No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Although zinc (Zn) was reported to have antioxidant, anti-inflammatory and protective properties in CVDs, its association with coronary artery disease (CAD) is still unclear. As methods commonly used to assess Zn levels in bloo...
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MDPI AG
2022-06-01
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| Series: | Biomolecules |
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| author | Ewelina A. Dziedzic Jakub S. Gąsior Agnieszka Tuzimek Justyna Paleczny Mirosław Kwaśny Marek Dąbrowski Piotr Jankowski |
| author_facet | Ewelina A. Dziedzic Jakub S. Gąsior Agnieszka Tuzimek Justyna Paleczny Mirosław Kwaśny Marek Dąbrowski Piotr Jankowski |
| author_sort | Ewelina A. Dziedzic |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Although zinc (Zn) was reported to have antioxidant, anti-inflammatory and protective properties in CVDs, its association with coronary artery disease (CAD) is still unclear. As methods commonly used to assess Zn levels in blood and urine do not show the full picture of the microelement supply, in this study, the nutritional status of Zn in patients with angiographically confirmed CAD was assessed using inductively coupled plasma optical emission spectrometry. We found no association between Zn and the severity of CAD evaluated with the Coronary Artery Surgery Study Score (<i>p</i> = 0.67). There were no statistically significant differences in Zn levels between patients with acute coronary syndrome and those with stable CAD (<i>p</i> = 0.937). A statically significant negative correlation was observed between Zn content and serum triglyceride concentration (<i>p</i> < 0.05). Patients with type 2 diabetes mellitus were found to have a significantly lower hair Zn content compared to non-diabetic individuals (<i>p</i> < 0.01). The role of Zn in the pathogenesis of CAD and its complications need further well-designed research as the moderation and supplementation of Zn dietary intake could be a simple intervention to reduce the CVDs risk. |
| first_indexed | 2024-03-09T03:40:33Z |
| format | Article |
| id | doaj.art-8c9bcde6bdd043f88f5b44705d4cb09f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T03:40:33Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-8c9bcde6bdd043f88f5b44705d4cb09f2023-12-03T14:41:42ZengMDPI AGBiomolecules2218-273X2022-06-0112786210.3390/biom12070862No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary SyndromesEwelina A. Dziedzic0Jakub S. Gąsior1Agnieszka Tuzimek2Justyna Paleczny3Mirosław Kwaśny4Marek Dąbrowski5Piotr Jankowski6Medical Faculty, Lazarski University in Warsaw, 02-662 Warsaw, PolandDepartment of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandDepartment of Pharmaceutical Microbiology and Parasitology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, PolandInstitute of Optoelectronics, Military University of Technology, 00-908 Warsaw, PolandDepartment of Cardiology, Bielanski Hospital, 01-809 Warsaw, PolandDepartment of Internal Medicine and Geriatric Cardiology, Centre of Postgraduate Medical Education, 01-813 Warsaw, PolandCardiovascular diseases (CVDs) are the leading cause of death worldwide. Although zinc (Zn) was reported to have antioxidant, anti-inflammatory and protective properties in CVDs, its association with coronary artery disease (CAD) is still unclear. As methods commonly used to assess Zn levels in blood and urine do not show the full picture of the microelement supply, in this study, the nutritional status of Zn in patients with angiographically confirmed CAD was assessed using inductively coupled plasma optical emission spectrometry. We found no association between Zn and the severity of CAD evaluated with the Coronary Artery Surgery Study Score (<i>p</i> = 0.67). There were no statistically significant differences in Zn levels between patients with acute coronary syndrome and those with stable CAD (<i>p</i> = 0.937). A statically significant negative correlation was observed between Zn content and serum triglyceride concentration (<i>p</i> < 0.05). Patients with type 2 diabetes mellitus were found to have a significantly lower hair Zn content compared to non-diabetic individuals (<i>p</i> < 0.01). The role of Zn in the pathogenesis of CAD and its complications need further well-designed research as the moderation and supplementation of Zn dietary intake could be a simple intervention to reduce the CVDs risk.https://www.mdpi.com/2218-273X/12/7/862zinccoronary artery diseasemyocardial infarctionacute coronary syndrome |
| spellingShingle | Ewelina A. Dziedzic Jakub S. Gąsior Agnieszka Tuzimek Justyna Paleczny Mirosław Kwaśny Marek Dąbrowski Piotr Jankowski No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes Biomolecules zinc coronary artery disease myocardial infarction acute coronary syndrome |
| title | No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes |
| title_full | No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes |
| title_fullStr | No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes |
| title_full_unstemmed | No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes |
| title_short | No Association of Hair Zinc Concentration with Coronary Artery Disease Severity and No Relation with Acute Coronary Syndromes |
| title_sort | no association of hair zinc concentration with coronary artery disease severity and no relation with acute coronary syndromes |
| topic | zinc coronary artery disease myocardial infarction acute coronary syndrome |
| url | https://www.mdpi.com/2218-273X/12/7/862 |
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