Influence of the starting day of luteal phase stimulation on double stimulation cycles
BackgroundDouble ovarian stimulation is one of the most used strategies in poor-prognosis patients. There is a high heterogeneity between the studies regarding the execution of this stimulation protocol. The aim of this study was to investigate whether the day on which luteal phase stimulation begin...
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| Format: | Article |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1216671/full |
| _version_ | 1797777977832898560 |
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| author | Ana Fuentes Cristina García-Ajofrín Ruth Romero Juan Carlos Castillo Juan Carlos Castillo Jose A. Ortíz Mónica Hortal Jaime Guerrero Andrea Bernabeu Andrea Bernabeu Rafael Bernabeu Rafael Bernabeu |
| author_facet | Ana Fuentes Cristina García-Ajofrín Ruth Romero Juan Carlos Castillo Juan Carlos Castillo Jose A. Ortíz Mónica Hortal Jaime Guerrero Andrea Bernabeu Andrea Bernabeu Rafael Bernabeu Rafael Bernabeu |
| author_sort | Ana Fuentes |
| collection | DOAJ |
| description | BackgroundDouble ovarian stimulation is one of the most used strategies in poor-prognosis patients. There is a high heterogeneity between the studies regarding the execution of this stimulation protocol. The aim of this study was to investigate whether the day on which luteal phase stimulation begins after the first oocyte retrieval affects ovarian response in DuoStim cycles.MethodsThis observational and retrospective study included 541 DuoStim cycles between January 2018 and December 2021 in a private fertility clinic. Patients were assigned to 4 groups according to the timing of the onset of luteal phase stimulation after oocyte retrieval (0-2nd day, 3rd day, 4th day and 5th-6th day). The primary outcome was the number of oocytes retrieved in the luteal phase in each group.ResultsNo differences were found between groups in the number of oocytes collected (5.12 ± 3.56 vs. 5.39 ± 3.74 vs. 5.61 ± 3.94 vs. 5.89 ± 3.92; p=0,6), MII or number of follicles. An increase in the duration of stimulation was found when stimulation started on the 4th day (10.42 ± 2.31 vs. 10.68 ± 2.37 vs. 11.27 ± 2.40 vs. 10.65 ± 2.37 days, p=0,033). A lower number of fertilized oocytes was observed when stimulation began before the fourth day (3.36 ± 2.80 vs. 3.95 ± 2.53 vs. 4.03 ± 2.73 vs. 4.48 ± 3.11; p=0,036). The number of blastocysts was higher when the stimulation started 5-6 days after retrieval (1.82 ± 1.74 vs. 2.13 ± 1.61 vs. 2.33 ± 2.06 vs. 2.91 ± 2.39; p= 0,030).DiscussionThe number of oocytes retrieved does not differ depending on the day that stimulation begins. However, oocytes competence in terms of fertilized oocytes and blastulation, appears to be lower when the second stimulation starts before the fourth day after oocyte retrieval. |
| first_indexed | 2024-03-12T23:11:41Z |
| format | Article |
| id | doaj.art-8cb9004cbb4e40dc9a44642a4b43ada3 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T23:11:41Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-8cb9004cbb4e40dc9a44642a4b43ada32023-07-18T03:27:35ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-07-011410.3389/fendo.2023.12166711216671Influence of the starting day of luteal phase stimulation on double stimulation cyclesAna Fuentes0Cristina García-Ajofrín1Ruth Romero2Juan Carlos Castillo3Juan Carlos Castillo4Jose A. Ortíz5Mónica Hortal6Jaime Guerrero7Andrea Bernabeu8Andrea Bernabeu9Rafael Bernabeu10Rafael Bernabeu11Department of Reproductive Medicine, Instituto Bernabeu, Alicante, SpainDepartment of Reproductive Medicine, Instituto Bernabeu Madrid, Madrid, SpainDepartment of Reproductive Medicine, Instituto Bernabeu Madrid, Madrid, SpainDepartment of Reproductive Medicine, Instituto