Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes
Terminal differentiation is an ill-defined, insufficiently characterized, nonproliferation state. Although it has been classically deemed irreversible, it is now clear that at least several terminally differentiated (TD) cell types can be brought back into the cell cycle. We are striving to uncover...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/10/2753 |
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| author | Deborah Pajalunga Marco Crescenzi |
| author_facet | Deborah Pajalunga Marco Crescenzi |
| author_sort | Deborah Pajalunga |
| collection | DOAJ |
| description | Terminal differentiation is an ill-defined, insufficiently characterized, nonproliferation state. Although it has been classically deemed irreversible, it is now clear that at least several terminally differentiated (TD) cell types can be brought back into the cell cycle. We are striving to uncover the molecular bases of terminal differentiation, whose fundamental understanding is a goal in itself. In addition, the field has sought to acquire the ability to make TD cells proliferate. Attaining this end would probe the very molecular mechanisms we are trying to understand. Equally important, it would be invaluable in regenerative medicine, for tissues depending on TD cells and devoid of significant self-repair capabilities. The skeletal muscle has long been used as a model system to investigate the molecular foundations of terminal differentiation. Here, we summarize more than 50 years of studies in this field. |
| first_indexed | 2024-03-10T06:39:39Z |
| format | Article |
| id | doaj.art-8cc4d8e62e434462a05dbffef65c6a70 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T06:39:39Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8cc4d8e62e434462a05dbffef65c6a702023-11-22T17:48:36ZengMDPI AGCells2073-44092021-10-011010275310.3390/cells10102753Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle MyotubesDeborah Pajalunga0Marco Crescenzi1Department of Oncology and Molecular Medicine, Italian National Institute of Health, 00161 Rome, ItalyCore Facilities, Italian National Institute of Health, 00161 Rome, ItalyTerminal differentiation is an ill-defined, insufficiently characterized, nonproliferation state. Although it has been classically deemed irreversible, it is now clear that at least several terminally differentiated (TD) cell types can be brought back into the cell cycle. We are striving to uncover the molecular bases of terminal differentiation, whose fundamental understanding is a goal in itself. In addition, the field has sought to acquire the ability to make TD cells proliferate. Attaining this end would probe the very molecular mechanisms we are trying to understand. Equally important, it would be invaluable in regenerative medicine, for tissues depending on TD cells and devoid of significant self-repair capabilities. The skeletal muscle has long been used as a model system to investigate the molecular foundations of terminal differentiation. Here, we summarize more than 50 years of studies in this field.https://www.mdpi.com/2073-4409/10/10/2753skeletal muscleterminal differentiationcell cyclepostmitotic stateregenerative medicine |
| spellingShingle | Deborah Pajalunga Marco Crescenzi Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes Cells skeletal muscle terminal differentiation cell cycle postmitotic state regenerative medicine |
| title | Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes |
| title_full | Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes |
| title_fullStr | Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes |
| title_full_unstemmed | Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes |
| title_short | Restoring the Cell Cycle and Proliferation Competence in Terminally Differentiated Skeletal Muscle Myotubes |
| title_sort | restoring the cell cycle and proliferation competence in terminally differentiated skeletal muscle myotubes |
| topic | skeletal muscle terminal differentiation cell cycle postmitotic state regenerative medicine |
| url | https://www.mdpi.com/2073-4409/10/10/2753 |
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