Individual differences in schizophrenia
Background Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia. Aims To understand and treat individuals with schizophren...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2017-11-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S205647240000243X/type/journal_article |
| _version_ | 1811157103251816448 |
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| author | Edmund T. Rolls Wenlian Lu Lin Wan Hao Yan Chuanyue Wang Fude Yang Yunlong Tan Lingjiang Li Hao Yu Peter F. Liddle Lena Palaniyappan Dai Zhang Weihua Yue Jianfeng Feng |
| author_facet | Edmund T. Rolls Wenlian Lu Lin Wan Hao Yan Chuanyue Wang Fude Yang Yunlong Tan Lingjiang Li Hao Yu Peter F. Liddle Lena Palaniyappan Dai Zhang Weihua Yue Jianfeng Feng |
| author_sort | Edmund T. Rolls |
| collection | DOAJ |
| description |
Background
Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia.
Aims
To understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how fist-episode patients (FEP) may differ from multiple episode patients (MEP).
Method
These issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks.
Results
The seven Negative Symptoms were correlated with each other and with P2 (conceptual disorganisation), G13 (disturbance of volition), and G7 (motor retardation). The main difference between individuals was in the cluster of seven negative symptoms, which had a continuous unimodal distribution. Medication decreased the PANSS scores for all the symptoms, which were similar in the FEP and MEP groups.
Conclusions
The negative symptoms are a major source of individual differences, and there are potential implications for treatment.
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| first_indexed | 2024-04-10T05:00:26Z |
| format | Article |
| id | doaj.art-8ccd750777004da0b5459f90a8dc5ff4 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T05:00:26Z |
| publishDate | 2017-11-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-8ccd750777004da0b5459f90a8dc5ff42023-03-09T12:28:44ZengCambridge University PressBJPsych Open2056-47242017-11-01326527310.1192/bjpo.bp.117.005058Individual differences in schizophreniaEdmund T. Rolls0Wenlian Lu1Lin Wan2Hao Yan3Chuanyue Wang4Fude Yang5Yunlong Tan6Lingjiang Li7Hao Yu8Peter F. Liddle9Lena Palaniyappan10Dai Zhang11Weihua Yue12Jianfeng Feng13Department of Computer Science, University of Warwick, Coventry, UK; Oxford Centre for Computational Neuroscience, Oxford, UKCentre for Computational Systems Biology, Fudan University, Shanghai, PR ChinaNational Center for Mathematics and Interdisciplinary Sciences, The Key Laboratory of Systems and Control, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, PR ChinaInstitute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR ChinaBeijing Anding Hospital, Capital Medical University, Beijing, PR ChinaBeijing HuiLongGuan Hospital, Peking University, Beijing, PR ChinaBeijing HuiLongGuan Hospital, Peking University, Beijing, PR ChinaInstitute of Mental Health, The Second Xiangya Hospital of Central South University, Changsha, PR ChinaInstitute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR ChinaCentre for Translational Neuroimaging, Institute of Mental Health, Division of Psychiatry & Applied Psychology, University of Nottingham, Nottingham, UK; Sir Peter Mansfield MR Centre, University of Nottingham, Nottingham, UKDepartment of Psychiatry, University of Western Ontario, London, Ontario, Canada; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; Robarts & Lawson Health Research Institutes, London, Ontario, CanadaInstitute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR China; Peking-Tsinghua Joint Center for Life Sciences/PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, ChinaInstitute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR ChinaDepartment of Computer Science, University of Warwick, Coventry, UK Background Whether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia. Aims To understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how fist-episode patients (FEP) may differ from multiple episode patients (MEP). Method These issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks. Results The seven Negative Symptoms were correlated with each other and with P2 (conceptual disorganisation), G13 (disturbance of volition), and G7 (motor retardation). The main difference between individuals was in the cluster of seven negative symptoms, which had a continuous unimodal distribution. Medication decreased the PANSS scores for all the symptoms, which were similar in the FEP and MEP groups. Conclusions The negative symptoms are a major source of individual differences, and there are potential implications for treatment. https://www.cambridge.org/core/product/identifier/S205647240000243X/type/journal_article |
| spellingShingle | Edmund T. Rolls Wenlian Lu Lin Wan Hao Yan Chuanyue Wang Fude Yang Yunlong Tan Lingjiang Li Hao Yu Peter F. Liddle Lena Palaniyappan Dai Zhang Weihua Yue Jianfeng Feng Individual differences in schizophrenia BJPsych Open |
| title | Individual differences in schizophrenia |
| title_full | Individual differences in schizophrenia |
| title_fullStr | Individual differences in schizophrenia |
| title_full_unstemmed | Individual differences in schizophrenia |
| title_short | Individual differences in schizophrenia |
| title_sort | individual differences in schizophrenia |
| url | https://www.cambridge.org/core/product/identifier/S205647240000243X/type/journal_article |
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