Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate
Human nail diseases, mostly caused by fungal infections, are common and difficult to treat. The development and testing of new drugs and drug delivery systems for the treatment of nail diseases is often limited by the lack of human nail material for permeation studies. Animal material is frequently...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/12/2552 |
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| author | Dorota Dobler Mona Gerber Thomas M. Schmidts Frank Runkel Peggy Schlupp |
| author_facet | Dorota Dobler Mona Gerber Thomas M. Schmidts Frank Runkel Peggy Schlupp |
| author_sort | Dorota Dobler |
| collection | DOAJ |
| description | Human nail diseases, mostly caused by fungal infections, are common and difficult to treat. The development and testing of new drugs and drug delivery systems for the treatment of nail diseases is often limited by the lack of human nail material for permeation studies. Animal material is frequently used, but there are only few comparative data on the human nail plate, and there is neither a standardized test design nor a nail bed analogue to study drug uptake into the nail. In this study, a new permeation device was developed for permeation studies, and the permeation behavior of three model substances on the human nail plate and a model membrane from the horse hoof was investigated. A linear correlation was found between drug uptake by the human nail plate and the uptake by the equine hoof. The developed and established permeation device is suitable for investigations of ungual drug transport and enables the use of different membrane diameters and the use of a gel-based nail bed analog. The hydrogel-based acceptor medium used ensures adequate stabilization and hydration of the nail membrane. |
| first_indexed | 2024-03-09T15:58:31Z |
| format | Article |
| id | doaj.art-8cbe92adb8a74ac4aa61780ac9e20107 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T15:58:31Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8cbe92adb8a74ac4aa61780ac9e201072023-11-24T17:17:55ZengMDPI AGPharmaceutics1999-49232022-11-011412255210.3390/pharmaceutics14122552Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail PlateDorota Dobler0Mona Gerber1Thomas M. Schmidts2Frank Runkel3Peggy Schlupp4Technische Hochschule Mittelhessen, Institute of Bioprocess Engineering and Pharmaceutical Technology, 35390 Giessen, GermanyTechnische Hochschule Mittelhessen, Institute of Bioprocess Engineering and Pharmaceutical Technology, 35390 Giessen, GermanyTechnische Hochschule Mittelhessen, Institute of Bioprocess Engineering and Pharmaceutical Technology, 35390 Giessen, GermanyTechnische Hochschule Mittelhessen, Institute of Bioprocess Engineering and Pharmaceutical Technology, 35390 Giessen, GermanyTechnische Hochschule Mittelhessen, Institute of Bioprocess Engineering and Pharmaceutical Technology, 35390 Giessen, GermanyHuman nail diseases, mostly caused by fungal infections, are common and difficult to treat. The development and testing of new drugs and drug delivery systems for the treatment of nail diseases is often limited by the lack of human nail material for permeation studies. Animal material is frequently used, but there are only few comparative data on the human nail plate, and there is neither a standardized test design nor a nail bed analogue to study drug uptake into the nail. In this study, a new permeation device was developed for permeation studies, and the permeation behavior of three model substances on the human nail plate and a model membrane from the horse hoof was investigated. A linear correlation was found between drug uptake by the human nail plate and the uptake by the equine hoof. The developed and established permeation device is suitable for investigations of ungual drug transport and enables the use of different membrane diameters and the use of a gel-based nail bed analog. The hydrogel-based acceptor medium used ensures adequate stabilization and hydration of the nail membrane.https://www.mdpi.com/1999-4923/14/12/2552caffeinetestosteronesorbic acidhuman nail plateungual permeationungual penetration |
| spellingShingle | Dorota Dobler Mona Gerber Thomas M. Schmidts Frank Runkel Peggy Schlupp Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate Pharmaceutics caffeine testosterone sorbic acid human nail plate ungual permeation ungual penetration |
| title | Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate |
| title_full | Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate |
| title_fullStr | Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate |
| title_full_unstemmed | Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate |
| title_short | Comparative Ungual Drug Uptake Studies: Equine Hoof Membrane vs. Human Nail Plate |
| title_sort | comparative ungual drug uptake studies equine hoof membrane vs human nail plate |
| topic | caffeine testosterone sorbic acid human nail plate ungual permeation ungual penetration |
| url | https://www.mdpi.com/1999-4923/14/12/2552 |
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