CXCR2: From Bench to Bedside
Leukocyte recruitment to sites of infection or tissue damage plays a crucial role for the innate immune response. Chemokine-dependent signaling in immune cells is a very important mechanism leading to integrin activation and leukocyte recruitment. CXC-chemokine receptor 2 (CXCR2) is a prominent chem...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00263/full |
| _version_ | 1819294726994526208 |
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| author | Alex eZarbock Anika eStadtmann |
| author_facet | Alex eZarbock Anika eStadtmann |
| author_sort | Alex eZarbock |
| collection | DOAJ |
| description | Leukocyte recruitment to sites of infection or tissue damage plays a crucial role for the innate immune response. Chemokine-dependent signaling in immune cells is a very important mechanism leading to integrin activation and leukocyte recruitment. CXC-chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. During the last years, several studies were performed investigating the role of CXCR2 in different diseases. Until now, many CXCR2 inhibitors are tested in animal models and clinical trials and promising results were obtained. This review gives an overview of the structure of CXCR2 and the signaling pathways that are activated following CXCR2 stimulation. We discuss in detail the role of this chemokine receptor in different disease models including acute lung injury, COPD, sepsis, and ischemia-reperfusion-injury. Furthermore, this review summarizes the results of clinical trials which used CXCR2 inhibitors. |
| first_indexed | 2024-12-24T04:30:55Z |
| format | Article |
| id | doaj.art-8c9c34323c2e40ca9c46a1985caf99ff |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-24T04:30:55Z |
| publishDate | 2012-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8c9c34323c2e40ca9c46a1985caf99ff2022-12-21T17:15:25ZengFrontiers Media S.A.Frontiers in Immunology1664-32242012-08-01310.3389/fimmu.2012.0026325968CXCR2: From Bench to BedsideAlex eZarbock0Anika eStadtmann1University of MuensterUniversity of MuensterLeukocyte recruitment to sites of infection or tissue damage plays a crucial role for the innate immune response. Chemokine-dependent signaling in immune cells is a very important mechanism leading to integrin activation and leukocyte recruitment. CXC-chemokine receptor 2 (CXCR2) is a prominent chemokine receptor on neutrophils. During the last years, several studies were performed investigating the role of CXCR2 in different diseases. Until now, many CXCR2 inhibitors are tested in animal models and clinical trials and promising results were obtained. This review gives an overview of the structure of CXCR2 and the signaling pathways that are activated following CXCR2 stimulation. We discuss in detail the role of this chemokine receptor in different disease models including acute lung injury, COPD, sepsis, and ischemia-reperfusion-injury. Furthermore, this review summarizes the results of clinical trials which used CXCR2 inhibitors.http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00263/fullsignalingchemokine receptorLeukocyte recruitmentintegrinCXCR2 |
| spellingShingle | Alex eZarbock Anika eStadtmann CXCR2: From Bench to Bedside Frontiers in Immunology signaling chemokine receptor Leukocyte recruitment integrin CXCR2 |
| title | CXCR2: From Bench to Bedside |
| title_full | CXCR2: From Bench to Bedside |
| title_fullStr | CXCR2: From Bench to Bedside |
| title_full_unstemmed | CXCR2: From Bench to Bedside |
| title_short | CXCR2: From Bench to Bedside |
| title_sort | cxcr2 from bench to bedside |
| topic | signaling chemokine receptor Leukocyte recruitment integrin CXCR2 |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00263/full |
| work_keys_str_mv | AT alexezarbock cxcr2frombenchtobedside AT anikaestadtmann cxcr2frombenchtobedside |