Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology?
SUMMARY: Objectives: Biochemical markers play an important role in the early diagnosis of abdominal pain. This study aimed to investigate the diagnostic value of intestinal type fatty acid binding protein (I-FABP) in patients with abdominal pathology. Methods: This prospective and descriptive study...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2014-09-01
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| Series: | Turkish Journal of Emergency Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452247316300553 |
| _version_ | 1818919178328866816 |
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| author | Ozlem UZUN Suha TURKMEN Umut ERYIGIT Ahmet MENTESE Serdar TURKYILMAZ Suleyman TUREDI Suleyman Caner KARAHAN Abdulkadir GUNDUZ |
| author_facet | Ozlem UZUN Suha TURKMEN Umut ERYIGIT Ahmet MENTESE Serdar TURKYILMAZ Suleyman TUREDI Suleyman Caner KARAHAN Abdulkadir GUNDUZ |
| author_sort | Ozlem UZUN |
| collection | DOAJ |
| description | SUMMARY: Objectives: Biochemical markers play an important role in the early diagnosis of abdominal pain. This study aimed to investigate the diagnostic value of intestinal type fatty acid binding protein (I-FABP) in patients with abdominal pathology. Methods: This prospective and descriptive study was performed at the University Hospital Emergency Department. Serum I-FABP levels of patients presenting with acute abdominal pain were measured at time of admission and were compared with those of healthy individuals. Results: The mean I-FABP level of the 171 patients enrolled in this study was 170.1±543.4 pg/ml, while that of a healthy control group was 61.4±47.4 pg/ml. Although I-FABP levels were higher in the patient group, this difference was not statistically significant (p>0.05). However, I-FABP levels of patients with mesenteric ischemia and intra-abdominal mass were significantly higher than those of healthy individuals (p≤0.05). Conclusions: I-FABP levels that are evaluated at time of admission in patients presenting with abdominal pain to the emergency department are significantly higher in patients with mesenteric ischemia and intra-abdominal mass than are those of healthy individuals. ÖZET: Amaç: Biyokimyasal belirteçler karın ağrısının sebebinin erken tanısında oldukça önemlidir. Bu çalışmada FABP'nin intestinal tipinin (I-FABP) abdominal patolojisi olan hastaların ayırıcı tanısındaki değeri araştırıldı. Gereç ve Yöntem: Mevcut çalışma üniversite hastanesi acil servisinde ileriye yönelik tanımlayıcı olarak çalışma gerçekleştirildi. Karın ağrısı şikayeti ile acil servise başvuran hastalarda başvuru anında alınan serum örneklerinden I-FABP değerlerine bakıldı. Bulgular sağlıklı gönüllülerdeki düzeyler ile karşılaştırıldı. Bulgular: Kayıtlı 171 hastada ölçülen ortalama I-FABP seviyesi 170.1±543.4 pg/ml olarak belirlendi. Sağlıklı gönüllülerde I-FABP seviyesi 61.4±47.4 pg/ml olarak bulundu. Hasta grubunun I-FABP seviyeleri sağlıklı gönüllülere göre yüksek olarak bulunmuşsa da, aradaki fark istatistiksel olarak anlamlı değildi (p>0.05). Başvuru anında ölçülen I-FABP seviyeleri sağlıklı gönüllülerle kıyaslandığında akut mezenter iskemide (AMI) ve karıniçi kitle tespit edilen hastalarda istatistiksel olarak anlamlı yüksekti (p≤0.05). Sonuç: Acil servise karın ağrısı şikayeti ile başvuran hastalardan mezenter iskemi ve karıniçi kitle tanısı alan hastalarda başvuru anında ölçülen serum I-FABP değerleri sağlıklı gönüllülere kıyaslandığında anlamlı olarak yüksek bulunmuştur. Key words: Abdominal mass, abdominal pain, I-FABP, mesenteric ischemia, Anahtar sözcükler: Karın ağrısı, batında kitle, I-FABP, mezenter iskemisi |
| first_indexed | 2024-12-20T01:01:43Z |
| format | Article |
| id | doaj.art-8cc9f6f3653a4959a1e17d1fe8756632 |
| institution | Directory Open Access Journal |
| issn | 2452-2473 |
| language | English |
| last_indexed | 2024-12-20T01:01:43Z |
| publishDate | 2014-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Turkish Journal of Emergency Medicine |
