Corneal alteration and pathogenesis in diabetes mellitus
The incidence of diabetes mellitus (DM) and its complications have increased considerably worldwide. Diabetic keratopathy is the major complication of the cornea characterized by delayed corneal wound healing, decreasing corneal epithelial sensitivity, and recurrent corneal ulcers. There is accumula...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2019-12-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2019/12/20191217.pdf |
| _version_ | 1818920016173596672 |
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| author | Han Zhao Yan He Yue-Rong Ren Bai-Hua Chen |
| author_facet | Han Zhao Yan He Yue-Rong Ren Bai-Hua Chen |
| author_sort | Han Zhao |
| collection | DOAJ |
| description | The incidence of diabetes mellitus (DM) and its complications have increased considerably worldwide. Diabetic keratopathy is the major complication of the cornea characterized by delayed corneal wound healing, decreasing corneal epithelial sensitivity, and recurrent corneal ulcers. There is accumulating evidence that diabetic keratopathy is correlated with the hyperglycemic state. Different corneal components may produce different alterations under hyperglycemia. In addition, diabetic nerve alteration may become a novel biomarker of early-stage DM. Abnormalities of the corneal nerve plexus have been associated with diabetic inflammatory states. There is rapidly growing evidence based on investigations of diabetic corneal nerves through in vivo confocal microscopy. Understanding the molecular pathogenesis caused by hyperglycemia may assist in the identification of novel biomarkers, as well as therapeutic targets for early treatment. This review mainly summarizes recent findings on corneal alteration and pathogenesis in DM. |
| first_indexed | 2024-12-20T01:15:03Z |
| format | Article |
| id | doaj.art-8cb6084733084cc7aacb2a5c6d79b96d |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-20T01:15:03Z |
| publishDate | 2019-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-8cb6084733084cc7aacb2a5c6d79b96d2022-12-21T19:58:36ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982019-12-0112121939195010.18240/ijo.2019.12.17Corneal alteration and pathogenesis in diabetes mellitusHan Zhao0Yan He1Yue-Rong Ren2Bai-Hua Chen3Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha 410011, Hunan Province, ChinaDepartment of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha 410011, Hunan Province, ChinaDepartment of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha 410011, Hunan Province, ChinaDepartment of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China; Hunan Clinical Research Center of Ophthalmic Disease, Changsha 410011, Hunan Province, ChinaThe incidence of diabetes mellitus (DM) and its complications have increased considerably worldwide. Diabetic keratopathy is the major complication of the cornea characterized by delayed corneal wound healing, decreasing corneal epithelial sensitivity, and recurrent corneal ulcers. There is accumulating evidence that diabetic keratopathy is correlated with the hyperglycemic state. Different corneal components may produce different alterations under hyperglycemia. In addition, diabetic nerve alteration may become a novel biomarker of early-stage DM. Abnormalities of the corneal nerve plexus have been associated with diabetic inflammatory states. There is rapidly growing evidence based on investigations of diabetic corneal nerves through in vivo confocal microscopy. Understanding the molecular pathogenesis caused by hyperglycemia may assist in the identification of novel biomarkers, as well as therapeutic targets for early treatment. This review mainly summarizes recent findings on corneal alteration and pathogenesis in DM.http://www.ijo.cn/en_publish/2019/12/20191217.pdfdiabetes mellitusdiabetic keratopathydiabetic neuropathyin vivo confocal microscopyadvanced glycation end products |
| spellingShingle | Han Zhao Yan He Yue-Rong Ren Bai-Hua Chen Corneal alteration and pathogenesis in diabetes mellitus International Journal of Ophthalmology diabetes mellitus diabetic keratopathy diabetic neuropathy in vivo confocal microscopy advanced glycation end products |
| title | Corneal alteration and pathogenesis in diabetes mellitus |
| title_full | Corneal alteration and pathogenesis in diabetes mellitus |
| title_fullStr | Corneal alteration and pathogenesis in diabetes mellitus |
| title_full_unstemmed | Corneal alteration and pathogenesis in diabetes mellitus |
| title_short | Corneal alteration and pathogenesis in diabetes mellitus |
| title_sort | corneal alteration and pathogenesis in diabetes mellitus |
| topic | diabetes mellitus diabetic keratopathy diabetic neuropathy in vivo confocal microscopy advanced glycation end products |
| url | http://www.ijo.cn/en_publish/2019/12/20191217.pdf |
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