Preclinical research in paclitaxel-induced neuropathic pain: a systematic review
IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a common consequence of cancer treatment and pain is a frequent complaint of the patients. Paclitaxel, a cytostatic drug, generates a well-described peripheral nerve injury and neuroinflammation, which may be experimentally mimicked in...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1264668/full |
| _version_ | 1797387810358951936 |
|---|---|
| author | Carolina Bacalhau José Tiago Costa-Pereira José Tiago Costa-Pereira José Tiago Costa-Pereira Isaura Tavares Isaura Tavares |
| author_facet | Carolina Bacalhau José Tiago Costa-Pereira José Tiago Costa-Pereira José Tiago Costa-Pereira Isaura Tavares Isaura Tavares |
| author_sort | Carolina Bacalhau |
| collection | DOAJ |
| description | IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a common consequence of cancer treatment and pain is a frequent complaint of the patients. Paclitaxel, a cytostatic drug, generates a well-described peripheral nerve injury and neuroinflammation, which may be experimentally mimicked in animal models. We conducted a systematic review analyzing the experimental design, reporting and mechanisms underlying paclitaxel-induced neuropathy in the included studies to establish the perspectives of translation of the current literature in models of CIPN.MethodsWe elected studies published in Pubmed and Scopus between 1 January 2018 and 3 December 2022.ResultsAccording to a defined mesh of keywords searched, and after applying exclusion and inclusion criteria, 70 original studies were included and analyzed in detail. Most studies used male Sprague-Dawley rats to induce paclitaxel-induced neuropathy, used low doses of paclitaxel, and the analyzed studies mainly focused at 14-28 days of CIPN. Mechanical nociceptive tests were preferred in the behavioral evaluation. The mechanisms under study were mainly neuroinflammation of peripheral nerves. The overall methodological quality was considered moderate, and the risk of bias was unclear.DiscussionDespite the ample preclinical research in paclitaxel-induced neuropathy, this systematic review alerts to some flaws in the experimental design along with limitations in reporting, e.g., lack of representation of both sexes in experimental work and the lack of reporting of the ARRIVE guidelines. This may limit the reproducibility of preclinical studies in CIPN. In addition, the clinical features of CIPN should be considered when designing animal experiments, such as sex and age of the CIPN patients. In this way the experimental studies aiming to establish the mechanisms of CIPN may allow the development of new drugs to treat CIPN and translation in the research of CIPN could be improved. |
| first_indexed | 2024-03-08T22:30:32Z |
| format | Article |
| id | doaj.art-8cca97a3abb5457a8b4a0b89e56457d7 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-08T22:30:32Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-8cca97a3abb5457a8b4a0b89e56457d72023-12-18T04:37:29ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-12-011010.3389/fvets.2023.12646681264668Preclinical research in paclitaxel-induced neuropathic pain: a systematic reviewCarolina Bacalhau0José Tiago Costa-Pereira1José Tiago Costa-Pereira2José Tiago Costa-Pereira3Isaura Tavares4Isaura Tavares5Department of Biomedicine, Unit of Experimental Biology, Faculty of Medicine, University of Porto, Porto, PortugalDepartment of Biomedicine, Unit of Experimental Biology, Faculty of Medicine, University of Porto, Porto, PortugalI3S-Institute of Investigation and Innovation in Health, University of Porto, Porto, PortugalFaculty of Nutrition and Food Sciences, University of Porto, Porto, PortugalDepartment of Biomedicine, Unit of Experimental Biology, Faculty of Medicine, University of Porto, Porto, PortugalI3S-Institute of Investigation and Innovation in Health, University of Porto, Porto, PortugalIntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a common consequence of cancer treatment and pain is a frequent complaint of the patients. Paclitaxel, a cytostatic drug, generates a well-described peripheral nerve injury and neuroinflammation, which may be experimentally mimicked in animal models. We conducted a systematic review analyzing the experimental design, reporting and mechanisms underlying paclitaxel-induced neuropathy in the included studies to establish the perspectives of translation of the current literature in models of CIPN.MethodsWe elected studies published in Pubmed and Scopus between 1 January 2018 and 3 December 2022.ResultsAccording to a defined mesh of keywords searched, and after applying exclusion and inclusion criteria, 70 original studies were included and analyzed in detail. Most studies used male Sprague-Dawley rats to induce paclitaxel-induced neuropathy, used low doses of paclitaxel, and the analyzed studies mainly focused at 14-28 days of CIPN. Mechanical nociceptive tests were preferred in the behavioral evaluation. The mechanisms under study were mainly neuroinflammation of peripheral nerves. The overall methodological quality was considered moderate, and the risk of bias was unclear.DiscussionDespite the ample preclinical research in paclitaxel-induced neuropathy, this systematic review alerts to some flaws in the experimental design along with limitations in reporting, e.g., lack of representation of both sexes in experimental work and the lack of reporting of the ARRIVE guidelines. This may limit the reproducibility of preclinical studies in CIPN. In addition, the clinical features of CIPN should be considered when designing animal experiments, such as sex and age of the CIPN patients. In this way the experimental studies aiming to establish the mechanisms of CIPN may allow the development of new drugs to treat CIPN and translation in the research of CIPN could be improved.https://www.frontiersin.org/articles/10.3389/fvets.2023.1264668/fullchemotherapyneuropathic painanimal modelsreproducibilityclinical translation |
| spellingShingle | Carolina Bacalhau José Tiago Costa-Pereira José Tiago Costa-Pereira José Tiago Costa-Pereira Isaura Tavares Isaura Tavares Preclinical research in paclitaxel-induced neuropathic pain: a systematic review Frontiers in Veterinary Science chemotherapy neuropathic pain animal models reproducibility clinical translation |
| title | Preclinical research in paclitaxel-induced neuropathic pain: a systematic review |
| title_full | Preclinical research in paclitaxel-induced neuropathic pain: a systematic review |
| title_fullStr | Preclinical research in paclitaxel-induced neuropathic pain: a systematic review |
| title_full_unstemmed | Preclinical research in paclitaxel-induced neuropathic pain: a systematic review |
| title_short | Preclinical research in paclitaxel-induced neuropathic pain: a systematic review |
| title_sort | preclinical research in paclitaxel induced neuropathic pain a systematic review |
| topic | chemotherapy neuropathic pain animal models reproducibility clinical translation |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1264668/full |
| work_keys_str_mv | AT carolinabacalhau preclinicalresearchinpaclitaxelinducedneuropathicpainasystematicreview AT josetiagocostapereira preclinicalresearchinpaclitaxelinducedneuropathicpainasystematicreview AT josetiagocostapereira preclinicalresearchinpaclitaxelinducedneuropathicpainasystematicreview AT josetiagocostapereira preclinicalresearchinpaclitaxelinducedneuropathicpainasystematicreview AT isauratavares preclinicalresearchinpaclitaxelinducedneuropathicpainasystematicreview AT isauratavares preclinicalresearchinpaclitaxelinducedneuropathicpainasystematicreview |