Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators
Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.768133/full |
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| author | Javier Perez-Hernandez Javier Perez-Hernandez Valerio Chiurchiù Valerio Chiurchiù Sylvain Perruche Sylvain Perruche Sylvaine You |
| author_facet | Javier Perez-Hernandez Javier Perez-Hernandez Valerio Chiurchiù Valerio Chiurchiù Sylvain Perruche Sylvain Perruche Sylvaine You |
| author_sort | Javier Perez-Hernandez |
| collection | DOAJ |
| description | Both the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation and its resolution, polymorphonuclear cells (PMNs) and macrophages switch from producing pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving lipid mediators (SPMs), namely, lipoxins, resolvins, protectins, and maresins, which are operative at the local level to limit further inflammation and tissue injury and restore homeostasis. Accumulating evidences expand now the role and actions of these lipid mediators from innate to adaptive immunity. In particular, SPMs have been shown to contribute to the control of chronic inflammation, and alterations in their production and/or function have been associated with the persistence of several pathological conditions, including autoimmunity, in human and experimental models. In this review, we focus on the impact of pro-resolving lipids on T cells through their ability to modulate T-cell responses. In particular, the effects of the different families of SPMs to restrain effector T-cell functions while promoting regulatory T cells will be reviewed, along with the underlying mechanisms. Furthermore, the emerging concept of SPMs as new biological markers for disease diagnostic and progression and as putative therapeutic tools to regulate the development and magnitude of inflammatory and autoimmune diseases is discussed. |
| first_indexed | 2024-12-19T00:31:34Z |
| format | Article |
| id | doaj.art-8c9b52be948d4ead82a8151922b16622 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T00:31:34Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8c9b52be948d4ead82a8151922b166222022-12-21T20:45:05ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-11-011210.3389/fimmu.2021.768133768133Regulation of T-Cell Immune Responses by Pro-Resolving Lipid MediatorsJavier Perez-Hernandez0Javier Perez-Hernandez1Valerio Chiurchiù2Valerio Chiurchiù3Sylvain Perruche4Sylvain Perruche5Sylvaine You6Université de Paris, Institut Cochin, CNRS, Institut National de la Santé et de le Recherche Médicale (INSERM), Paris, FranceDepartament of Nutrition and Health, Valencian International University (VIU), Valencia, SpainInstitute of Translational Pharmacology, National Research Council, Rome, ItalyLaboratory of Resolution of Neuroinflammation, European Center for Brain Research, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Santa Lucia Foundation, Rome, ItalyUniversité de Bourgogne Franche-Comté, INSERM, Etablissement Français du Sang (EFS) Bourgogne-Franche Comté (BFC), Unité Mixte de Recherche (UMR)1098 Research on Interaction between Graft, Host and Tumor (RIGHT), Interactions Hôte Greffon-Tumeur/Ingénierie Cellulaire et Génique, Fédération Hospitalo-Universitaire Integrated Center for REsearch in inflammatory diseASes (InCREASe), Besançon, FranceMED’INN’Pharma, Besançon, FranceUniversité de Paris, Institut Cochin, CNRS, Institut National de la Santé et de le Recherche Médicale (INSERM), Paris, FranceBoth the initiation and the resolution of inflammatory responses are governed by the sequential activation, migration, and control/suppression of immune cells at the site of injury. Bioactive lipids play a major role in the fine-tuning of this dynamic process in a timely manner. During inflammation and its resolution, polymorphonuclear cells (PMNs) and macrophages switch from producing pro-inflammatory prostaglandins and leukotrienes to specialized pro-resolving lipid mediators (SPMs), namely, lipoxins, resolvins, protectins, and maresins, which are operative at the local level to limit further inflammation and tissue injury and restore homeostasis. Accumulating evidences expand now the role and actions of these lipid mediators from innate to adaptive immunity. In particular, SPMs have been shown to contribute to the control of chronic inflammation, and alterations in their production and/or function have been associated with the persistence of several pathological conditions, including autoimmunity, in human and experimental models. In this review, we focus on the impact of pro-resolving lipids on T cells through their ability to modulate T-cell responses. In particular, the effects of the different families of SPMs to restrain effector T-cell functions while promoting regulatory T cells will be reviewed, along with the underlying mechanisms. Furthermore, the emerging concept of SPMs as new biological markers for disease diagnostic and progression and as putative therapeutic tools to regulate the development and magnitude of inflammatory and autoimmune diseases is discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2021.768133/fullresolutionadaptive immunityautoimmunityT celltherapyspecialized pro-resolving lipid mediators (SPMs) |
| spellingShingle | Javier Perez-Hernandez Javier Perez-Hernandez Valerio Chiurchiù Valerio Chiurchiù Sylvain Perruche Sylvain Perruche Sylvaine You Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators Frontiers in Immunology resolution adaptive immunity autoimmunity T cell therapy specialized pro-resolving lipid mediators (SPMs) |
| title | Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators |
| title_full | Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators |
| title_fullStr | Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators |
| title_full_unstemmed | Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators |
| title_short | Regulation of T-Cell Immune Responses by Pro-Resolving Lipid Mediators |
| title_sort | regulation of t cell immune responses by pro resolving lipid mediators |
| topic | resolution adaptive immunity autoimmunity T cell therapy specialized pro-resolving lipid mediators (SPMs) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.768133/full |
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