CLINICAL CRITERIA FOR THE OUTCOME FORECAST OF ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDES
Purpose: The wide-spread use of organophosphorus pesticides (OPP) and their substantial toxicity determine the high frequency of poisoning with them. Despite the modern treatment methods, the acute exogenous intoxications (AEI) continue to exhibit high lethality and are the source of one of the most...
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| Format: | Article |
| Language: | English |
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Peytchinski Publishing
2017-05-01
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| Series: | Journal of IMAB |
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| Online Access: | http://www.journal-imab-bg.org/issues-2017/issue2/JofIMAB-2017-23-2p1541-1545.pdf |
| _version_ | 1818595195838529536 |
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| author | Petko Marinov Snezha Zlateva Dobri Ivanov Georgi Bonchev Yulichka Sabeva Kaloyan Georgiev Ivaylo Vazharov |
| author_facet | Petko Marinov Snezha Zlateva Dobri Ivanov Georgi Bonchev Yulichka Sabeva Kaloyan Georgiev Ivaylo Vazharov |
| author_sort | Petko Marinov |
| collection | DOAJ |
| description | Purpose: The wide-spread use of organophosphorus pesticides (OPP) and their substantial toxicity determine the high frequency of poisoning with them. Despite the modern treatment methods, the acute exogenous intoxications (AEI) continue to exhibit high lethality and are the source of one of the most serious problems in the clinical toxicology. A number of not commonly accepted criteria have been suggested to estimate the gravity of the organophosphorous intoxication. Until now no system of clinical criteria exists that would forecast the outcome of this type of acute poisoning. The aim of this study is to develop an outcome forecast of AEI with OPP with the help of basic clinical criteria.
Materials/Methods: The subjects of the study are 160 patients. We explore the significance of five of the most typical clinical indicators of the acute poisoning with OPP for the outcome of the intoxication and the need of artificial pulmonary ventilation, with the aid of discriminatory statistical analysis. The selected indicators form a discriminatory model with automatically built discrimination function.
Results: The obtained classification coefficients allow us to construct a forecast matrix containing score estimates designed for practical applications. |
| first_indexed | 2024-12-16T11:12:10Z |
| format | Article |
| id | doaj.art-8cbf303b43b54fc19c007321c44e7995 |
| institution | Directory Open Access Journal |
| issn | 1312-773X |
| language | English |
| last_indexed | 2024-12-16T11:12:10Z |
| publishDate | 2017-05-01 |
| publisher | Peytchinski Publishing |
| record_format | Article |
| series | Journal of IMAB |
| spelling | doaj.art-8cbf303b43b54fc19c007321c44e79952022-12-21T22:33:42ZengPeytchinski PublishingJournal of IMAB1312-773X2017-05-012321541154510.5272/jimab.2017232.1541CLINICAL CRITERIA FOR THE OUTCOME FORECAST OF ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDESPetko Marinov0Snezha Zlateva1Dobri Ivanov2Georgi Bonchev3Yulichka Sabeva4Kaloyan Georgiev5Ivaylo Vazharov6Clinic for Intensive Treatment of Acute Intoxications and Toxicoallergies, Naval Hospital – Varna, Military Medical Academy, BulgariaClinic for Intensive Treatment of Acute Intoxications and Toxicoallergies, Naval Hospital – Varna, Military Medical Academy, BulgariaDepartment of Biology, Faculty of Pharmacy, Medical University – Varna, BulgariaClinic for Intensive Treatment of Acute Intoxications and Toxicoallergies, Naval Hospital – Varna, Military Medical Academy, BulgariaDepartment of Pharmacology, Toxicology and Pharmacotherapy, Faculty of Pharmacy, Medical University – Varna, Bulgaria Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University – Varna, BulgariaClinic of Internal Diseases, Naval Hospital – Varna, Military Medical Academy, BulgariaPurpose: The wide-spread use of organophosphorus pesticides (OPP) and their substantial toxicity determine the high frequency of poisoning with them. Despite the modern treatment methods, the acute exogenous intoxications (AEI) continue to exhibit high lethality and are the source of one of the most serious problems in the clinical toxicology. A number of not commonly accepted criteria have been suggested to estimate the gravity of the organophosphorous intoxication. Until now no system of clinical criteria exists that would forecast the outcome of this type of acute poisoning. The aim of this study is to develop an outcome forecast of AEI with OPP with the help of basic clinical criteria. Materials/Methods: The subjects of the study are 160 patients. We explore the significance of five of the most typical clinical indicators of the acute poisoning with OPP for the outcome of the intoxication and the need of artificial pulmonary ventilation, with the aid of discriminatory statistical analysis. The selected indicators form a discriminatory model with automatically built discrimination function. Results: The obtained classification coefficients allow us to construct a forecast matrix containing score estimates designed for practical applications.http://www.journal-imab-bg.org/issues-2017/issue2/JofIMAB-2017-23-2p1541-1545.pdforganophosphorus pesticidesacute poisoningprognosis |
| spellingShingle | Petko Marinov Snezha Zlateva Dobri Ivanov Georgi Bonchev Yulichka Sabeva Kaloyan Georgiev Ivaylo Vazharov CLINICAL CRITERIA FOR THE OUTCOME FORECAST OF ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDES Journal of IMAB organophosphorus pesticides acute poisoning prognosis |
| title | CLINICAL CRITERIA FOR THE OUTCOME FORECAST OF ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDES |
| title_full | CLINICAL CRITERIA FOR THE OUTCOME FORECAST OF ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDES |
| title_fullStr | CLINICAL CRITERIA FOR THE OUTCOME FORECAST OF ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDES |
| title_full_unstemmed | CLINICAL CRITERIA FOR THE OUTCOME FORECAST OF ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDES |
| title_short | CLINICAL CRITERIA FOR THE OUTCOME FORECAST OF ACUTE EXOGENOUS INTOXICATIONS WITH ORGANOPHOSPHORUS PESTICIDES |
| title_sort | clinical criteria for the outcome forecast of acute exogenous intoxications with organophosphorus pesticides |
| topic | organophosphorus pesticides acute poisoning prognosis |
| url | http://www.journal-imab-bg.org/issues-2017/issue2/JofIMAB-2017-23-2p1541-1545.pdf |
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