Polyamines and α-Carbonic Anhydrases
Natural products represent a straightforward source for molecular structures bearing a vast array of chemical features and potentially useful for biomedical purposes. Recent examples of this type include the discovery of the coumarins and the polyamine natural products as atypical chemotypes for the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/21/12/1726 |
| _version_ | 1818082904807309312 |
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| author | Andrea Scozzafava Claudiu T. Supuran Fabrizio Carta |
| author_facet | Andrea Scozzafava Claudiu T. Supuran Fabrizio Carta |
| author_sort | Andrea Scozzafava |
| collection | DOAJ |
| description | Natural products represent a straightforward source for molecular structures bearing a vast array of chemical features and potentially useful for biomedical purposes. Recent examples of this type include the discovery of the coumarins and the polyamine natural products as atypical chemotypes for the inhibition of the metalloenzymes carbonic anhydrases (CAs; EC 4.2.2.1). CA enzymes are established pharmacological targets for important pathologies, which, among others, include glaucoma, hypoxic tumors, and central nervous system (CNS)-affecting diseases. Moreover, they are expressed in many bacteria, fungi and helminths which are the etiological agents of the majority of infectious diseases. In this context, natural products represent the ideal source of new and selective druggable CA modulators for biomedical purposes. Herein we report the state of the art on polyamines of natural origin as well as of synthetic derivatives as inhibitors of human CAs. |
| first_indexed | 2024-12-10T19:29:31Z |
| format | Article |
| id | doaj.art-8ccb1c504b524150908a16219d9fa655 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T19:29:31Z |
| publishDate | 2016-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8ccb1c504b524150908a16219d9fa6552022-12-22T01:36:18ZengMDPI AGMolecules1420-30492016-12-012112172610.3390/molecules21121726molecules21121726Polyamines and α-Carbonic AnhydrasesAndrea Scozzafava0Claudiu T. Supuran1Fabrizio Carta2Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Rm. 188, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, ItalyNEUROFARBA Department, University of Florence, Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, ItalyNEUROFARBA Department, University of Florence, Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, ItalyNatural products represent a straightforward source for molecular structures bearing a vast array of chemical features and potentially useful for biomedical purposes. Recent examples of this type include the discovery of the coumarins and the polyamine natural products as atypical chemotypes for the inhibition of the metalloenzymes carbonic anhydrases (CAs; EC 4.2.2.1). CA enzymes are established pharmacological targets for important pathologies, which, among others, include glaucoma, hypoxic tumors, and central nervous system (CNS)-affecting diseases. Moreover, they are expressed in many bacteria, fungi and helminths which are the etiological agents of the majority of infectious diseases. In this context, natural products represent the ideal source of new and selective druggable CA modulators for biomedical purposes. Herein we report the state of the art on polyamines of natural origin as well as of synthetic derivatives as inhibitors of human CAs.http://www.mdpi.com/1420-3049/21/12/1726polyaminesspermineCA inhibitors |
| spellingShingle | Andrea Scozzafava Claudiu T. Supuran Fabrizio Carta Polyamines and α-Carbonic Anhydrases Molecules polyamines spermine CA inhibitors |
| title | Polyamines and α-Carbonic Anhydrases |
| title_full | Polyamines and α-Carbonic Anhydrases |
| title_fullStr | Polyamines and α-Carbonic Anhydrases |
| title_full_unstemmed | Polyamines and α-Carbonic Anhydrases |
| title_short | Polyamines and α-Carbonic Anhydrases |
| title_sort | polyamines and α carbonic anhydrases |
| topic | polyamines spermine CA inhibitors |
| url | http://www.mdpi.com/1420-3049/21/12/1726 |
| work_keys_str_mv | AT andreascozzafava polyaminesandacarbonicanhydrases AT claudiutsupuran polyaminesandacarbonicanhydrases AT fabriziocarta polyaminesandacarbonicanhydrases |