Effectiveness of Percutaneous Ethanol Injection Therapy Compared to Parathyroidectomy in the Management of Secondary and Tertiary Hyperparathyroidism
Background: Secondary hyperparathyroidism (SHPT) and tertiary hyperparathyroidism (THPT) are a common complication of chronic renal failure. Percutaneous ethanol injection therapy (PEIT) has been used as alternative to surgery, but its effectiveness is inconsistent. Objectives: The objective of the...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2019-01-01
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| Series: | The Arab Journal of Interventional Radiology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.4103/AJIR.AJIR_37_18 |
| _version_ | 1819080128471236608 |
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| author | Inmutto Nakarin Srisuwan Tanop Kattipatanapong Thanate Pochan Prach |
| author_facet | Inmutto Nakarin Srisuwan Tanop Kattipatanapong Thanate Pochan Prach |
| author_sort | Inmutto Nakarin |
| collection | DOAJ |
| description | Background: Secondary hyperparathyroidism (SHPT) and tertiary hyperparathyroidism (THPT) are a common complication of chronic renal failure. Percutaneous ethanol injection therapy (PEIT) has been used as alternative to surgery, but its effectiveness is inconsistent. Objectives: The objective of the study is to evaluate the effectiveness of PEIT in the management of patients with SHPT and THPT. Materials and Methods: Ninety-one patients with chronic renal failure and SHPT or THPT were treated with PEIT (n = 55) and surgery (n = 36) between January 2006 and July 2015. The medical records, imaging studies, and ablation techniques were reviewed to assess the efficacy of each treatment modality and complications. Results: Parathyroid hormone (PTH) level after treatment <160 pg/mL was used to indicate success of treatment. PEIT showed lower effectiveness compared to surgery (1.8% vs. 61.1%). There was no complication in PEIT group. Symptomatic hypocalcemia was found 11.1% in surgery group. Conclusion: PEIT in treatment of secondary and THPT was much less effective than surgery due to large nodule sizes, high levels of PTH, and multiple parathyroid nodules. |
| first_indexed | 2024-12-21T19:39:57Z |
| format | Article |
| id | doaj.art-8ca734a4336144249382b49a58b3ef8c |
| institution | Directory Open Access Journal |
| issn | 2542-7075 2542-7083 |
| language | English |
| last_indexed | 2024-12-21T19:39:57Z |
| publishDate | 2019-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | The Arab Journal of Interventional Radiology |
| spelling | doaj.art-8ca734a4336144249382b49a58b3ef8c2022-12-21T18:52:30ZengThieme Medical and Scientific Publishers Pvt. Ltd.The Arab Journal of Interventional Radiology2542-70752542-70832019-01-01301151810.4103/AJIR.AJIR_37_18Effectiveness of Percutaneous Ethanol Injection Therapy Compared to Parathyroidectomy in the Management of Secondary and Tertiary HyperparathyroidismInmutto Nakarin0Srisuwan Tanop1Kattipatanapong Thanate2Pochan Prach3Department of Radiology, Chiang Mai University, Chiang Mai, ThailandDepartment of Radiology, Chiang Mai University, Chiang Mai, ThailandDepartment of Radiology, Chiang Mai University, Chiang Mai, ThailandDepartment of Radiology, Chiang Mai University, Chiang Mai, ThailandBackground: Secondary hyperparathyroidism (SHPT) and tertiary hyperparathyroidism (THPT) are a common complication of chronic renal failure. Percutaneous ethanol injection therapy (PEIT) has been used as alternative to surgery, but its effectiveness is inconsistent. Objectives: The objective of the study is to evaluate the effectiveness of PEIT in the management of patients with SHPT and THPT. Materials and Methods: Ninety-one patients with chronic renal failure and SHPT or THPT were treated with PEIT (n = 55) and surgery (n = 36) between January 2006 and July 2015. The medical records, imaging studies, and ablation techniques were reviewed to assess the efficacy of each treatment modality and complications. Results: Parathyroid hormone (PTH) level after treatment <160 pg/mL was used to indicate success of treatment. PEIT showed lower effectiveness compared to surgery (1.8% vs. 61.1%). There was no complication in PEIT group. Symptomatic hypocalcemia was found 11.1% in surgery group. Conclusion: PEIT in treatment of secondary and THPT was much less effective than surgery due to large nodule sizes, high levels of PTH, and multiple parathyroid nodules.http://www.thieme-connect.de/DOI/DOI?10.4103/AJIR.AJIR_37_18chronic renal failurepercutaneous ethanol injection therapysecondary hyperparathyroidismtertiary hyperparathyroidism |
| spellingShingle | Inmutto Nakarin Srisuwan Tanop Kattipatanapong Thanate Pochan Prach Effectiveness of Percutaneous Ethanol Injection Therapy Compared to Parathyroidectomy in the Management of Secondary and Tertiary Hyperparathyroidism The Arab Journal of Interventional Radiology chronic renal failure percutaneous ethanol injection therapy secondary hyperparathyroidism tertiary hyperparathyroidism |
| title | Effectiveness of Percutaneous Ethanol Injection Therapy Compared to Parathyroidectomy in the Management of Secondary and Tertiary Hyperparathyroidism |
| title_full | Effectiveness of Percutaneous Ethanol Injection Therapy Compared to Parathyroidectomy in the Management of Secondary and Tertiary Hyperparathyroidism |
| title_fullStr | Effectiveness of Percutaneous Ethanol Injection Therapy Compared to Parathyroidectomy in the Management of Secondary and Tertiary Hyperparathyroidism |
| title_full_unstemmed | Effectiveness of Percutaneous Ethanol Injection Therapy Compared to Parathyroidectomy in the Management of Secondary and Tertiary Hyperparathyroidism |
| title_short | Effectiveness of Percutaneous Ethanol Injection Therapy Compared to Parathyroidectomy in the Management of Secondary and Tertiary Hyperparathyroidism |
| title_sort | effectiveness of percutaneous ethanol injection therapy compared to parathyroidectomy in the management of secondary and tertiary hyperparathyroidism |
| topic | chronic renal failure percutaneous ethanol injection therapy secondary hyperparathyroidism tertiary hyperparathyroidism |
| url | http://www.thieme-connect.de/DOI/DOI?10.4103/AJIR.AJIR_37_18 |
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