Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA

Size- and Surface- Dual Engineered Small Polyplexes for Efficiently Targeting Delivery of siRNA

Though siRNA-based therapy has achieved great progress, efficient siRNA delivery remains a challenge. Here, we synthesized a copolymer PAsp(-N=C-PEG)-PCys-PAsp(DETA) consisting of a poly(aspartate) block grafted with comb-like PEG side chains via a pH-sensitive imine bond (PAsp(-N=C-PEG) block), a p...

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Bibliographic Details
Main Authors: Shuang Liu, Shaohui Deng, Xiaoxia Li, Du Cheng
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
small polyplex
pH-sensitive PEG shedding
disulfide bond-crosslinking
siRNA delivery
targeting delivery
Online Access:https://www.mdpi.com/1420-3049/26/11/3238

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