The epidemiology of infective endocarditis with focus on non-device related right-sided infective endocarditis: A retrospective register-based study in the region of Southern Denmark
Aims: Non-device related right-sided infective endocarditis (ND-RSIE) is not well characterized. We aimed to characterize patients with infective endocarditis (IE) with emphasis on the epidemiology, clinical characteristics and complications of ND-RSIE. Methods: In this population-based cohort study...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971220302277 |
| _version_ | 1828769641751642112 |
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| author | Helena Lassen Stig Lønberg Nielsen Sabine Ute Alice Gill Isik Somuncu Johansen |
| author_facet | Helena Lassen Stig Lønberg Nielsen Sabine Ute Alice Gill Isik Somuncu Johansen |
| author_sort | Helena Lassen |
| collection | DOAJ |
| description | Aims: Non-device related right-sided infective endocarditis (ND-RSIE) is not well characterized. We aimed to characterize patients with infective endocarditis (IE) with emphasis on the epidemiology, clinical characteristics and complications of ND-RSIE. Methods: In this population-based cohort study, we identified patients with IE using ICD-10 codes from the Danish National Hospital Register in the Region of Southern Denmark between January 2007 and May 2017. Hospital records were reviewed, and characteristics and outcomes recorded. Results: We included 1243 confirmed IE episodes of which 82% were left-sided IE, 11% were cardiac device right sided infective endocarditis (RSIE) and 7% were ND-RSIE. Patients with ND-RSIE were considerably younger, had less comorbidity and had a lower 30-day mortality (6%) compared with patients with device RSIE (24%) and left-sided IE (26%) (p < 0.01). ND-RSIE was associated with underlying heart disease, involvement of the tricuspid valve (57%), Staphylococcus species (53%) and complications (61%). Forty percent of ND-RSIE occurred among people who inject drugs (PWID) for whom significant differences were observed compared with non-PWID with regards to tricuspid valve involvement (96% vs. 32%), causative microorganisms (Staphylococcus aureus 79% vs. 27%), complications (86% vs. 45%), recurrence (29% vs. 11%) and 30-day mortality (0% vs. 7%). Conclusion: ND-RSIE is relatively rare and differs with regards to epidemiology, clinical characteristics and complications compared with left-sided IE and cardiac device RSIE, but has a favourable prognosis. Forty percent of ND-RSIE occurs among PWID, which is associated with frequent complications but a very low mortality. |
| first_indexed | 2024-12-11T13:52:34Z |
| format | Article |
| id | doaj.art-8cbaeed06dbc4d82ab50c1fe8a863fa9 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-11T13:52:34Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-8cbaeed06dbc4d82ab50c1fe8a863fa92022-12-22T01:04:13ZengElsevierInternational Journal of Infectious Diseases1201-97122020-06-0195224230The epidemiology of infective endocarditis with focus on non-device related right-sided infective endocarditis: A retrospective register-based study in the region of Southern DenmarkHelena Lassen0Stig Lønberg Nielsen1Sabine Ute Alice Gill2Isik Somuncu Johansen3Department of Infectious Diseases, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, Denmark; OPEN, Open Patient data Explorative Network, Odense University Hospital, J. B. Winsløws Vej 9A, 5000 Odense C, Denmark; Corresponding author at: Department of Infectious Diseases, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, Denmark. Tel.: +45 61665754; fax: +45 65413022.Department of Infectious Diseases, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, DenmarkDepartment of Cardiology, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, DenmarkDepartment of Infectious Diseases, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense C, Denmark; OPEN, Open Patient data Explorative Network, Odense University Hospital, J. B. Winsløws Vej 9A, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 5000 Odense C, DenmarkAims: Non-device related right-sided infective endocarditis (ND-RSIE) is not well characterized. We aimed to characterize patients with infective endocarditis (IE) with emphasis on the epidemiology, clinical characteristics and complications of ND-RSIE. Methods: In this population-based cohort study, we identified patients with IE using ICD-10 codes from the Danish National Hospital Register in the Region of Southern Denmark between January 2007 and May 2017. Hospital records were reviewed, and characteristics and outcomes recorded. Results: We included 1243 confirmed IE episodes of which 82% were left-sided IE, 11% were cardiac device right sided infective endocarditis (RSIE) and 7% were ND-RSIE. Patients with ND-RSIE were considerably younger, had less comorbidity and had a lower 30-day mortality (6%) compared with patients with device RSIE (24%) and left-sided IE (26%) (p < 0.01). ND-RSIE was associated with underlying heart disease, involvement of the tricuspid valve (57%), Staphylococcus species (53%) and complications (61%). Forty percent of ND-RSIE occurred among people who inject drugs (PWID) for whom significant differences were observed compared with non-PWID with regards to tricuspid valve involvement (96% vs. 32%), causative microorganisms (Staphylococcus aureus 79% vs. 27%), complications (86% vs. 45%), recurrence (29% vs. 11%) and 30-day mortality (0% vs. 7%). Conclusion: ND-RSIE is relatively rare and differs with regards to epidemiology, clinical characteristics and complications compared with left-sided IE and cardiac device RSIE, but has a favourable prognosis. Forty percent of ND-RSIE occurs among PWID, which is associated with frequent complications but a very low mortality.http://www.sciencedirect.com/science/article/pii/S1201971220302277Infective endocarditisIntravenous drug abuseMortalityBacteremiaEpidemiology |
| spellingShingle | Helena Lassen Stig Lønberg Nielsen Sabine Ute Alice Gill Isik Somuncu Johansen The epidemiology of infective endocarditis with focus on non-device related right-sided infective endocarditis: A retrospective register-based study in the region of Southern Denmark International Journal of Infectious Diseases Infective endocarditis Intravenous drug abuse Mortality Bacteremia Epidemiology |
| title | The epidemiology of infective endocarditis with focus on non-device related right-sided infective endocarditis: A retrospective register-based study in the region of Southern Denmark |
| title_full | The epidemiology of infective endocarditis with focus on non-device related right-sided infective endocarditis: A retrospective register-based study in the region of Southern Denmark |
| title_fullStr | The epidemiology of infective endocarditis with focus on non-device related right-sided infective endocarditis: A retrospective register-based study in the region of Southern Denmark |
| title_full_unstemmed | The epidemiology of infective endocarditis with focus on non-device related right-sided infective endocarditis: A retrospective register-based study in the region of Southern Denmark |
| title_short | The epidemiology of infective endocarditis with focus on non-device related right-sided infective endocarditis: A retrospective register-based study in the region of Southern Denmark |
| title_sort | epidemiology of infective endocarditis with focus on non device related right sided infective endocarditis a retrospective register based study in the region of southern denmark |
| topic | Infective endocarditis Intravenous drug abuse Mortality Bacteremia Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220302277 |
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