Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study
Abstract Background Contrast enhanced ultrasonography (CEUS) assessment of kidney allografts mainly focuses on graft rejection. However, studies on delayed graft function (DGF) without acute rejection are still lacking. The aim of this study was to build a time-intensity curve (TIC) using CEUS in no...
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-018-1158-0 |
| _version_ | 1818279950198767616 |
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| author | Nordeval Cavalcante Araújo José Hermógenes Rocco Suassuna |
| author_facet | Nordeval Cavalcante Araújo José Hermógenes Rocco Suassuna |
| author_sort | Nordeval Cavalcante Araújo |
| collection | DOAJ |
| description | Abstract Background Contrast enhanced ultrasonography (CEUS) assessment of kidney allografts mainly focuses on graft rejection. However, studies on delayed graft function (DGF) without acute rejection are still lacking. The aim of this study was to build a time-intensity curve (TIC) using CEUS in non-immunological DGF to understand the utility of CEUS in early transplantation. Methods Twenty-eight patients in the short-term postoperative period (<14 days) were divided according to the need for dialysis (early graft function [EGF] and [DGF]) and 37 subjects with longer than 90 days follow-up were divided into creatinine tertiles. Time to peak [TTP] and rising time [RT were compared between groups. Results EGF and DGF were similar, except for creatinine. In comparison to the late group, medullary TTP and RT were shorter in the early group as well as the delay regarding contrast arrival in the medulla (in relation to cortex) and reaching the medullary peak (in relation to artery and cortex). In the late group, patients with renal dysfunction showed shorter temporal difference to reach medullary peak in relation to artery and cortex. Conclusions Although it was not possible to differentiate EGF and DGF using TIC, differences between early and late groups point to blood shunting in renal dysfunction. |
| first_indexed | 2024-12-12T23:41:28Z |
| format | Article |
| id | doaj.art-8caec2884275431fac91c023b1a93f89 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-12T23:41:28Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-8caec2884275431fac91c023b1a93f892022-12-22T00:07:06ZengBMCBMC Nephrology1471-23692018-12-011911810.1186/s12882-018-1158-0Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective studyNordeval Cavalcante Araújo0José Hermógenes Rocco Suassuna1University of the State of Rio de JaneiroUniversity of the State of Rio de JaneiroAbstract Background Contrast enhanced ultrasonography (CEUS) assessment of kidney allografts mainly focuses on graft rejection. However, studies on delayed graft function (DGF) without acute rejection are still lacking. The aim of this study was to build a time-intensity curve (TIC) using CEUS in non-immunological DGF to understand the utility of CEUS in early transplantation. Methods Twenty-eight patients in the short-term postoperative period (<14 days) were divided according to the need for dialysis (early graft function [EGF] and [DGF]) and 37 subjects with longer than 90 days follow-up were divided into creatinine tertiles. Time to peak [TTP] and rising time [RT were compared between groups. Results EGF and DGF were similar, except for creatinine. In comparison to the late group, medullary TTP and RT were shorter in the early group as well as the delay regarding contrast arrival in the medulla (in relation to cortex) and reaching the medullary peak (in relation to artery and cortex). In the late group, patients with renal dysfunction showed shorter temporal difference to reach medullary peak in relation to artery and cortex. Conclusions Although it was not possible to differentiate EGF and DGF using TIC, differences between early and late groups point to blood shunting in renal dysfunction.http://link.springer.com/article/10.1186/s12882-018-1158-0Renal transplantationDelayed graft functionContrast enhanced sonographyrenal blood flow |
| spellingShingle | Nordeval Cavalcante Araújo José Hermógenes Rocco Suassuna Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study BMC Nephrology Renal transplantation Delayed graft function Contrast enhanced sonography renal blood flow |
| title | Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study |
| title_full | Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study |
| title_fullStr | Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study |
| title_full_unstemmed | Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study |
| title_short | Time-intensity curve analysis of contrast-enhanced ultrasound is unable to differentiate renal dysfunction in the early post-transplant period - a prospective study |
| title_sort | time intensity curve analysis of contrast enhanced ultrasound is unable to differentiate renal dysfunction in the early post transplant period a prospective study |
| topic | Renal transplantation Delayed graft function Contrast enhanced sonography renal blood flow |
| url | http://link.springer.com/article/10.1186/s12882-018-1158-0 |
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