Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designs
Background Growing evidence suggests that environmental air pollution adversely affects kidney health. To date, the association between carbon monoxide (CO) and mortality in patients with end-stage renal disease (ESRD) has not been examined. Methods Among 134,478 dialysis patients in the Korean ESRD...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2022-09-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-21-228.pdf |
| _version_ | 1811179857015472128 |
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| author | Hyuk Huh Ejin Kim Una Amelia Yoon Mun Jeong Choi Hyewon Lee Soie Kwon Clara Tammy Kim Dong Ki Kim Yon Su Kim Chun Soo Lim Jung Pyo Lee Ho Kim Yong Chul Kim |
| author_facet | Hyuk Huh Ejin Kim Una Amelia Yoon Mun Jeong Choi Hyewon Lee Soie Kwon Clara Tammy Kim Dong Ki Kim Yon Su Kim Chun Soo Lim Jung Pyo Lee Ho Kim Yong Chul Kim |
| author_sort | Hyuk Huh |
| collection | DOAJ |
| description | Background Growing evidence suggests that environmental air pollution adversely affects kidney health. To date, the association between carbon monoxide (CO) and mortality in patients with end-stage renal disease (ESRD) has not been examined. Methods Among 134,478 dialysis patients in the Korean ESRD cohort between 2001 and 2014, 8,130 deceased hemodialysis patients were enrolled, and data were analyzed using bidirectional, unidirectional, and time-stratified case-crossover design. We examined the association between short-term CO concentration and mortality in patients with ESRD. We used a two-pollutant model, adjusted for temperature as a climate factor and for nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and particulate matter less than 10 μm in diameter as air pollution variables other than CO. Results Characteristics of the study population included age (66.2 ± 12.1 years), sex (male, 59.1%; female, 40.9%), and comorbidities (diabetes, 55.6%; hypertension, 14.4%). Concentration of CO was significantly associated with all-cause mortality in the three case-crossover designs using the two-pollutant model adjusted for SO2. Patients with diabetes or age older than 75 years had a higher risk of mortality than patients without diabetes or those younger than 75 years. Conclusion Findings presented here suggest that higher CO concentration is correlated with increased all-cause mortality in hemodialysis patients, especially in older high-risk patients. |
| first_indexed | 2024-04-11T06:40:37Z |
| format | Article |
| id | doaj.art-8c9e8473b6814a89bb2d1d8ce8ec15a1 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-04-11T06:40:37Z |
| publishDate | 2022-09-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-8c9e8473b6814a89bb2d1d8ce8ec15a12022-12-22T04:39:33ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402022-09-0141560161010.23876/j.krcp.21.2286145Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designsHyuk Huh0Ejin Kim1Una Amelia Yoon2Mun Jeong Choi3Hyewon Lee4Soie Kwon5Clara Tammy Kim6Dong Ki Kim7Yon Su Kim8Chun Soo Lim9Jung Pyo Lee10Ho Kim11Yong Chul Kim12 Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Institute of Health and Environment, Graduate School of Public Health Seoul National University, Seoul, Republic of Korea Department of Biostatistics and Epidemiology, Graduate School of Public Health, Seoul National University Department of Biostatistics and Epidemiology, Graduate School of Public Health, Seoul National University Department of Health Administration and Management, College of Medical Sciences, Soonchunhyang University, Asan, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Institute of Life and Death Studies, Hallym University, Chuncheon, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea Kidney Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea Institute of Health and Environment, Graduate School of Public Health Seoul National University, Seoul, Republic of Korea Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaBackground Growing evidence suggests that environmental air pollution adversely affects kidney health. To date, the association between carbon monoxide (CO) and mortality in patients with end-stage renal disease (ESRD) has not been examined. Methods Among 134,478 dialysis patients in the Korean ESRD cohort between 2001 and 2014, 8,130 deceased hemodialysis patients were enrolled, and data were analyzed using bidirectional, unidirectional, and time-stratified case-crossover design. We examined the association between short-term CO concentration and mortality in patients with ESRD. We used a two-pollutant model, adjusted for temperature as a climate factor and for nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and particulate matter less than 10 μm in diameter as air pollution variables other than CO. Results Characteristics of the study population included age (66.2 ± 12.1 years), sex (male, 59.1%; female, 40.9%), and comorbidities (diabetes, 55.6%; hypertension, 14.4%). Concentration of CO was significantly associated with all-cause mortality in the three case-crossover designs using the two-pollutant model adjusted for SO2. Patients with diabetes or age older than 75 years had a higher risk of mortality than patients without diabetes or those younger than 75 years. Conclusion Findings presented here suggest that higher CO concentration is correlated with increased all-cause mortality in hemodialysis patients, especially in older high-risk patients.http://www.krcp-ksn.org/upload/pdf/j-krcp-21-228.pdfcarbon monoxideelderlyhemodialysismortality |
| spellingShingle | Hyuk Huh Ejin Kim Una Amelia Yoon Mun Jeong Choi Hyewon Lee Soie Kwon Clara Tammy Kim Dong Ki Kim Yon Su Kim Chun Soo Lim Jung Pyo Lee Ho Kim Yong Chul Kim Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designs Kidney Research and Clinical Practice carbon monoxide elderly hemodialysis mortality |
| title | Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designs |
| title_full | Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designs |
| title_fullStr | Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designs |
| title_full_unstemmed | Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designs |
| title_short | Ambient carbon monoxide correlates with mortality risk of hemodialysis patients: comparing results of control selection in the case-crossover designs |
| title_sort | ambient carbon monoxide correlates with mortality risk of hemodialysis patients comparing results of control selection in the case crossover designs |
| topic | carbon monoxide elderly hemodialysis mortality |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-21-228.pdf |
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