Metastasis of cervical cancer indicated by elevation of serum CA125 produced by mediastinal lymph nodes: a case report
Abstract Background In patient assessment for recurrence of neoplasia, a biomarker that shows an elevated serum value before the first treatment is a candidate for follow-up examination. The biomarker squamous cell carcinoma antigen is usually utilized for follow-up of squamous cell cancer of the ce...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-024-04417-2 |
| _version_ | 1797274453119336448 |
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| author | Ken-ichi Honda Masato Miyama Yuko Nishii Reiko Tasaka Yusuke Nakano Naohiko Umesaki Takeshi Fukuda Tomoyuki Ichimura Tomoyo Yasui Toshiyuki Sumi |
| author_facet | Ken-ichi Honda Masato Miyama Yuko Nishii Reiko Tasaka Yusuke Nakano Naohiko Umesaki Takeshi Fukuda Tomoyuki Ichimura Tomoyo Yasui Toshiyuki Sumi |
| author_sort | Ken-ichi Honda |
| collection | DOAJ |
| description | Abstract Background In patient assessment for recurrence of neoplasia, a biomarker that shows an elevated serum value before the first treatment is a candidate for follow-up examination. The biomarker squamous cell carcinoma antigen is usually utilized for follow-up of squamous cell cancer of the cervix. Case presentation We herein report a 30-year-old Japanese woman of postoperative metastasis of cervical squamous cell cancer to the mediastinal and supraclavicular lymph nodes as indicated by an elevated serum cancer antigen 125 concentration and not by the squamous cell carcinoma antigen value. After chemoradiotherapy and chemotherapy, the serum cancer antigen 125 concentration decreased to a normal value. Squamous cell carcinoma antigen was found to be distributed in both the squamous cell cancer tissue of the cervix and the supraclavicular lymph node metastatic tissue. By contrast, cancer antigen 125 was distributed in the supraclavicular lymph node metastatic tissue but not in the original squamous cell cancer tissue of the cervix. Conclusion In this case, metastasis of cervical cancer to the mediastinal and supraclavicular lymph nodes was shown by the biomarker cancer antigen 125, which was not present in the original neoplasia. |
| first_indexed | 2024-03-07T14:59:34Z |
| format | Article |
| id | doaj.art-8ca9c1c97186434ea3c26e94316cd4d1 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-03-07T14:59:34Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-8ca9c1c97186434ea3c26e94316cd4d12024-03-05T19:14:53ZengBMCJournal of Medical Case Reports1752-19472024-02-011811510.1186/s13256-024-04417-2Metastasis of cervical cancer indicated by elevation of serum CA125 produced by mediastinal lymph nodes: a case reportKen-ichi Honda0Masato Miyama1Yuko Nishii2Reiko Tasaka3Yusuke Nakano4Naohiko Umesaki5Takeshi Fukuda6Tomoyuki Ichimura7Tomoyo Yasui8Toshiyuki Sumi9Department of Obstetrics and Gynecology, PL HospitalDepartment of Gynecology, Izumi City General HospitalMedCity21Department of Obstetrics and Gynecology, Graduate School of Medicine, Osaka Metropolitan UniversityDepartment of Oncology, Izumi City General HospitalDepartment of Gynecology, Izumi City General HospitalDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka Metropolitan UniversityDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka Metropolitan UniversityDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka Metropolitan UniversityDepartment of Obstetrics and Gynecology, Graduate School of Medicine, Osaka Metropolitan UniversityAbstract Background In patient assessment for recurrence of neoplasia, a biomarker that shows an elevated serum value before the first treatment is a candidate for follow-up examination. The biomarker squamous cell carcinoma antigen is usually utilized for follow-up of squamous cell cancer of the cervix. Case presentation We herein report a 30-year-old Japanese woman of postoperative metastasis of cervical squamous cell cancer to the mediastinal and supraclavicular lymph nodes as indicated by an elevated serum cancer antigen 125 concentration and not by the squamous cell carcinoma antigen value. After chemoradiotherapy and chemotherapy, the serum cancer antigen 125 concentration decreased to a normal value. Squamous cell carcinoma antigen was found to be distributed in both the squamous cell cancer tissue of the cervix and the supraclavicular lymph node metastatic tissue. By contrast, cancer antigen 125 was distributed in the supraclavicular lymph node metastatic tissue but not in the original squamous cell cancer tissue of the cervix. Conclusion In this case, metastasis of cervical cancer to the mediastinal and supraclavicular lymph nodes was shown by the biomarker cancer antigen 125, which was not present in the original neoplasia.https://doi.org/10.1186/s13256-024-04417-2Cervical cancerBiomarkerSCCACA125Lymph nodes |
| spellingShingle | Ken-ichi Honda Masato Miyama Yuko Nishii Reiko Tasaka Yusuke Nakano Naohiko Umesaki Takeshi Fukuda Tomoyuki Ichimura Tomoyo Yasui Toshiyuki Sumi Metastasis of cervical cancer indicated by elevation of serum CA125 produced by mediastinal lymph nodes: a case report Journal of Medical Case Reports Cervical cancer Biomarker SCCA CA125 Lymph nodes |
| title | Metastasis of cervical cancer indicated by elevation of serum CA125 produced by mediastinal lymph nodes: a case report |
| title_full | Metastasis of cervical cancer indicated by elevation of serum CA125 produced by mediastinal lymph nodes: a case report |
| title_fullStr | Metastasis of cervical cancer indicated by elevation of serum CA125 produced by mediastinal lymph nodes: a case report |
| title_full_unstemmed | Metastasis of cervical cancer indicated by elevation of serum CA125 produced by mediastinal lymph nodes: a case report |
| title_short | Metastasis of cervical cancer indicated by elevation of serum CA125 produced by mediastinal lymph nodes: a case report |
| title_sort | metastasis of cervical cancer indicated by elevation of serum ca125 produced by mediastinal lymph nodes a case report |
| topic | Cervical cancer Biomarker SCCA CA125 Lymph nodes |
| url | https://doi.org/10.1186/s13256-024-04417-2 |
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