AMBRA1 attenuates the proliferation of uveal melanoma cells
Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults with high metastasis rates. D-type cyclins (CCNDs) are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer. Recently, the E3 ligase adaptor, au...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-11-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2021-0386 |
| _version_ | 1811203015552532480 |
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| author | Zhao Binbin Yang Yun Cun Biyun Chen Ping |
| author_facet | Zhao Binbin Yang Yun Cun Biyun Chen Ping |
| author_sort | Zhao Binbin |
| collection | DOAJ |
| description | Uveal melanoma (UVM) is the most common primary intraocular malignancy in adults with high metastasis rates. D-type cyclins (CCNDs) are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer. Recently, the E3 ligase adaptor, autophagy and beclin 1 regulator 1 (AMBRA1), was reported to regulate the stability of CCNDs, including CCND1, but its role in UVM has not been demonstrated. AMBRA1 is lowly expressed in UVM cells, and the ablation of AMBRA1 promotes the proliferation of 92.1 and OMM1 cells, whereas ectopically expressing AMBRA1 attenuates the proliferation of UVM cells. Further studies found that AMBRA1 promotes the ubiquitination and degradation of CCND1, and AMBRA1 regulates the proliferation of UVM cells in a CCND1-dependent manner. Thus, this study suggests that AMBRA1 serves as an important tumor suppressor by limiting UVM cell growth. |
| first_indexed | 2024-04-12T02:48:44Z |
| format | Article |
| id | doaj.art-8cb6d8d05b184cc6addf1024a6be9d09 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T02:48:44Z |
| publishDate | 2021-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-8cb6d8d05b184cc6addf1024a6be9d092022-12-22T03:51:05ZengDe GruyterOpen Medicine2391-54632021-11-0117111410.1515/med-2021-0386AMBRA1 attenuates the proliferation of uveal melanoma cellsZhao Binbin0Yang Yun1Cun Biyun2Chen Ping3Department of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, ChinaCenter for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, ChinaDepartment of Clinical Skills Center, Kunming Medical University, Kunming, 650500, Yunnan, ChinaDepartment of Ophthalmology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, ChinaUveal melanoma (UVM) is the most common primary intraocular malignancy in adults with high metastasis rates. D-type cyclins (CCNDs) are central regulators of the cell division cycle and are among the most frequently deregulated therapeutic targets in human cancer. Recently, the E3 ligase adaptor, autophagy and beclin 1 regulator 1 (AMBRA1), was reported to regulate the stability of CCNDs, including CCND1, but its role in UVM has not been demonstrated. AMBRA1 is lowly expressed in UVM cells, and the ablation of AMBRA1 promotes the proliferation of 92.1 and OMM1 cells, whereas ectopically expressing AMBRA1 attenuates the proliferation of UVM cells. Further studies found that AMBRA1 promotes the ubiquitination and degradation of CCND1, and AMBRA1 regulates the proliferation of UVM cells in a CCND1-dependent manner. Thus, this study suggests that AMBRA1 serves as an important tumor suppressor by limiting UVM cell growth.https://doi.org/10.1515/med-2021-0386uveal melanomaambra1ccnd1ubiquitination |
| spellingShingle | Zhao Binbin Yang Yun Cun Biyun Chen Ping AMBRA1 attenuates the proliferation of uveal melanoma cells Open Medicine uveal melanoma ambra1 ccnd1 ubiquitination |
| title | AMBRA1 attenuates the proliferation of uveal melanoma cells |
| title_full | AMBRA1 attenuates the proliferation of uveal melanoma cells |
| title_fullStr | AMBRA1 attenuates the proliferation of uveal melanoma cells |
| title_full_unstemmed | AMBRA1 attenuates the proliferation of uveal melanoma cells |
| title_short | AMBRA1 attenuates the proliferation of uveal melanoma cells |
| title_sort | ambra1 attenuates the proliferation of uveal melanoma cells |
| topic | uveal melanoma ambra1 ccnd1 ubiquitination |
| url | https://doi.org/10.1515/med-2021-0386 |
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