The association between obesity indicators and metabolic risk factors in type-2 diabetic patients
Rationale and objectives: Obesity, accumulation of adipose tissue, is a global disease that can lead to cardiovascular and metabolic complications. The aim of this study was to investigate the relationship between obesity indicators and metabolic risk factors in type 2 diabetes mellitus (T2DM) patie...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023072213 |
| _version_ | 1797669781604663296 |
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| author | Sunan Xu Ruichen Ren Wenting Li Yongfeng Liang Junqing Ma Yongze Zheng Wei Zhao Yu Ma Tao Zhou Yang Zhang |
| author_facet | Sunan Xu Ruichen Ren Wenting Li Yongfeng Liang Junqing Ma Yongze Zheng Wei Zhao Yu Ma Tao Zhou Yang Zhang |
| author_sort | Sunan Xu |
| collection | DOAJ |
| description | Rationale and objectives: Obesity, accumulation of adipose tissue, is a global disease that can lead to cardiovascular and metabolic complications. The aim of this study was to investigate the relationship between obesity indicators and metabolic risk factors in type 2 diabetes mellitus (T2DM) patients. Materials and methods: A total of 337 T2DM subjects were included in our study. The metabolic risk factors including diabetes duration, fast plasma glucose (FPG), height, weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), estimated average glucose (eAG), glycated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), triglyceride (TG), blood urea nitrogen (BUN), serum creatinine (Scr), free fatty acid (FFA), uric acid (UA), cystatin c (cysc), albumin (Alb), urinary albumin creatinine ratio (UACR) were recorded. The obesity indicators included body surface area (BSA), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), para-perirenal fat thickness (PRFT), total abdominal fat (TAF), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT). The association between obesity indicators and metabolic risk factors was investigated by univariate and multivariate analysis. Results: HDL-c was independently associated with WHR and PRFT (β = −0.126 vs. −0.214, both p < 0.05). TG and Scr were both independently associated with PRFT (β = 0.173 vs. 0.218, both p < 0.01, respectively). UA was independently associated with BSA (β = 0.172, p < 0.01) and PRFT (β = 0.151, p < 0.01). cysc, Alb and UACR were independently associated with WC (β = 0.274 vs. 0.204 vs. 0.182, all p < 0.01). Conclusion: In T2DM patients, obesity indicators were significantly associated with metabolic risk factors. |
| first_indexed | 2024-03-11T20:49:43Z |
| format | Article |
| id | doaj.art-8c9bfac082cd45458f9bd47be611d8be |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:49:43Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-8c9bfac082cd45458f9bd47be611d8be2023-10-01T06:02:15ZengElsevierHeliyon2405-84402023-09-0199e20013The association between obesity indicators and metabolic risk factors in type-2 diabetic patientsSunan Xu0Ruichen Ren1Wenting Li2Yongfeng Liang3Junqing Ma4Yongze Zheng5Wei Zhao6Yu Ma7Tao Zhou8Yang Zhang9Department of Radiology, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Radiology, Shandong Rongjun General Hospital, Jinan, ChinaDepartment of Radiology, Tai'an First People's Hospital, Tai'an, Shandong, ChinaDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China; Corresponding author.Rationale and objectives: Obesity, accumulation of adipose tissue, is a global disease that can lead to cardiovascular and metabolic complications. The aim of this study was to investigate the relationship between obesity indicators and metabolic risk factors in type 2 diabetes mellitus (T2DM) patients. Materials and methods: A total of 337 T2DM subjects were included in our study. The metabolic risk factors including diabetes duration, fast plasma glucose (FPG), height, weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), estimated average glucose (eAG), glycated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), triglyceride (TG), blood urea nitrogen (BUN), serum creatinine (Scr), free fatty acid (FFA), uric acid (UA), cystatin c (cysc), albumin (Alb), urinary albumin creatinine ratio (UACR) were recorded. The obesity indicators included body surface area (BSA), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), para-perirenal fat thickness (PRFT), total abdominal fat (TAF), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT). The association between obesity indicators and metabolic risk factors was investigated by univariate and multivariate analysis. Results: HDL-c was independently associated with WHR and PRFT (β = −0.126 vs. −0.214, both p < 0.05). TG and Scr were both independently associated with PRFT (β = 0.173 vs. 0.218, both p < 0.01, respectively). UA was independently associated with BSA (β = 0.172, p < 0.01) and PRFT (β = 0.151, p < 0.01). cysc, Alb and UACR were independently associated with WC (β = 0.274 vs. 0.204 vs. 0.182, all p < 0.01). Conclusion: In T2DM patients, obesity indicators were significantly associated with metabolic risk factors.http://www.sciencedirect.com/science/article/pii/S2405844023072213ObesityMetabolic risk factorsDiabetes mellitus |
| spellingShingle | Sunan Xu Ruichen Ren Wenting Li Yongfeng Liang Junqing Ma Yongze Zheng Wei Zhao Yu Ma Tao Zhou Yang Zhang The association between obesity indicators and metabolic risk factors in type-2 diabetic patients Heliyon Obesity Metabolic risk factors Diabetes mellitus |
| title | The association between obesity indicators and metabolic risk factors in type-2 diabetic patients |
| title_full | The association between obesity indicators and metabolic risk factors in type-2 diabetic patients |
| title_fullStr | The association between obesity indicators and metabolic risk factors in type-2 diabetic patients |
| title_full_unstemmed | The association between obesity indicators and metabolic risk factors in type-2 diabetic patients |
| title_short | The association between obesity indicators and metabolic risk factors in type-2 diabetic patients |
| title_sort | association between obesity indicators and metabolic risk factors in type 2 diabetic patients |
| topic | Obesity Metabolic risk factors Diabetes mellitus |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023072213 |
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