AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9

AKAP6 orchestrates the nuclear envelope microtubule-organizing center by linking golgi and nucleus via AKAP9

The switch from centrosomal microtubule-organizing centers (MTOCs) to non-centrosomal MTOCs during differentiation is poorly understood. Here, we identify AKAP6 as key component of the nuclear envelope MTOC. In rat cardiomyocytes, AKAP6 anchors centrosomal proteins to the nuclear envelope through it...

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Bibliographic Details
Main Authors: Silvia Vergarajauregui, Robert Becker, Ulrike Steffen, Maria Sharkova, Tilman Esser, Jana Petzold, Florian Billing, Michael S Kapiloff, George Schett, Ingo Thievessen, Felix B Engel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
non-centrosomal mtoc
AKAP6
cardiomyocyte
nesprin-1α
osteoclast
AKAP9
Online Access:https://elifesciences.org/articles/61669

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