Single-Cell RNA Sequencing (scRNA-seq) Identifies L1CAM as a Key Mediator between Epithelial Tuft Cell and Innate Lymphoid Cell in the Colon of <i>Hnrnp I</i> Knockout Mice

Single-Cell RNA Sequencing (scRNA-seq) Identifies L1CAM as a Key Mediator between Epithelial Tuft Cell and Innate Lymphoid Cell in the Colon of <i>Hnrnp I</i> Knockout Mice

(1) Background: Knockout (KO) of heterogeneous nuclear ribonucleoprotein I (<i>Hnrnp I</i>) in mouse intestinal epithelial cells (IECs) induced a severe inflammatory response in the colon, followed by hyperproliferation. This study aimed to investigate the epithelial lineage dynamics and...

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Bibliographic Details
Main Authors: Guanying (Bianca) Xu, Yuan-Xiang Pan, Wenyan Mei, Hong Chen
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Biomedicines
Subjects:
tuft
ILCs
L1CAM
colon
inflammation
colitis
Online Access:https://www.mdpi.com/2227-9059/11/10/2734

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