Pharmatherapeutic Treatment of Osteoarthrosis—Does the Pill against Already Exist? A Narrative Review
The aim of this narrative review is to summarize the current pharmacotherapeutic treatment options for osteoarthritis (OA). Is therapy still mainly symptomatic or does the pill against arthrosis already exist? Causal and non-causal, as well as future therapeutic approaches, are discussed. Various su...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/7/1087 |
| _version_ | 1797588708851974144 |
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| author | Frauke Wilken Peter Buschner Christian Benignus Anna-Maria Behr Johannes Rieger Johannes Beckmann |
| author_facet | Frauke Wilken Peter Buschner Christian Benignus Anna-Maria Behr Johannes Rieger Johannes Beckmann |
| author_sort | Frauke Wilken |
| collection | DOAJ |
| description | The aim of this narrative review is to summarize the current pharmacotherapeutic treatment options for osteoarthritis (OA). Is therapy still mainly symptomatic or does the pill against arthrosis already exist? Causal and non-causal, as well as future therapeutic approaches, are discussed. Various surgical and non-surgical treatment options are available that can help manage symptoms, slow down progression, and improve quality of life. To date, however, therapy is still mainly symptomatic, often using painkilling and anti-inflammatory drugs until the final stage, which is usually joint replacement. These “symptomatic pills against” have side effects and do not alter the progression of OA, which is caused by an imbalance between degenerative and regenerative processes. Next to resolving mechanical issues, the goal must be to gain a better understanding of the cellular and molecular basis of OA. Recently, there has been a lot of interest in cartilage-regenerative medicine and in the current style of treating rheumatoid arthritis, where drug therapy (“the pill against”) has been established to slow down or even stop the progression of rheumatoid arthritis and has banned the vast majority of former almost regular severe joint destructions. However, the “causal pill against” OA does not exist so far. First, the early detection of osteoarthritis by means of biomarkers and imaging should therefore gain more focus. Second, future therapeutic approaches have to identify innovative therapeutic approaches influencing inflammatory and metabolic processes. Several pharmacologic, genetic, and even epigenetic attempts are promising, but none have clinically improved causal therapy so far, unfortunately. |
| first_indexed | 2024-03-11T00:55:51Z |
| format | Article |
| id | doaj.art-8cc0f6119660475fb9876b4698e8f2c3 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T00:55:51Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-8cc0f6119660475fb9876b4698e8f2c32023-11-18T20:03:24ZengMDPI AGJournal of Personalized Medicine2075-44262023-06-01137108710.3390/jpm13071087Pharmatherapeutic Treatment of Osteoarthrosis—Does the Pill against Already Exist? A Narrative ReviewFrauke Wilken0Peter Buschner1Christian Benignus2Anna-Maria Behr3Johannes Rieger4Johannes Beckmann5Department of Orthopedic Surgery and Traumatology, Hospital Barmherzige Brüder Munich, Romanstr. 93, 80639 München, GermanyDepartment of Orthopedic Surgery and Traumatology, Hospital Barmherzige Brüder Munich, Romanstr. 93, 80639 München, GermanyDepartment of Traumatology and Orthopedic Surgery, Hospital Ludwigsburg, Posilipostr. 4, 71640 Ludwigsburg, GermanyDepartment of Orthopedic Surgery and Traumatology, Hospital Barmherzige Brüder Munich, Romanstr. 93, 80639 München, GermanyDepartment of Orthopedic Surgery and Traumatology, Hospital Barmherzige Brüder Munich, Romanstr. 93, 80639 München, GermanyDepartment of Orthopedic Surgery and Traumatology, Hospital Barmherzige Brüder Munich, Romanstr. 93, 80639 München, GermanyThe aim of this narrative review is to summarize the current pharmacotherapeutic treatment options for osteoarthritis (OA). Is therapy still mainly symptomatic or does the pill against arthrosis already exist? Causal and non-causal, as well as future therapeutic approaches, are discussed. Various surgical and non-surgical treatment options are available that can help manage symptoms, slow down progression, and improve quality of life. To date, however, therapy is still mainly symptomatic, often using painkilling and anti-inflammatory drugs until the final stage, which is usually joint replacement. These “symptomatic pills against” have side effects and do not alter the progression of OA, which is caused by an imbalance between degenerative and regenerative processes. Next to resolving mechanical issues, the goal must be to gain a better understanding of the cellular and molecular basis of OA. Recently, there has been a lot of interest in cartilage-regenerative medicine and in the current style of treating rheumatoid arthritis, where drug therapy (“the pill against”) has been established to slow down or even stop the progression of rheumatoid arthritis and has banned the vast majority of former almost regular severe joint destructions. However, the “causal pill against” OA does not exist so far. First, the early detection of osteoarthritis by means of biomarkers and imaging should therefore gain more focus. Second, future therapeutic approaches have to identify innovative therapeutic approaches influencing inflammatory and metabolic processes. Several pharmacologic, genetic, and even epigenetic attempts are promising, but none have clinically improved causal therapy so far, unfortunately.https://www.mdpi.com/2075-4426/13/7/1087osteoarthritiscartilagechondroprotectorsplatelet rich plasmaNSAIDsmesenchymal stem cells |
| spellingShingle | Frauke Wilken Peter Buschner Christian Benignus Anna-Maria Behr Johannes Rieger Johannes Beckmann Pharmatherapeutic Treatment of Osteoarthrosis—Does the Pill against Already Exist? A Narrative Review Journal of Personalized Medicine osteoarthritis cartilage chondroprotectors platelet rich plasma NSAIDs mesenchymal stem cells |
| title | Pharmatherapeutic Treatment of Osteoarthrosis—Does the Pill against Already Exist? A Narrative Review |
| title_full | Pharmatherapeutic Treatment of Osteoarthrosis—Does the Pill against Already Exist? A Narrative Review |
| title_fullStr | Pharmatherapeutic Treatment of Osteoarthrosis—Does the Pill against Already Exist? A Narrative Review |
| title_full_unstemmed | Pharmatherapeutic Treatment of Osteoarthrosis—Does the Pill against Already Exist? A Narrative Review |
| title_short | Pharmatherapeutic Treatment of Osteoarthrosis—Does the Pill against Already Exist? A Narrative Review |
| title_sort | pharmatherapeutic treatment of osteoarthrosis does the pill against already exist a narrative review |
| topic | osteoarthritis cartilage chondroprotectors platelet rich plasma NSAIDs mesenchymal stem cells |
| url | https://www.mdpi.com/2075-4426/13/7/1087 |
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