Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling

Cotinine Enhances Fear Extinction and Astrocyte Survival by Mechanisms Involving the Nicotinic Acetylcholine Receptors Signaling

Fear memory extinction (FE) is an important therapeutic goal for Posttraumatic stress disorder (PTSD). Cotinine facilitates FE in rodents, in part due to its inhibitory effect on the amygdala by the glutamatergic projections from the medial prefrontal cortex (mPFC). The cellular and behavioral effec...

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Bibliographic Details
Main Authors: Patricia Oliveros-Matus, Nelson Perez-Urrutia, Nathalie Alvarez-Ricartes, Florencia Echeverria, George E. Barreto, James Elliott, Alexandre Iarkov, Valentina Echeverria
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
fear conditioning
bone morphogenetic proteins
prefrontal cortex
cholinergic receptors
MLA
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00303/full

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