senescence-mediated pathologies. Previous studies have demonstrated differences between immor...

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Bibliographic Details
Main Authors: Ibrahim Y. Abdelgawad, Kevin Agostinucci, Somia G. Ismail, Marianne K. O. Grant, Beshay N. Zordoky
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
endothelial cells
doxorubicin
senescence
senolytics
ABT-263
BCL-2 family
Online Access:https://www.mdpi.com/2073-4409/11/13/1992

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