The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters
This study investigated the anti-obesity effect of a polysaccharide-rich red algae <i>Gelidium amansii</i> hot-water extract (GHE) in high-fat (HF) diet-induced obese hamsters. GHE contained 68.54% water-soluble indigestible carbohydrate polymers. Hamsters were fed with a HF diet for 5 w...
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MDPI AG
2019-09-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/9/532 |
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| author | Tsung-Han Yang Chen-Yuan Chiu Ting-Jang Lu Shing-Hwa Liu Meng-Tsan Chiang |
| author_facet | Tsung-Han Yang Chen-Yuan Chiu Ting-Jang Lu Shing-Hwa Liu Meng-Tsan Chiang |
| author_sort | Tsung-Han Yang |
| collection | DOAJ |
| description | This study investigated the anti-obesity effect of a polysaccharide-rich red algae <i>Gelidium amansii</i> hot-water extract (GHE) in high-fat (HF) diet-induced obese hamsters. GHE contained 68.54% water-soluble indigestible carbohydrate polymers. Hamsters were fed with a HF diet for 5 weeks to induce obesity, and then randomly divided into: HF group, HF with 3% guar gum diet group, HF with 3% GHE diet group, and HF with orlistat (200 mg/kg diet) group for 9 weeks. The increased weights of body, liver, and adipose in the HF group were significantly reversed by GHE supplementation. Lower plasma leptin, tumor necrosis factor-α, and interleukin-6 levels were observed in the GHE+HF group compared to the HF group. GHE also increased the lipolysis rate and decreased the lipoprotein lipase activity in adipose tissues. GHE induced an increase in the phosphorylation of AMP-activated protein kinase (AMPK) and the protein expressions of peroxisome proliferator-activated receptor alpha (PPARα) and uncoupling protein (UCP)-2 in the livers. The decreased triglyceride and total cholesterol in the plasma and liver were also observed in obese hamsters fed a diet with GHE. These results suggest that GHE exerts a down-regulation effect on hepatic lipid metabolism through AMPK phosphorylation and up-regulation of PPARα and UCP-2 in HF-induced obese hamsters. |
| first_indexed | 2024-04-14T01:29:10Z |
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| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-14T01:29:10Z |
| publishDate | 2019-09-01 |
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| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-8cb9f6fd68d849eab78c0cd481feab6a2022-12-22T02:20:17ZengMDPI AGMarine Drugs1660-33972019-09-0117953210.3390/md17090532md17090532The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts in High-Fat Diet-Induced Obese HamstersTsung-Han Yang0Chen-Yuan Chiu1Ting-Jang Lu2Shing-Hwa Liu3Meng-Tsan Chiang4Department of Food Science, National Taiwan Ocean University, Keelung 20224, TaiwanMedical and Pharmaceutical Industry Technology and Development Center, New Taipei City 24886, TaiwanInstitute of Food Science and Technology, National Taiwan University, Taipei 10617, TaiwanGraduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, TaiwanDepartment of Food Science, National Taiwan Ocean University, Keelung 20224, TaiwanThis study investigated the anti-obesity effect of a polysaccharide-rich red algae <i>Gelidium amansii</i> hot-water extract (GHE) in high-fat (HF) diet-induced obese hamsters. GHE contained 68.54% water-soluble indigestible carbohydrate polymers. Hamsters were fed with a HF diet for 5 weeks to induce obesity, and then randomly divided into: HF group, HF with 3% guar gum diet group, HF with 3% GHE diet group, and HF with orlistat (200 mg/kg diet) group for 9 weeks. The increased weights of body, liver, and adipose in the HF group were significantly reversed by GHE supplementation. Lower plasma leptin, tumor necrosis factor-α, and interleukin-6 levels were observed in the GHE+HF group compared to the HF group. GHE also increased the lipolysis rate and decreased the lipoprotein lipase activity in adipose tissues. GHE induced an increase in the phosphorylation of AMP-activated protein kinase (AMPK) and the protein expressions of peroxisome proliferator-activated receptor alpha (PPARα) and uncoupling protein (UCP)-2 in the livers. The decreased triglyceride and total cholesterol in the plasma and liver were also observed in obese hamsters fed a diet with GHE. These results suggest that GHE exerts a down-regulation effect on hepatic lipid metabolism through AMPK phosphorylation and up-regulation of PPARα and UCP-2 in HF-induced obese hamsters.https://www.mdpi.com/1660-3397/17/9/532<i>Gelidium amansii</i> hot-water extractsguar gumorlistatobesityadipocytokineslipoprotein lipase |
| spellingShingle | Tsung-Han Yang Chen-Yuan Chiu Ting-Jang Lu Shing-Hwa Liu Meng-Tsan Chiang The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters Marine Drugs <i>Gelidium amansii</i> hot-water extracts guar gum orlistat obesity adipocytokines lipoprotein lipase |
| title | The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters |
| title_full | The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters |
| title_fullStr | The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters |
| title_full_unstemmed | The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters |
| title_short | The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (<i>Gelidium amansii</i>) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters |
| title_sort | anti obesity effect of polysaccharide rich red algae i gelidium amansii i hot water extracts in high fat diet induced obese hamsters |
| topic | <i>Gelidium amansii</i> hot-water extracts guar gum orlistat obesity adipocytokines lipoprotein lipase |
| url | https://www.mdpi.com/1660-3397/17/9/532 |
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