Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial
Abstract Background Dexmedetomidine has advantages during colonoscopy as it allows the patient to cooperate during the procedure. Few studies examined the dexmedetomidine-remifentanil combination. This study was to evaluate the effects of different doses of the dexmedetomidine-remifentanil combinati...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-09-01
|
| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12871-020-01141-4 |
| _version_ | 1818413111550410752 |
|---|---|
| author | Li Jia Meng Xie Jing Zhang Jingyu Guo Tong Tong Yuying Xing |
| author_facet | Li Jia Meng Xie Jing Zhang Jingyu Guo Tong Tong Yuying Xing |
| author_sort | Li Jia |
| collection | DOAJ |
| description | Abstract Background Dexmedetomidine has advantages during colonoscopy as it allows the patient to cooperate during the procedure. Few studies examined the dexmedetomidine-remifentanil combination. This study was to evaluate the effects of different doses of the dexmedetomidine-remifentanil combination in colonoscopy. Methods This was a prospective trial carried out at the Fourth Hospital of Hebei Medical University between 02/2018 and 10/2018. The patients were randomized: group I (dexmedetomidine 0.2 μg·kg− 1), group II (dexmedetomidine 0.3 μg·kg− 1), and group III (dexmedetomidine 0.4 μg·kg− 1), all combined with remifentanil. The primary outcomes were the patient’s body movements during the procedure and adverse events. Results Compared with at admission (T0), the SBP, HR, and RR at immediately after giving DEX (T1), at the beginning of the examination (T2), 5 min after the beginning of the examination (T3), 10 min after the beginning of the examination (T4), and at the end of the examination (T5) in the three groups were all reduced (all P < 0.05), but all were within the clinically normal range. SpO2 remained > 98% in all patients during the examination. Compared with T0, the BIS values of the three groups were decreased at T1 and T2 (all P < 0.05). There were no significant differences in BIS among the three groups (all P > 0.05). The minimum BIS value in group III was lower than in groups I and II (P < 0.05). The degree of satisfaction with the anesthesia effect was higher in groups II and III that in group I (P < 0.05). No hypotension occurred, seven patients had bradycardia, and four patients had nausea/vomiting. Conclusions Dexmedetomidine 0.3 μg·kg− 1 combined with remifentanil was effective for colonoscopy and had few adverse reactions. Chinese Clinical Trial Registry: ChiCTR2000029105 , Registered 13 January 2020 - Retrospectively registered. |
| first_indexed | 2024-12-14T10:58:01Z |
| format | Article |
| id | doaj.art-8ccdb6726459496a9f74e9db2fafa4cb |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-14T10:58:01Z |
| publishDate | 2020-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-8ccdb6726459496a9f74e9db2fafa4cb2022-12-21T23:04:52ZengBMCBMC Anesthesiology1471-22532020-09-012011710.1186/s12871-020-01141-4Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trialLi Jia0Meng Xie1Jing Zhang2Jingyu Guo3Tong Tong4Yuying Xing5Department of Anesthesiology, Fourth Hospital of Hebei Medical UniversityDepartment of Anesthesiology, Fourth Hospital of Hebei Medical UniversityDepartment of Anesthesiology, Fourth Hospital of Hebei Medical UniversityDepartment of Anesthesiology, Fourth Hospital of Hebei Medical UniversityDepartment of Anesthesiology, Fourth Hospital of Hebei Medical UniversityDepartment of Anesthesiology, Fourth Hospital of Hebei Medical UniversityAbstract Background Dexmedetomidine has advantages during colonoscopy as it allows the patient to cooperate during the procedure. Few studies examined the dexmedetomidine-remifentanil combination. This study was to evaluate the effects of different doses of the dexmedetomidine-remifentanil combination in colonoscopy. Methods This was a prospective trial carried out at the Fourth Hospital of Hebei Medical University between 02/2018 and 10/2018. The patients were randomized: group I (dexmedetomidine 0.2 μg·kg− 1), group II (dexmedetomidine 0.3 μg·kg− 1), and group III (dexmedetomidine 0.4 μg·kg− 1), all combined with remifentanil. The primary outcomes were the patient’s body movements during the procedure and adverse events. Results Compared with at admission (T0), the SBP, HR, and RR at immediately after giving DEX (T1), at the beginning of the examination (T2), 5 min after the beginning of the examination (T3), 10 min after the beginning of the examination (T4), and at the end of the examination (T5) in the three groups were all reduced (all P < 0.05), but all were within the clinically normal range. SpO2 remained > 98% in all patients during the examination. Compared with T0, the BIS values of the three groups were decreased at T1 and T2 (all P < 0.05). There were no significant differences in BIS among the three groups (all P > 0.05). The minimum BIS value in group III was lower than in groups I and II (P < 0.05). The degree of satisfaction with the anesthesia effect was higher in groups II and III that in group I (P < 0.05). No hypotension occurred, seven patients had bradycardia, and four patients had nausea/vomiting. Conclusions Dexmedetomidine 0.3 μg·kg− 1 combined with remifentanil was effective for colonoscopy and had few adverse reactions. Chinese Clinical Trial Registry: ChiCTR2000029105 , Registered 13 January 2020 - Retrospectively registered.http://link.springer.com/article/10.1186/s12871-020-01141-4ColonoscopyDexmedetomidinePiperidinesAnalgesiaConscious sedation |
| spellingShingle | Li Jia Meng Xie Jing Zhang Jingyu Guo Tong Tong Yuying Xing Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial BMC Anesthesiology Colonoscopy Dexmedetomidine Piperidines Analgesia Conscious sedation |
| title | Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial |
| title_full | Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial |
| title_fullStr | Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial |
| title_full_unstemmed | Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial |
| title_short | Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial |
| title_sort | efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy a randomized controlled trial |
| topic | Colonoscopy Dexmedetomidine Piperidines Analgesia Conscious sedation |
| url | http://link.springer.com/article/10.1186/s12871-020-01141-4 |
| work_keys_str_mv | AT lijia efficacyofdifferentdoseofdexmedetomidinecombinedwithremifentanilincolonoscopyarandomizedcontrolledtrial AT mengxie efficacyofdifferentdoseofdexmedetomidinecombinedwithremifentanilincolonoscopyarandomizedcontrolledtrial AT jingzhang efficacyofdifferentdoseofdexmedetomidinecombinedwithremifentanilincolonoscopyarandomizedcontrolledtrial AT jingyuguo efficacyofdifferentdoseofdexmedetomidinecombinedwithremifentanilincolonoscopyarandomizedcontrolledtrial AT tongtong efficacyofdifferentdoseofdexmedetomidinecombinedwithremifentanilincolonoscopyarandomizedcontrolledtrial AT yuyingxing efficacyofdifferentdoseofdexmedetomidinecombinedwithremifentanilincolonoscopyarandomizedcontrolledtrial |