Ionizing radiation and volumetric mammographic density
Objectives Mammographic density (MD) refers to the percentage of dense tissue of an entire breast and was proposed to be used as a surrogate marker for breast cancer. High-dose ionizing radiation (IR) has been recognized as a breast cancer risk factor. The aim of our study was to investigate associa...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nofer Institute of Occupational Medicine
2022-08-01
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| Series: | International Journal of Occupational Medicine and Environmental Health |
| Subjects: | |
| Online Access: | http://ijomeh.eu/Ionizing-radiation-and-volumetric-mammographic-density,150294,0,2.html |
| _version_ | 1797980752072146944 |
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| author | Beata Pepłońska Mateusz Mirowski Paweł Kałużny Joanna Domienik-Andrzejewska |
| author_facet | Beata Pepłońska Mateusz Mirowski Paweł Kałużny Joanna Domienik-Andrzejewska |
| author_sort | Beata Pepłońska |
| collection | DOAJ |
| description | Objectives
Mammographic density (MD) refers to the percentage of dense tissue of an entire breast and was proposed to be used as a surrogate
marker for breast cancer. High-dose ionizing radiation (IR) has been recognized as a breast cancer risk factor. The aim of our study was to investigate
association between lifetime low dose ionizing radiation (LDIR) and MD.
Material and Methods
A cross-sectional study included 467 women
aged 40–60 years who underwent screening mammography in Łódź, Poland. The digital mammography examination of the breasts included both
craniocaudal and mediolateral oblique views. The volumetric breast density (VBD) (%) and fibrograndular tissue volume (FG) (cm 3 ) were determined
based on the analysis of mammographic image (“for processing”) using Volpara Imaging Software. The exposure to IR was estimated for each
individual, based on the data from interviews about diagnostic or therapeutic medical procedures performed in the area of the neck, chest, abdomen
and spine, which involved X-rays and γ rays and the data about the doses derived from literature. Linear and logistic regression were fitted with VBD
and FG as the outcomes and organ breast dose, effective dose and number of mammographies as the determinants, adjusted for major confounders.
Results
The analyses showed no association between VBD or FG and the breast organ dose or the effective dose. The only significant finding observed
concerned the association between the number of mammographies and the FG volume with β coefficient: 0.028 (95% CI: 0.012–0.043), and
predicted mean FG volume >13.4 cm3 among the women with >3 mammographies when compared to those with none.
Conclusions
This study
does not, in general, provide support for the positive association between LDIR and MD. The weak association of the FG volume with the number of
mammographies warrants further verification in larger independent studies. Int J Occup Med Environ Health. 2022;35(5):635–49 |
| first_indexed | 2024-04-11T05:59:54Z |
| format | Article |
| id | doaj.art-8cb3424cb4b74a9b8d1cb38c6e423cd5 |
| institution | Directory Open Access Journal |
| issn | 1232-1087 1896-494X |
| language | English |
| last_indexed | 2024-04-11T05:59:54Z |
| publishDate | 2022-08-01 |
| publisher | Nofer Institute of Occupational Medicine |
| record_format | Article |
| series | International Journal of Occupational Medicine and Environmental Health |
| spelling | doaj.art-8cb3424cb4b74a9b8d1cb38c6e423cd52022-12-22T04:41:47ZengNofer Institute of Occupational MedicineInternational Journal of Occupational Medicine and Environmental Health1232-10871896-494X2022-08-0135563564910.13075/ijomeh.1896.01916150294Ionizing radiation and volumetric mammographic densityBeata Pepłońska0Mateusz Mirowski1https://orcid.org/0000-0002-3523-7652Paweł Kałużny2Joanna Domienik-Andrzejewska3Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Environmental Epidemiology)Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Radiation Protection)Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Environmental Epidemiology)Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Radiation Protection)Objectives Mammographic density (MD) refers to the percentage of dense tissue of an entire breast and was proposed to be used as a surrogate marker for breast cancer. High-dose ionizing radiation (IR) has been recognized as a breast cancer risk factor. The aim of our study was to investigate association between lifetime low dose ionizing radiation (LDIR) and MD. Material and Methods A cross-sectional study included 467 women aged 40–60 years who underwent screening mammography in Łódź, Poland. The digital mammography examination of the breasts included both craniocaudal and mediolateral oblique views. The volumetric breast density (VBD) (%) and fibrograndular tissue volume (FG) (cm 3 ) were determined based on the analysis of mammographic image (“for processing”) using Volpara Imaging Software. The exposure to IR was estimated for each individual, based on the data from interviews about diagnostic or therapeutic medical procedures performed in the area of the neck, chest, abdomen and spine, which involved X-rays and γ rays and the data about the doses derived from literature. Linear and logistic regression were fitted with VBD and FG as the outcomes and organ breast dose, effective dose and number of mammographies as the determinants, adjusted for major confounders. Results The analyses showed no association between VBD or FG and the breast organ dose or the effective dose. The only significant finding observed concerned the association between the number of mammographies and the FG volume with β coefficient: 0.028 (95% CI: 0.012–0.043), and predicted mean FG volume >13.4 cm3 among the women with >3 mammographies when compared to those with none. Conclusions This study does not, in general, provide support for the positive association between LDIR and MD. The weak association of the FG volume with the number of mammographies warrants further verification in larger independent studies. Int J Occup Med Environ Health. 2022;35(5):635–49http://ijomeh.eu/Ionizing-radiation-and-volumetric-mammographic-density,150294,0,2.htmlbreast cancerionizing radiationmammographyeffective dosemammographic densityorgan dose |
| spellingShingle | Beata Pepłońska Mateusz Mirowski Paweł Kałużny Joanna Domienik-Andrzejewska Ionizing radiation and volumetric mammographic density International Journal of Occupational Medicine and Environmental Health breast cancer ionizing radiation mammography effective dose mammographic density organ dose |
| title | Ionizing radiation and volumetric mammographic density |
| title_full | Ionizing radiation and volumetric mammographic density |
| title_fullStr | Ionizing radiation and volumetric mammographic density |
| title_full_unstemmed | Ionizing radiation and volumetric mammographic density |
| title_short | Ionizing radiation and volumetric mammographic density |
| title_sort | ionizing radiation and volumetric mammographic density |
| topic | breast cancer ionizing radiation mammography effective dose mammographic density organ dose |
| url | http://ijomeh.eu/Ionizing-radiation-and-volumetric-mammographic-density,150294,0,2.html |
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