The Association Between Cancer and Dementia: A National Cohort Study in Sweden
Background: Previous studies have found that the incidence of dementia is lower in patients with cancer. However, the impact of survival bias, as well as the confounding by medical treatment, have not been fully addressed. We aimed to explore the subsequent risk of dementia in different follow-up in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00073/full |
| _version_ | 1818538064054583296 |
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| author | Ming Sun Ming Sun Youxin Wang Jan Sundquist Jan Sundquist Jan Sundquist Kristina Sundquist Kristina Sundquist Kristina Sundquist Jianguang Ji |
| author_facet | Ming Sun Ming Sun Youxin Wang Jan Sundquist Jan Sundquist Jan Sundquist Kristina Sundquist Kristina Sundquist Kristina Sundquist Jianguang Ji |
| author_sort | Ming Sun |
| collection | DOAJ |
| description | Background: Previous studies have found that the incidence of dementia is lower in patients with cancer. However, the impact of survival bias, as well as the confounding by medical treatment, have not been fully addressed. We aimed to explore the subsequent risk of dementia in different follow-up intervals among patients with cancer, as well as the risk before the diagnosis of cancer.Methods: By using the Swedish Cancer Register and the Swedish Hospital Discharge Register, we systematically examined the risk of dementia among patients diagnosed with 35 different types of cancer. Standardized incidence ratios (SIRs) were used to calculate the relative risk.Results: The subsequent risk of dementia in patients with cancer decreased by 21% compared to matched cancer-free controls (SIR = 0.79, 95% CI 0.78–0.80). For specific cancer sites, 21 of them had a significantly lower risk of subsequent dementia. The decreased risk of dementia was also significant before the diagnosis of cancer. However, the risk was higher among patients with cancer who survived for more than 10 years' post-diagnosis (SIR = 1.37, 95% CI 1.32–1.41).Conclusions: In this population-based study, we found that the risk of dementia was lower among patients with cancer, and the risk was also lower before the diagnosis of cancer. This suggests that lower dementia risk is not simply due to bias. However, the underlying mechanisms need to be explored further. |
| first_indexed | 2024-12-11T18:58:46Z |
| format | Article |
| id | doaj.art-8ca5a6c408d943fd93ab1360b63df80c |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-11T18:58:46Z |
| publishDate | 2020-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8ca5a6c408d943fd93ab1360b63df80c2022-12-22T00:54:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-02-011010.3389/fonc.2020.00073505616The Association Between Cancer and Dementia: A National Cohort Study in SwedenMing Sun0Ming Sun1Youxin Wang2Jan Sundquist3Jan Sundquist4Jan Sundquist5Kristina Sundquist6Kristina Sundquist7Kristina Sundquist8Jianguang Ji9Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaCenter for Primary Health Care Research, Lund University/Region Skåne, Lund, SwedenBeijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, ChinaCenter for Primary Health Care Research, Lund University/Region Skåne, Lund, SwedenDepartment of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Functional Pathology, Center for Community-based Healthcare Research and Education (CoHRE), School of Medicine, Shimane University, Matsue, JapanCenter for Primary Health Care Research, Lund University/Region Skåne, Lund, SwedenDepartment of Family Medicine and Community Health, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Functional Pathology, Center for Community-based Healthcare Research and Education (CoHRE), School of Medicine, Shimane University, Matsue, JapanCenter for Primary Health Care Research, Lund University/Region Skåne, Lund, SwedenBackground: Previous studies have found that the incidence of dementia is lower in patients with cancer. However, the impact of survival bias, as well as the confounding by medical treatment, have not been fully addressed. We aimed to explore the subsequent risk of dementia in different follow-up intervals among patients with cancer, as well as the risk before the diagnosis of cancer.Methods: By using the Swedish Cancer Register and the Swedish Hospital Discharge Register, we systematically examined the risk of dementia among patients diagnosed with 35 different types of cancer. Standardized incidence ratios (SIRs) were used to calculate the relative risk.Results: The subsequent risk of dementia in patients with cancer decreased by 21% compared to matched cancer-free controls (SIR = 0.79, 95% CI 0.78–0.80). For specific cancer sites, 21 of them had a significantly lower risk of subsequent dementia. The decreased risk of dementia was also significant before the diagnosis of cancer. However, the risk was higher among patients with cancer who survived for more than 10 years' post-diagnosis (SIR = 1.37, 95% CI 1.32–1.41).Conclusions: In this population-based study, we found that the risk of dementia was lower among patients with cancer, and the risk was also lower before the diagnosis of cancer. This suggests that lower dementia risk is not simply due to bias. However, the underlying mechanisms need to be explored further.https://www.frontiersin.org/article/10.3389/fonc.2020.00073/fullcancerdementiainverse associationincidencenationwide |
| spellingShingle | Ming Sun Ming Sun Youxin Wang Jan Sundquist Jan Sundquist Jan Sundquist Kristina Sundquist Kristina Sundquist Kristina Sundquist Jianguang Ji The Association Between Cancer and Dementia: A National Cohort Study in Sweden Frontiers in Oncology cancer dementia inverse association incidence nationwide |
| title | The Association Between Cancer and Dementia: A National Cohort Study in Sweden |
| title_full | The Association Between Cancer and Dementia: A National Cohort Study in Sweden |
| title_fullStr | The Association Between Cancer and Dementia: A National Cohort Study in Sweden |
| title_full_unstemmed | The Association Between Cancer and Dementia: A National Cohort Study in Sweden |
| title_short | The Association Between Cancer and Dementia: A National Cohort Study in Sweden |
| title_sort | association between cancer and dementia a national cohort study in sweden |
| topic | cancer dementia inverse association incidence nationwide |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.00073/full |
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