Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes
Flavonoids are ubiquitous groups of polyphenolic compounds present in most natural products and plants. These substances have been shown to have promising chemopreventive and chemotherapeutic properties with multiple target interactions and multiple pathway regulations against various human cancers....
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/19/5781 |
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| author | Cristiane Okuda Torello Marisa Claudia Alvarez Sara T. Olalla Saad |
| author_facet | Cristiane Okuda Torello Marisa Claudia Alvarez Sara T. Olalla Saad |
| author_sort | Cristiane Okuda Torello |
| collection | DOAJ |
| description | Flavonoids are ubiquitous groups of polyphenolic compounds present in most natural products and plants. These substances have been shown to have promising chemopreventive and chemotherapeutic properties with multiple target interactions and multiple pathway regulations against various human cancers. Polyphenolic flavonoid compounds can block the initiation or reverse the promotion stage of multistep carcinogenesis. Quercetin is one of the most abundant flavonoids found in fruits and vegetables and has been shown to have multiple properties capable of reducing cell growth in cancer cells. Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) therapy remains a challenge for hematologists worldwide, and the outcomes for patients with both disorders continue to be poor. This scenario indicates the increasing demand for innovative drugs and rational combinative therapies. Herein, we discuss the multitarget effects of the flavonoid quercetin, a naturally occurring flavonol, on AML and MDS. |
| first_indexed | 2024-03-10T06:55:07Z |
| format | Article |
| id | doaj.art-8caa44ac7db84c2698ce5008c88cd49c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T06:55:07Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8caa44ac7db84c2698ce5008c88cd49c2023-11-22T16:32:33ZengMDPI AGMolecules1420-30492021-09-012619578110.3390/molecules26195781Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic SyndromesCristiane Okuda Torello0Marisa Claudia Alvarez1Sara T. Olalla Saad2Hematology and Transfusion Medicine Center—Hemocentro, University of Campinas, Campinas 13083-878, BrazilHematology and Transfusion Medicine Center—Hemocentro, University of Campinas, Campinas 13083-878, BrazilHematology and Transfusion Medicine Center—Hemocentro, University of Campinas, Campinas 13083-878, BrazilFlavonoids are ubiquitous groups of polyphenolic compounds present in most natural products and plants. These substances have been shown to have promising chemopreventive and chemotherapeutic properties with multiple target interactions and multiple pathway regulations against various human cancers. Polyphenolic flavonoid compounds can block the initiation or reverse the promotion stage of multistep carcinogenesis. Quercetin is one of the most abundant flavonoids found in fruits and vegetables and has been shown to have multiple properties capable of reducing cell growth in cancer cells. Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) therapy remains a challenge for hematologists worldwide, and the outcomes for patients with both disorders continue to be poor. This scenario indicates the increasing demand for innovative drugs and rational combinative therapies. Herein, we discuss the multitarget effects of the flavonoid quercetin, a naturally occurring flavonol, on AML and MDS.https://www.mdpi.com/1420-3049/26/19/5781polyphenolic compoundsquercetinhematological disordersanti-proliferative effectapoptosisautophagy |
| spellingShingle | Cristiane Okuda Torello Marisa Claudia Alvarez Sara T. Olalla Saad Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes Molecules polyphenolic compounds quercetin hematological disorders anti-proliferative effect apoptosis autophagy |
| title | Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes |
| title_full | Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes |
| title_fullStr | Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes |
| title_full_unstemmed | Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes |
| title_short | Polyphenolic Flavonoid Compound Quercetin Effects in the Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes |
| title_sort | polyphenolic flavonoid compound quercetin effects in the treatment of acute myeloid leukemia and myelodysplastic syndromes |
| topic | polyphenolic compounds quercetin hematological disorders anti-proliferative effect apoptosis autophagy |
| url | https://www.mdpi.com/1420-3049/26/19/5781 |
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