Bernabeu, Alicante, SpainCátedra de Medicina Comunitaria y Salud Reproductiva, Universidad Miguel Hernández, Elche, SpainDepartment of Molecular Biology, Instituto Bernabeu BIOTECH, Alicante, SpainDepartment of Molecular Biology, Instituto Bernabeu BIOTECH, Alicante, SpainDepartment of Embryology, Instituto Bernabeu, Alicante, SpainDepartment of Reproductive Medicine, Instituto Bernabeu, Alicante, SpainCátedra de Medicina Comunitaria y Salud Reproductiva, Universidad Miguel Hernández, Elche, SpainDepartment of Reproductive Medicine, Instituto Bernabeu, Alicante, SpainCátedra de Medicina Comunitaria y Salud Reproductiva, Universidad Miguel Hernández, Elche, SpainBackgroundDouble ovarian stimulation is one of the most used strategies in poor-prognosis patients. There is a high heterogeneity between the studies regarding the execution of this stimulation protocol. The aim of this study was to investigate whether the day on which luteal phase stimulation begins after the first oocyte retrieval affects ovarian response in DuoStim cycles.MethodsThis observational and retrospective study included 541 DuoStim cycles between January 2018 and December 2021 in a private fertility clinic. Patients were assigned to 4 groups according to the timing of the onset of luteal phase stimulation after oocyte retrieval (0-2nd day, 3rd day, 4th day and 5th-6th day). The primary outcome was the number of oocytes retrieved in the luteal phase in each group.ResultsNo differences were found between groups in the number of oocytes collected (5.12 ± 3.56 vs. 5.39 ± 3.74 vs. 5.61 ± 3.94 vs. 5.89 ± 3.92; p=0,6), MII or number of follicles. An increase in the duration of stimulation was found when stimulation started on the 4th day (10.42 ± 2.31 vs. 10.68 ± 2.37 vs. 11.27 ± 2.40 vs. 10.65 ± 2.37 days, p=0,033). A lower number of fertilized oocytes was observed when stimulation began before the fourth day (3.36 ± 2.80 vs. 3.95 ± 2.53 vs. 4.03 ± 2.73 vs. 4.48 ± 3.11; p=0,036). The number of blastocysts was higher when the stimulation started 5-6 days after retrieval (1.82 ± 1.74 vs. 2.13 ± 1.61 vs. 2.33 ± 2.06 vs. 2.91 ± 2.39; p= 0,030).DiscussionThe number of oocytes retrieved does not differ depending on the day that stimulation begins. However, oocytes competence in terms of fertilized oocytes and blastulation, appears to be lower when the second stimulation starts before the fourth day after oocyte retrieval.https://www.frontiersin.org/articles/10.3389/fendo.2023.1216671/fulldouble stimulationluteal phase stimulationDuoStimoocyte yieldstart of stimulation |
| spellingShingle | Ana Fuentes Cristina García-Ajofrín Ruth Romero Juan Carlos Castillo Juan Carlos Castillo Jose A. Ortíz Mónica Hortal Jaime Guerrero Andrea Bernabeu Andrea Bernabeu Rafael Bernabeu Rafael Bernabeu Influence of the starting day of luteal phase stimulation on double stimulation cycles Frontiers in Endocrinology double stimulation luteal phase stimulation DuoStim oocyte yield start of stimulation |
| title | Influence of the starting day of luteal phase stimulation on double stimulation cycles |
| title_full | Influence of the starting day of luteal phase stimulation on double stimulation cycles |
| title_fullStr | Influence of the starting day of luteal phase stimulation on double stimulation cycles |
| title_full_unstemmed | Influence of the starting day of luteal phase stimulation on double stimulation cycles |
| title_short | Influence of the starting day of luteal phase stimulation on double stimulation cycles |
| title_sort | influence of the starting day of luteal phase stimulation on double stimulation cycles |
| topic | double stimulation luteal phase stimulation DuoStim oocyte yield start of stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1216671/full |
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