Impact of Ovarian Metastatectomy on Survival Outcome of Colorectal Cancer Patients with Ovarian Metastasis: A Retrospective Study
Xiaofen Li,1 Hai Huang,1,2 Longyao Ran,3 Chao Fang,4 Yongyang Yu,4 Manxi Luo,5 Meng Qiu1 1Department of Abdominal Oncology, West China Hospital of Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Department of Oncology, People’s Hospital of Deyang City...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-06-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/impact-of-ovarian-metastatectomy-on-survival-outcome-of-colorectal-can-peer-reviewed-article-CMAR |
| _version_ | 1818551128886870016 |
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| author | Li X Huang H Ran L Fang C Yu Y Luo M Qiu M |
| author_facet | Li X Huang H Ran L Fang C Yu Y Luo M Qiu M |
| author_sort | Li X |
| collection | DOAJ |
| description | Xiaofen Li,1 Hai Huang,1,2 Longyao Ran,3 Chao Fang,4 Yongyang Yu,4 Manxi Luo,5 Meng Qiu1 1Department of Abdominal Oncology, West China Hospital of Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Department of Oncology, People’s Hospital of Deyang City, Deyang, Sichuan, People’s Republic of China; 3Department of Medical Administration, West China Hospital of Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Department of Gastrointestinal Surgery, West China Hospital of Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 5Faculty of Medicine, The University of New South Wales, Kensington, New South Wales, AustraliaCorrespondence: Meng QiuDepartment of Abdominal Oncology, West China Hospital of Medicine, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, People’s Republic of ChinaTel + 86-28-85422589Fax + 86-28-85423609Email qiumeng33@hotmail.comBackground: Ovarian metastasis from colorectal cancer (CRC) is rare and lacks standard treatment. The benefit of metastatectomy remains to be elucidated. This study was conducted to assess the impact of metastatectomy on survival outcome and explore prognostic factors in ovarian metastatic CRC patients.Methods: Information of ovarian metastatic CRC patients between January 2008 and December 2017 were collected retrospectively from database of West China Hospital, Sichuan University. Kaplan–Meier method was used to estimate disease-specific survival (DSS) after diagnosis of ovarian metastasis, and multivariate Cox regression analysis was applied to identify prognostic factors.Results: Totally, 68 female patients from a cohort of 2170 cases were eligible. The median age at diagnosis was 46.5 years. The median DSS was 25.0 months (95% confidence interval (CI): 21.0– 29.0 months). Kaplan–Meier analysis and Log rank test showed that complete resection of ovarian metastases (median DSS: 33.0 months) could significantly prolong patients’ survival time, compared with palliative and no resection (median DSS: 20.0 months and 22.0 months, respectively), regardless of systemic chemotherapy (P< 0.05). Multivariate analysis demonstrated regional lymph nodes metastasis of primary tumor (hazard ratio (HR): 3.438, 95% CI: 1.094– 10.810, P=0.035), primary tumor resection (HR: 6.436, 95% CI: 1.770– 23.399, P=0.005), differentiation grade (HR: 0.272, 95% CI: 0.107– 0.693, P=0.006), complete resection of ovarian metastases (vs palliative resection: HR: 17.091, 95% CI: 3.040– 96.099, P=0.001; vs no resection: HR: 9.519, 95% CI: 1.581– 57.320, P=0.014), and systemic chemotherapy (HR: 3.059, 95% CI: 1.089– 8.595 P=0.034) were independent prognostic factors.Conclusion: Complete resection of ovarian metastases could independently predict favorable survival in ovarian metastatic CRC, while palliative resection could not improve patients’ prognosis compared with no resection.Keywords: ovarian metastasis, colorectal cancer, metastatectomy |
| first_indexed | 2024-12-12T08:55:45Z |
| format | Article |
| id | doaj.art-8cb96a16401e4c898c3435417ea16648 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-12T08:55:45Z |
