Rhabdomyolysis in a patient taking nebivolol
β Blockers such as propranolol and labetalol are known to induce toxic myopathy because of their partial β2 adrenoceptor agonistic effect. Nebivolol has the highest β1 receptor affinity among β blockers, and it has never been reported to induce rhabdomyolysis until now. We report a patient who devel...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Nephrology
2016-09-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211913215300024 |
| _version_ | 1828418525159489536 |
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| author | Ye Jin Kim Hae Ri Kim Hong Jae Jeon Hyun Jun Ju Sarah Chung Dae Eun Choi Kang Wook Lee Ki Ryang Na |
| author_facet | Ye Jin Kim Hae Ri Kim Hong Jae Jeon Hyun Jun Ju Sarah Chung Dae Eun Choi Kang Wook Lee Ki Ryang Na |
| author_sort | Ye Jin Kim |
| collection | DOAJ |
| description | β Blockers such as propranolol and labetalol are known to induce toxic myopathy because of their partial β2 adrenoceptor agonistic effect. Nebivolol has the highest β1 receptor affinity among β blockers, and it has never been reported to induce rhabdomyolysis until now. We report a patient who developed rhabdomyolysis after changing medication to nebivolol. A 75-year-old woman was admitted to our hospital because of generalized weakness originating 2 weeks before visiting. Approximately 1 month before her admission, her medication was changed from carvedilol 12.5 mg to nebivolol 5 mg. Over this time span, she had no other lifestyle changes causing rhabdomyolysis. Her blood chemistry and whole body bone scan indicated rhabdomyolysis. We considered newly prescribed nebivolol as a causal agent. She was prescribed carvedilol 12.5 mg, which she was previously taking, instead of nebivolol. She was treated by hydration and urine alkalization. She had fully recovered and was discharged. |
| first_indexed | 2024-12-10T14:38:19Z |
| format | Article |
| id | doaj.art-8cbc0f950a4e4f3ca199a8bf633731a6 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-10T14:38:19Z |
| publishDate | 2016-09-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-8cbc0f950a4e4f3ca199a8bf633731a62022-12-22T01:44:45ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322016-09-0135318218610.1016/j.krcp.2015.09.003Rhabdomyolysis in a patient taking nebivololYe Jin KimHae Ri KimHong Jae JeonHyun Jun JuSarah ChungDae Eun ChoiKang Wook LeeKi Ryang Naβ Blockers such as propranolol and labetalol are known to induce toxic myopathy because of their partial β2 adrenoceptor agonistic effect. Nebivolol has the highest β1 receptor affinity among β blockers, and it has never been reported to induce rhabdomyolysis until now. We report a patient who developed rhabdomyolysis after changing medication to nebivolol. A 75-year-old woman was admitted to our hospital because of generalized weakness originating 2 weeks before visiting. Approximately 1 month before her admission, her medication was changed from carvedilol 12.5 mg to nebivolol 5 mg. Over this time span, she had no other lifestyle changes causing rhabdomyolysis. Her blood chemistry and whole body bone scan indicated rhabdomyolysis. We considered newly prescribed nebivolol as a causal agent. She was prescribed carvedilol 12.5 mg, which she was previously taking, instead of nebivolol. She was treated by hydration and urine alkalization. She had fully recovered and was discharged.http://www.sciencedirect.com/science/article/pii/S2211913215300024β-adrenergic blockersMyopathiesNebivololRhabdomyolysis |
| spellingShingle | Ye Jin Kim Hae Ri Kim Hong Jae Jeon Hyun Jun Ju Sarah Chung Dae Eun Choi Kang Wook Lee Ki Ryang Na Rhabdomyolysis in a patient taking nebivolol Kidney Research and Clinical Practice β-adrenergic blockers Myopathies Nebivolol Rhabdomyolysis |
| title | Rhabdomyolysis in a patient taking nebivolol |
| title_full | Rhabdomyolysis in a patient taking nebivolol |
| title_fullStr | Rhabdomyolysis in a patient taking nebivolol |
| title_full_unstemmed | Rhabdomyolysis in a patient taking nebivolol |
| title_short | Rhabdomyolysis in a patient taking nebivolol |
| title_sort | rhabdomyolysis in a patient taking nebivolol |
| topic | β-adrenergic blockers Myopathies Nebivolol Rhabdomyolysis |
| url | http://www.sciencedirect.com/science/article/pii/S2211913215300024 |
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