Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells.
Exercise decreases adiposity and improves metabolic health; however, the physiological and molecular underpinnings of these phenomena remain unknown. Here, we investigate the effect of endurance training on adipose progenitor lineage commitment. Using mice with genetically labeled adipose progenitor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4807773?pdf=render |
| _version_ | 1818412508522741760 |
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| author | Daniel Zeve Douglas P Millay Jin Seo Jonathan M Graff |
| author_facet | Daniel Zeve Douglas P Millay Jin Seo Jonathan M Graff |
| author_sort | Daniel Zeve |
| collection | DOAJ |
| description | Exercise decreases adiposity and improves metabolic health; however, the physiological and molecular underpinnings of these phenomena remain unknown. Here, we investigate the effect of endurance training on adipose progenitor lineage commitment. Using mice with genetically labeled adipose progenitors, we show that these cells react to exercise by decreasing their proliferation and differentiation potential. Analyses of mouse models that mimic the skeletal muscle adaptation to exercise indicate that muscle, in a non-autonomous manner, regulates adipose progenitor homeostasis, highlighting a role for muscle-derived secreted factors. These findings support a humoral link between skeletal muscle and adipose progenitors and indicate that manipulation of adipose stem cell function may help address obesity and diabetes. |
| first_indexed | 2024-12-14T10:48:25Z |
| format | Article |
| id | doaj.art-8ccd8dea042c433a8cbdc28a974da25d |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T10:48:25Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8ccd8dea042c433a8cbdc28a974da25d2022-12-21T23:05:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01113e015212910.1371/journal.pone.0152129Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells.Daniel ZeveDouglas P MillayJin SeoJonathan M GraffExercise decreases adiposity and improves metabolic health; however, the physiological and molecular underpinnings of these phenomena remain unknown. Here, we investigate the effect of endurance training on adipose progenitor lineage commitment. Using mice with genetically labeled adipose progenitors, we show that these cells react to exercise by decreasing their proliferation and differentiation potential. Analyses of mouse models that mimic the skeletal muscle adaptation to exercise indicate that muscle, in a non-autonomous manner, regulates adipose progenitor homeostasis, highlighting a role for muscle-derived secreted factors. These findings support a humoral link between skeletal muscle and adipose progenitors and indicate that manipulation of adipose stem cell function may help address obesity and diabetes.http://europepmc.org/articles/PMC4807773?pdf=render |
| spellingShingle | Daniel Zeve Douglas P Millay Jin Seo Jonathan M Graff Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells. PLoS ONE |
| title | Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells. |
| title_full | Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells. |
| title_fullStr | Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells. |
| title_full_unstemmed | Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells. |
| title_short | Exercise-Induced Skeletal Muscle Adaptations Alter the Activity of Adipose Progenitor Cells. |
| title_sort | exercise induced skeletal muscle adaptations alter the activity of adipose progenitor cells |
| url | http://europepmc.org/articles/PMC4807773?pdf=render |
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