Structural basis of adenylyl cyclase 9 activation
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes, AC9.
Bibliographic Details
| Main Authors: |
Chao Qi,
Pia Lavriha,
Ved Mehta,
Basavraj Khanppnavar,
Inayathulla Mohammed,
Yong Li,
Michalis Lazaratos,
Jonas V. Schaefer,
Birgit Dreier,
Andreas Plückthun,
Ana-Nicoleta Bondar,
Carmen W. Dessauer,
Volodymyr M. Korkhov |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-02-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-28685-y
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