Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage

Acid Sphingomyelinase Inhibition Prevents Hemolysis During Erythrocyte Storage

Background/Aims: During storage, units of human red blood cells (pRBCs) experience membrane destabilization and hemolysis which may cause harm to transfusion recipients. This study investigates whether inhibition of acid sphingomyelinase could stabilize erythrocyte membranes and prevent hemolysis du...

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Bibliographic Details
Main Authors: Richard S. Hoehn, Peter L. Jernigan, Alex L. Chang, Michael J. Edwards, Charles C. Caldwell, Erich Gulbins, Timothy A. Pritts
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Sphingomyelinase
Blood banking
Storage lesion
Hemolysis
Online Access:http://www.karger.com/Article/FullText/445627

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