Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury
Myocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases, and the mechanism of its occurrence involves multiple complex metabolic pathways and signaling pathways. Among these pathways, glucose metabolism and lipid metabolism play important roles in regulating myocardia...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223006170 |
| _version_ | 1797822126618574848 |
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| author | Hao Tian Xiaoshuai Zhao Yuxi Zhang Zhongyuan Xia |
| author_facet | Hao Tian Xiaoshuai Zhao Yuxi Zhang Zhongyuan Xia |
| author_sort | Hao Tian |
| collection | DOAJ |
| description | Myocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases, and the mechanism of its occurrence involves multiple complex metabolic pathways and signaling pathways. Among these pathways, glucose metabolism and lipid metabolism play important roles in regulating myocardial energy metabolism. Therefore, this article focuses on the roles of glucose metabolism and lipid metabolism in myocardial ischemia-reperfusion injury, including glycolysis, glucose uptake and transport, glycogen metabolism and the pentose phosphate pathway; and triglyceride metabolism, fatty acid uptake and transport, phospholipid metabolism, lipoprotein metabolism, and cholesterol metabolism. Finally, due to the different alterations and development of glucose metabolism and lipid metabolism in myocardial ischemia-reperfusion, there are also complex interregulatory relationships between them. In the future, modulating the equilibrium between glucose metabolism and lipid metabolism in cardiomyocytes and ameliorating aberrations in myocardial energy metabolism represent highly promising novel strategies for addressing myocardial ischemia-reperfusion injury. Therefore, a comprehensive exploration of glycolipid metabolism can offer novel theoretical and clinical insights into the prevention and treatment of myocardial ischemia-reperfusion injury. |
| first_indexed | 2024-03-13T10:03:18Z |
| format | Article |
| id | doaj.art-8ca6800a02804857a6ad7c6b5f32d601 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T10:03:18Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-8ca6800a02804857a6ad7c6b5f32d6012023-05-23T04:21:13ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-07-01163114827Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injuryHao Tian0Xiaoshuai Zhao1Yuxi Zhang2Zhongyuan Xia3Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaCorresponding author.; Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, ChinaMyocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases, and the mechanism of its occurrence involves multiple complex metabolic pathways and signaling pathways. Among these pathways, glucose metabolism and lipid metabolism play important roles in regulating myocardial energy metabolism. Therefore, this article focuses on the roles of glucose metabolism and lipid metabolism in myocardial ischemia-reperfusion injury, including glycolysis, glucose uptake and transport, glycogen metabolism and the pentose phosphate pathway; and triglyceride metabolism, fatty acid uptake and transport, phospholipid metabolism, lipoprotein metabolism, and cholesterol metabolism. Finally, due to the different alterations and development of glucose metabolism and lipid metabolism in myocardial ischemia-reperfusion, there are also complex interregulatory relationships between them. In the future, modulating the equilibrium between glucose metabolism and lipid metabolism in cardiomyocytes and ameliorating aberrations in myocardial energy metabolism represent highly promising novel strategies for addressing myocardial ischemia-reperfusion injury. Therefore, a comprehensive exploration of glycolipid metabolism can offer novel theoretical and clinical insights into the prevention and treatment of myocardial ischemia-reperfusion injury.http://www.sciencedirect.com/science/article/pii/S0753332223006170Glucose metabolismLipid metabolismMyocardial ischemia-reperfusionIschemic myocardial diseaseMetabolism |
| spellingShingle | Hao Tian Xiaoshuai Zhao Yuxi Zhang Zhongyuan Xia Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury Biomedicine & Pharmacotherapy Glucose metabolism Lipid metabolism Myocardial ischemia-reperfusion Ischemic myocardial disease Metabolism |
| title | Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury |
| title_full | Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury |
| title_fullStr | Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury |
| title_full_unstemmed | Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury |
| title_short | Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury |
| title_sort | abnormalities of glucose and lipid metabolism in myocardial ischemia reperfusion injury |
| topic | Glucose metabolism Lipid metabolism Myocardial ischemia-reperfusion Ischemic myocardial disease Metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223006170 |
| work_keys_str_mv | AT haotian abnormalitiesofglucoseandlipidmetabolisminmyocardialischemiareperfusioninjury AT xiaoshuaizhao abnormalitiesofglucoseandlipidmetabolisminmyocardialischemiareperfusioninjury AT yuxizhang abnormalitiesofglucoseandlipidmetabolisminmyocardialischemiareperfusioninjury AT zhongyuanxia abnormalitiesofglucoseandlipidmetabolisminmyocardialischemiareperfusioninjury |