Antibacterial, photothermal and stable Ag-titanium-oxo-clusters hydrogel designed for wound healing
Titanium-oxo-clusters (TOCs), due to its precise, tunable structure and rich properties, have been widely used in many fields. However, application of TOCs is greatly limited in biomedical area owing to the impact of its own performances, for example, unstable structure, lack of antibacterial and an...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127523000898 |
| _version_ | 1811158452742914048 |
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| author | Wen Luo Bin Hu Hua-Li Zhang Chunyang Li Yupeng Shi Xingchen Li Lin Jin |
| author_facet | Wen Luo Bin Hu Hua-Li Zhang Chunyang Li Yupeng Shi Xingchen Li Lin Jin |
| author_sort | Wen Luo |
| collection | DOAJ |
| description | Titanium-oxo-clusters (TOCs), due to its precise, tunable structure and rich properties, have been widely used in many fields. However, application of TOCs is greatly limited in biomedical area owing to the impact of its own performances, for example, unstable structure, lack of antibacterial and anti-inflammatory properties required as biomedical materials. In this work, we developed a novel stable, excellent antibacterial and anti-inflammatory properties Ag-Titanium-oxo-cluster (Ag-TOC, Ag9Ti4) with active site Ag and salicylic acid by one-step solvothermal method, through introducing silver and salicylic acid. Then, the Ag9Ti4 cluster was introduced into the dopamine-containing hydrogel system, the results in vitro indicated this Ag9Ti4 cluster hydrogel system possesses good antibacterial and photothermal properties. Moreover, the results in vivo indicated the Ag9Ti4 hydrogel system showed better anti-inflammatory and wound healing ability under NIR condition. Combined with its excellent properties, we believed that the construction of antibacterial, photothermal and stable Ag-TOC hydrogel system can provide a new strategy for the expanding biomedical applications of TOCs. |
| first_indexed | 2024-04-10T05:24:56Z |
| format | Article |
| id | doaj.art-8cc2314eea8c4493a2997e0f551d9a48 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-10T05:24:56Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-8cc2314eea8c4493a2997e0f551d9a482023-03-08T04:13:50ZengElsevierMaterials & Design0264-12752023-02-01226111674Antibacterial, photothermal and stable Ag-titanium-oxo-clusters hydrogel designed for wound healingWen Luo0Bin Hu1Hua-Li Zhang2Chunyang Li3Yupeng Shi4Xingchen Li5Lin Jin6International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou Normal University, Zhoukou, ChinaInternational Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou Normal University, Zhoukou, ChinaInternational Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou Normal University, Zhoukou, ChinaInternational Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou Normal University, Zhoukou, ChinaDepartment of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Corresponding authors.Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Corresponding authors.International Joint Research Laboratory for Biomedical Nanomaterials of Henan, Zhoukou Normal University, Zhoukou, China; Corresponding authors.Titanium-oxo-clusters (TOCs), due to its precise, tunable structure and rich properties, have been widely used in many fields. However, application of TOCs is greatly limited in biomedical area owing to the impact of its own performances, for example, unstable structure, lack of antibacterial and anti-inflammatory properties required as biomedical materials. In this work, we developed a novel stable, excellent antibacterial and anti-inflammatory properties Ag-Titanium-oxo-cluster (Ag-TOC, Ag9Ti4) with active site Ag and salicylic acid by one-step solvothermal method, through introducing silver and salicylic acid. Then, the Ag9Ti4 cluster was introduced into the dopamine-containing hydrogel system, the results in vitro indicated this Ag9Ti4 cluster hydrogel system possesses good antibacterial and photothermal properties. Moreover, the results in vivo indicated the Ag9Ti4 hydrogel system showed better anti-inflammatory and wound healing ability under NIR condition. Combined with its excellent properties, we believed that the construction of antibacterial, photothermal and stable Ag-TOC hydrogel system can provide a new strategy for the expanding biomedical applications of TOCs.http://www.sciencedirect.com/science/article/pii/S0264127523000898Ag-Titanium-oxo-clusterAntibacterialPhotothermalStableHydrogelWound healing |
| spellingShingle | Wen Luo Bin Hu Hua-Li Zhang Chunyang Li Yupeng Shi Xingchen Li Lin Jin Antibacterial, photothermal and stable Ag-titanium-oxo-clusters hydrogel designed for wound healing Materials & Design Ag-Titanium-oxo-cluster Antibacterial Photothermal Stable Hydrogel Wound healing |
| title | Antibacterial, photothermal and stable Ag-titanium-oxo-clusters hydrogel designed for wound healing |
| title_full | Antibacterial, photothermal and stable Ag-titanium-oxo-clusters hydrogel designed for wound healing |
| title_fullStr | Antibacterial, photothermal and stable Ag-titanium-oxo-clusters hydrogel designed for wound healing |
| title_full_unstemmed | Antibacterial, photothermal and stable Ag-titanium-oxo-clusters hydrogel designed for wound healing |
| title_short | Antibacterial, photothermal and stable Ag-titanium-oxo-clusters hydrogel designed for wound healing |
| title_sort | antibacterial photothermal and stable ag titanium oxo clusters hydrogel designed for wound healing |
| topic | Ag-Titanium-oxo-cluster Antibacterial Photothermal Stable Hydrogel Wound healing |
| url | http://www.sciencedirect.com/science/article/pii/S0264127523000898 |
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