Targeting adipokines: A new strategy for the treatment of myocardial fibrosis
Cardiac fibrosis is a pathogenic factor of many cardiovascular diseases (CVD), which seriously affects people's life and health, causing huge economic losses.Therefore, it is very significant to find an effective treatment for myocardial fibrosis. Adipokines are mainly derived from adipose tiss...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-07-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S104366182200202X |
| _version_ | 1797366672753950720 |
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| author | Xiaoying Han Yi Zhang Xinyu Zhang Haixia Ji Wenzhe Wang Ou Qiao Xia Li Juan Wang Changxiao Liu Luqi Huang Wenyuan Gao |
| author_facet | Xiaoying Han Yi Zhang Xinyu Zhang Haixia Ji Wenzhe Wang Ou Qiao Xia Li Juan Wang Changxiao Liu Luqi Huang Wenyuan Gao |
| author_sort | Xiaoying Han |
| collection | DOAJ |
| description | Cardiac fibrosis is a pathogenic factor of many cardiovascular diseases (CVD), which seriously affects people's life and health, causing huge economic losses.Therefore, it is very significant to find an effective treatment for myocardial fibrosis. Adipokines are mainly derived from adipose tissue and have an prominent regulatory effect on glucose and lipid metabolism, inflammation, immune response and cardiovascular function. Adipose tissue is composed of a variety of cell types, including adipocytes, endothelial cells, macrophages and smooth muscle cells. Adipokines mainly include adiponectin, leptin, resistin, visfatin and omentin, which are synthesized and secreted by adipocytes. More and more evidence shows that adipokines can regulate the progress of cardiac fibrosis. This scientific review provides new ideas for targeting adipokines in the treatment of myocardial fibrosis and provides strategies for the development of new, safe, and effective pharmacological antagonists against myocardial fibrosis based on adipokines activity. |
| first_indexed | 2024-03-08T17:07:03Z |
| format | Article |
| id | doaj.art-8cabdbefcf454e66945281dfc3414b5e |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-08T17:07:03Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-8cabdbefcf454e66945281dfc3414b5e2024-01-04T04:37:37ZengElsevierPharmacological Research1096-11862022-07-01181106257Targeting adipokines: A new strategy for the treatment of myocardial fibrosisXiaoying Han0Yi Zhang1Xinyu Zhang2Haixia Ji3Wenzhe Wang4Ou Qiao5Xia Li6Juan Wang7Changxiao Liu8Luqi Huang9Wenyuan Gao10School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR ChinaTianjin Pharmaceutical Research Institute, Tianjin 300072, PR ChinaNational Resource Center for Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, Beijing, PR ChinaSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China; Corresponding author.Cardiac fibrosis is a pathogenic factor of many cardiovascular diseases (CVD), which seriously affects people's life and health, causing huge economic losses.Therefore, it is very significant to find an effective treatment for myocardial fibrosis. Adipokines are mainly derived from adipose tissue and have an prominent regulatory effect on glucose and lipid metabolism, inflammation, immune response and cardiovascular function. Adipose tissue is composed of a variety of cell types, including adipocytes, endothelial cells, macrophages and smooth muscle cells. Adipokines mainly include adiponectin, leptin, resistin, visfatin and omentin, which are synthesized and secreted by adipocytes. More and more evidence shows that adipokines can regulate the progress of cardiac fibrosis. This scientific review provides new ideas for targeting adipokines in the treatment of myocardial fibrosis and provides strategies for the development of new, safe, and effective pharmacological antagonists against myocardial fibrosis based on adipokines activity.http://www.sciencedirect.com/science/article/pii/S104366182200202XAdipokinesCardiac fibrosisCardiovascular dysfunctionAngiotensin systemStrategies |
| spellingShingle | Xiaoying Han Yi Zhang Xinyu Zhang Haixia Ji Wenzhe Wang Ou Qiao Xia Li Juan Wang Changxiao Liu Luqi Huang Wenyuan Gao Targeting adipokines: A new strategy for the treatment of myocardial fibrosis Pharmacological Research Adipokines Cardiac fibrosis Cardiovascular dysfunction Angiotensin system Strategies |
| title | Targeting adipokines: A new strategy for the treatment of myocardial fibrosis |
| title_full | Targeting adipokines: A new strategy for the treatment of myocardial fibrosis |
| title_fullStr | Targeting adipokines: A new strategy for the treatment of myocardial fibrosis |
| title_full_unstemmed | Targeting adipokines: A new strategy for the treatment of myocardial fibrosis |
| title_short | Targeting adipokines: A new strategy for the treatment of myocardial fibrosis |
| title_sort | targeting adipokines a new strategy for the treatment of myocardial fibrosis |
| topic | Adipokines Cardiac fibrosis Cardiovascular dysfunction Angiotensin system Strategies |
| url | http://www.sciencedirect.com/science/article/pii/S104366182200202X |
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