| publishDate | 2020-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-8cb96a16401e4c898c3435417ea166482022-12-22T00:30:00ZengDove Medical PressCancer Management and Research1179-13222020-06-01Volume 124493450154489Impact of Ovarian Metastatectomy on Survival Outcome of Colorectal Cancer Patients with Ovarian Metastasis: A Retrospective StudyLi XHuang HRan LFang CYu YLuo MQiu MXiaofen Li,1 Hai Huang,1,2 Longyao Ran,3 Chao Fang,4 Yongyang Yu,4 Manxi Luo,5 Meng Qiu1 1Department of Abdominal Oncology, West China Hospital of Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Department of Oncology, People’s Hospital of Deyang City, Deyang, Sichuan, People’s Republic of China; 3Department of Medical Administration, West China Hospital of Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 4Department of Gastrointestinal Surgery, West China Hospital of Medicine, Sichuan University, Chengdu, Sichuan, People’s Republic of China; 5Faculty of Medicine, The University of New South Wales, Kensington, New South Wales, AustraliaCorrespondence: Meng QiuDepartment of Abdominal Oncology, West China Hospital of Medicine, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan 610041, People’s Republic of ChinaTel + 86-28-85422589Fax + 86-28-85423609Email qiumeng33@hotmail.comBackground: Ovarian metastasis from colorectal cancer (CRC) is rare and lacks standard treatment. The benefit of metastatectomy remains to be elucidated. This study was conducted to assess the impact of metastatectomy on survival outcome and explore prognostic factors in ovarian metastatic CRC patients.Methods: Information of ovarian metastatic CRC patients between January 2008 and December 2017 were collected retrospectively from database of West China Hospital, Sichuan University. Kaplan–Meier method was used to estimate disease-specific survival (DSS) after diagnosis of ovarian metastasis, and multivariate Cox regression analysis was applied to identify prognostic factors.Results: Totally, 68 female patients from a cohort of 2170 cases were eligible. The median age at diagnosis was 46.5 years. The median DSS was 25.0 months (95% confidence interval (CI): 21.0– 29.0 months). Kaplan–Meier analysis and Log rank test showed that complete resection of ovarian metastases (median DSS: 33.0 months) could significantly prolong patients’ survival time, compared with palliative and no resection (median DSS: 20.0 months and 22.0 months, respectively), regardless of systemic chemotherapy (P< 0.05). Multivariate analysis demonstrated regional lymph nodes metastasis of primary tumor (hazard ratio (HR): 3.438, 95% CI: 1.094– 10.810, P=0.035), primary tumor resection (HR: 6.436, 95% CI: 1.770– 23.399, P=0.005), differentiation grade (HR: 0.272, 95% CI: 0.107– 0.693, P=0.006), complete resection of ovarian metastases (vs palliative resection: HR: 17.091, 95% CI: 3.040– 96.099, P=0.001; vs no resection: HR: 9.519, 95% CI: 1.581– 57.320, P=0.014), and systemic chemotherapy (HR: 3.059, 95% CI: 1.089– 8.595 P=0.034) were independent prognostic factors.Conclusion: Complete resection of ovarian metastases could independently predict favorable survival in ovarian metastatic CRC, while palliative resection could not improve patients’ prognosis compared with no resection.Keywords: ovarian metastasis, colorectal cancer, metastatectomyhttps://www.dovepress.com/impact-of-ovarian-metastatectomy-on-survival-outcome-of-colorectal-can-peer-reviewed-article-CMARovarian metastasiscolorectal cancermetastatectomy |
| spellingShingle | Li X Huang H Ran L Fang C Yu Y Luo M Qiu M Impact of Ovarian Metastatectomy on Survival Outcome of Colorectal Cancer Patients with Ovarian Metastasis: A Retrospective Study Cancer Management and Research ovarian metastasis colorectal cancer metastatectomy |
| title | Impact of Ovarian Metastatectomy on Survival Outcome of Colorectal Cancer Patients with Ovarian Metastasis: A Retrospective Study |
| title_full | Impact of Ovarian Metastatectomy on Survival Outcome of Colorectal Cancer Patients with Ovarian Metastasis: A Retrospective Study |
| title_fullStr | Impact of Ovarian Metastatectomy on Survival Outcome of Colorectal Cancer Patients with Ovarian Metastasis: A Retrospective Study |
| title_full_unstemmed | Impact of Ovarian Metastatectomy on Survival Outcome of Colorectal Cancer Patients with Ovarian Metastasis: A Retrospective Study |
| title_short | Impact of Ovarian Metastatectomy on Survival Outcome of Colorectal Cancer Patients with Ovarian Metastasis: A Retrospective Study |
| title_sort | impact of ovarian metastatectomy on survival outcome of colorectal cancer patients with ovarian metastasis a retrospective study |
| topic | ovarian metastasis colorectal cancer metastatectomy |
| url | https://www.dovepress.com/impact-of-ovarian-metastatectomy-on-survival-outcome-of-colorectal-can-peer-reviewed-article-CMAR |
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