Tumor targeted cancer membrane-camouflaged ultra-small Fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in glioma
Glioma is recognized as the most common and aggressive primary brain tumor in adults. Owing to the occurrence of drug resistance and the failure of drug to penetrate the blood-brain barrier (BBB), there is no effective strategy for the treatment of glioma. The main objective of this study was to dev...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423002405 |
| _version_ | 1827815456634830848 |
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| author | Jingchen Wang Jian Yang Kang Liu Jiayu Yuan Yijie Shi Hongdan Li Liang Zhao |
| author_facet | Jingchen Wang Jian Yang Kang Liu Jiayu Yuan Yijie Shi Hongdan Li Liang Zhao |
| author_sort | Jingchen Wang |
| collection | DOAJ |
| description | Glioma is recognized as the most common and aggressive primary brain tumor in adults. Owing to the occurrence of drug resistance and the failure of drug to penetrate the blood-brain barrier (BBB), there is no effective strategy for the treatment of glioma. The main objective of this study was to develop a biomimetic glioma C6 cell membrane (C6M) derived nanovesicles (DOX-FN/C6M-NVs) loaded with doxorubicin (DOX) and ultra-small Fe nanoparticles (FN) for accomplishing the effective brain tumor-targeted delivery of DOX and improving anti-cancer efficacy via inducing collaborative apoptosis and ferroptosis. The findings revealed that employing C6M-NVs as a carrier significantly improved the therapeutic efficacy by enabling evasion of immune surveillance, facilitating targeted drug delivery to tumor sites, and minimizing cardiotoxicity and adverse effects associated with DOX. DOX-FN/C6M-NVs exhibited more potent anti-tumor effects as compared with free DOX by promoting DOX-mediated apoptosis and accelerating ferroptosis via the mediation of FN. This study suggested that DOX-FN/C6M-NVs as the potential inducer of ferroptosis and apoptosis conferred effective tumor suppression in the treatment of glioma. |
| first_indexed | 2024-03-12T00:00:14Z |
| format | Article |
| id | doaj.art-8ca9d2a1a4ed4bcb8da82b981a8df91d |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-12T00:00:14Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-8ca9d2a1a4ed4bcb8da82b981a8df91d2023-09-18T04:30:22ZengElsevierMaterials Today Bio2590-00642023-10-0122100780Tumor targeted cancer membrane-camouflaged ultra-small Fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in gliomaJingchen Wang0Jian Yang1Kang Liu2Jiayu Yuan3Yijie Shi4Hongdan Li5Liang Zhao6School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, PR ChinaLife Science Institution, Jinzhou Medical University, Jinzhou, 121000, PR ChinaSchool of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, PR ChinaSchool of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, PR ChinaSchool of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, PR ChinaLife Science Institution, Jinzhou Medical University, Jinzhou, 121000, PR China; Corresponding author.School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, PR China; Corresponding author.Glioma is recognized as the most common and aggressive primary brain tumor in adults. Owing to the occurrence of drug resistance and the failure of drug to penetrate the blood-brain barrier (BBB), there is no effective strategy for the treatment of glioma. The main objective of this study was to develop a biomimetic glioma C6 cell membrane (C6M) derived nanovesicles (DOX-FN/C6M-NVs) loaded with doxorubicin (DOX) and ultra-small Fe nanoparticles (FN) for accomplishing the effective brain tumor-targeted delivery of DOX and improving anti-cancer efficacy via inducing collaborative apoptosis and ferroptosis. The findings revealed that employing C6M-NVs as a carrier significantly improved the therapeutic efficacy by enabling evasion of immune surveillance, facilitating targeted drug delivery to tumor sites, and minimizing cardiotoxicity and adverse effects associated with DOX. DOX-FN/C6M-NVs exhibited more potent anti-tumor effects as compared with free DOX by promoting DOX-mediated apoptosis and accelerating ferroptosis via the mediation of FN. This study suggested that DOX-FN/C6M-NVs as the potential inducer of ferroptosis and apoptosis conferred effective tumor suppression in the treatment of glioma.http://www.sciencedirect.com/science/article/pii/S2590006423002405GliomaNanovesiclesDoxorubicinNanoparticlesFerroptosis |
| spellingShingle | Jingchen Wang Jian Yang Kang Liu Jiayu Yuan Yijie Shi Hongdan Li Liang Zhao Tumor targeted cancer membrane-camouflaged ultra-small Fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in glioma Materials Today Bio Glioma Nanovesicles Doxorubicin Nanoparticles Ferroptosis |
| title | Tumor targeted cancer membrane-camouflaged ultra-small Fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in glioma |
| title_full | Tumor targeted cancer membrane-camouflaged ultra-small Fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in glioma |
| title_fullStr | Tumor targeted cancer membrane-camouflaged ultra-small Fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in glioma |
| title_full_unstemmed | Tumor targeted cancer membrane-camouflaged ultra-small Fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in glioma |
| title_short | Tumor targeted cancer membrane-camouflaged ultra-small Fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in glioma |
| title_sort | tumor targeted cancer membrane camouflaged ultra small fe nanoparticles for enhanced collaborative apoptosis and ferroptosis in glioma |
| topic | Glioma Nanovesicles Doxorubicin Nanoparticles Ferroptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423002405 |
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