| spelling | doaj.art-8cc9f6f3653a4959a1e17d1fe87566322022-12-21T19:58:58ZengWolters Kluwer Medknow PublicationsTurkish Journal of Emergency Medicine2452-24732014-09-0114399103Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology?Ozlem UZUN0Suha TURKMEN1Umut ERYIGIT2Ahmet MENTESE3Serdar TURKYILMAZ4Suleyman TUREDI5Suleyman Caner KARAHAN6Abdulkadir GUNDUZ7Department of Emergency Medicine, Bagcilar Training and Research Hospital, İstanbulDepartment of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, TrabzonDepartment of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, Trabzon; Correspondence: Dr. Umut Eryigit. Karadeniz Teknik Universitesi Tip Fakultesi, Acil Tıp Anabilim Dali, 61080 Trabzon, TurkeyDepartment of Biochemistry, Karadeniz Technical University Faculty of Medicine, TrabzonDepartment of General Surgery, Karadeniz Technical University Faculty of Medicine, TrabzonDepartment of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, TrabzonDepartment of Biochemistry, Ozel Yildizli Guven Hospital, TrabzonDepartment of Emergency Medicine, Karadeniz Technical University Faculty of Medicine, TrabzonSUMMARY: Objectives: Biochemical markers play an important role in the early diagnosis of abdominal pain. This study aimed to investigate the diagnostic value of intestinal type fatty acid binding protein (I-FABP) in patients with abdominal pathology. Methods: This prospective and descriptive study was performed at the University Hospital Emergency Department. Serum I-FABP levels of patients presenting with acute abdominal pain were measured at time of admission and were compared with those of healthy individuals. Results: The mean I-FABP level of the 171 patients enrolled in this study was 170.1±543.4 pg/ml, while that of a healthy control group was 61.4±47.4 pg/ml. Although I-FABP levels were higher in the patient group, this difference was not statistically significant (p>0.05). However, I-FABP levels of patients with mesenteric ischemia and intra-abdominal mass were significantly higher than those of healthy individuals (p≤0.05). Conclusions: I-FABP levels that are evaluated at time of admission in patients presenting with abdominal pain to the emergency department are significantly higher in patients with mesenteric ischemia and intra-abdominal mass than are those of healthy individuals. ÖZET: Amaç: Biyokimyasal belirteçler karın ağrısının sebebinin erken tanısında oldukça önemlidir. Bu çalışmada FABP'nin intestinal tipinin (I-FABP) abdominal patolojisi olan hastaların ayırıcı tanısındaki değeri araştırıldı. Gereç ve Yöntem: Mevcut çalışma üniversite hastanesi acil servisinde ileriye yönelik tanımlayıcı olarak çalışma gerçekleştirildi. Karın ağrısı şikayeti ile acil servise başvuran hastalarda başvuru anında alınan serum örneklerinden I-FABP değerlerine bakıldı. Bulgular sağlıklı gönüllülerdeki düzeyler ile karşılaştırıldı. Bulgular: Kayıtlı 171 hastada ölçülen ortalama I-FABP seviyesi 170.1±543.4 pg/ml olarak belirlendi. Sağlıklı gönüllülerde I-FABP seviyesi 61.4±47.4 pg/ml olarak bulundu. Hasta grubunun I-FABP seviyeleri sağlıklı gönüllülere göre yüksek olarak bulunmuşsa da, aradaki fark istatistiksel olarak anlamlı değildi (p>0.05). Başvuru anında ölçülen I-FABP seviyeleri sağlıklı gönüllülerle kıyaslandığında akut mezenter iskemide (AMI) ve karıniçi kitle tespit edilen hastalarda istatistiksel olarak anlamlı yüksekti (p≤0.05). Sonuç: Acil servise karın ağrısı şikayeti ile başvuran hastalardan mezenter iskemi ve karıniçi kitle tanısı alan hastalarda başvuru anında ölçülen serum I-FABP değerleri sağlıklı gönüllülere kıyaslandığında anlamlı olarak yüksek bulunmuştur. Key words: Abdominal mass, abdominal pain, I-FABP, mesenteric ischemia, Anahtar sözcükler: Karın ağrısı, batında kitle, I-FABP, mezenter iskemisihttp://www.sciencedirect.com/science/article/pii/S2452247316300553 |
| spellingShingle | Ozlem UZUN Suha TURKMEN Umut ERYIGIT Ahmet MENTESE Serdar TURKYILMAZ Suleyman TUREDI Suleyman Caner KARAHAN Abdulkadir GUNDUZ Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology? Turkish Journal of Emergency Medicine |
| title | Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology? |
| title_full | Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology? |
| title_fullStr | Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology? |
| title_full_unstemmed | Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology? |
| title_short | Can Intestinal Fatty Acid Binding Protein (I-FABP) Be A Marker in the Diagnosis of Abdominal Pathology? |
| title_sort | can intestinal fatty acid binding protein i fabp be a marker in the diagnosis of abdominal pathology |
| url | http://www.sciencedirect.com/science/article/pii/S2452247316300553 |
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