The Interplay between Telomeres, Mitochondria, and Chronic Stress Exposure in the Aging Egg
While at the organismal level, biological aging can be estimated by telomere length and DNA methylation signatures, reliable biomarkers that can predict reproductive age are much needed to gauge the quality of an oocyte. Reproductive medicine and fertility centers often merely quantitate the ovarian...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/16/2612 |
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| author | Aksinya Derevyanko Agnieszka Skowronska Mariusz T. Skowronski Paweł Kordowitzki |
| author_facet | Aksinya Derevyanko Agnieszka Skowronska Mariusz T. Skowronski Paweł Kordowitzki |
| author_sort | Aksinya Derevyanko |
| collection | DOAJ |
| description | While at the organismal level, biological aging can be estimated by telomere length and DNA methylation signatures, reliable biomarkers that can predict reproductive age are much needed to gauge the quality of an oocyte. Reproductive medicine and fertility centers often merely quantitate the ovarian reserve to predict the likelihood of fertilization and pregnancy in women of advanced reproductive age. It is highly important to address the level of age-related decline in oocyte quality since it leads to an increased risk of miscarriages and aneuploidy. Conversely, the pathways behind oocyte aging remain, in large part, elusive. Telomere shortening upon chronic stress exposure regulates mitochondria function and biogenesis by various pathways; therefore, establishing a link between these two important players and extrapolating them for the aging of oocytes will be the purpose of our commentary. |
| first_indexed | 2024-03-09T09:59:38Z |
| format | Article |
| id | doaj.art-8cab781c4ba349cf8ea7f69f9ca3a80b |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T09:59:38Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8cab781c4ba349cf8ea7f69f9ca3a80b2023-12-01T23:33:46ZengMDPI AGCells2073-44092022-08-011116261210.3390/cells11162612The Interplay between Telomeres, Mitochondria, and Chronic Stress Exposure in the Aging EggAksinya Derevyanko0Agnieszka Skowronska1Mariusz T. Skowronski2Paweł Kordowitzki3Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USADepartment of Human Physiology and Pathophysiology, Collegium Medicum, University of Warmia and Mazury, 10-719 Olsztyn, PolandDepartment of Basic and Preclinical Sciences, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Torun, PolandDepartment of Basic and Preclinical Sciences, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Torun, PolandWhile at the organismal level, biological aging can be estimated by telomere length and DNA methylation signatures, reliable biomarkers that can predict reproductive age are much needed to gauge the quality of an oocyte. Reproductive medicine and fertility centers often merely quantitate the ovarian reserve to predict the likelihood of fertilization and pregnancy in women of advanced reproductive age. It is highly important to address the level of age-related decline in oocyte quality since it leads to an increased risk of miscarriages and aneuploidy. Conversely, the pathways behind oocyte aging remain, in large part, elusive. Telomere shortening upon chronic stress exposure regulates mitochondria function and biogenesis by various pathways; therefore, establishing a link between these two important players and extrapolating them for the aging of oocytes will be the purpose of our commentary.https://www.mdpi.com/2073-4409/11/16/2612oocyteeggagingtelomeresmitochondriamitochondrial function |
| spellingShingle | Aksinya Derevyanko Agnieszka Skowronska Mariusz T. Skowronski Paweł Kordowitzki The Interplay between Telomeres, Mitochondria, and Chronic Stress Exposure in the Aging Egg Cells oocyte egg aging telomeres mitochondria mitochondrial function |
| title | The Interplay between Telomeres, Mitochondria, and Chronic Stress Exposure in the Aging Egg |
| title_full | The Interplay between Telomeres, Mitochondria, and Chronic Stress Exposure in the Aging Egg |
| title_fullStr | The Interplay between Telomeres, Mitochondria, and Chronic Stress Exposure in the Aging Egg |
| title_full_unstemmed | The Interplay between Telomeres, Mitochondria, and Chronic Stress Exposure in the Aging Egg |
| title_short | The Interplay between Telomeres, Mitochondria, and Chronic Stress Exposure in the Aging Egg |
| title_sort | interplay between telomeres mitochondria and chronic stress exposure in the aging egg |
| topic | oocyte egg aging telomeres mitochondria mitochondrial function |
| url | https://www.mdpi.com/2073-4409/11/16/2612 |
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