Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells
Hypoxia is a common hallmark of healthy tissues in physiological states or chronically inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly through hypoxia-inducible factor (HIF) signaling. Many studies have shown that hypoxia and HIF signaling play an important...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.967576/full |
| _version_ | 1818084012067913728 |
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| author | Jinwei Zhang Jinwei Zhang Jinwei Zhang Xiaoqian Wu Jideng Ma Jideng Ma Keren Long Keren Long Jing Sun Jing Sun Mingzhou Li Liangpeng Ge Liangpeng Ge Liangpeng Ge |
| author_facet | Jinwei Zhang Jinwei Zhang Jinwei Zhang Xiaoqian Wu Jideng Ma Jideng Ma Keren Long Keren Long Jing Sun Jing Sun Mingzhou Li Liangpeng Ge Liangpeng Ge Liangpeng Ge |
| author_sort | Jinwei Zhang |
| collection | DOAJ |
| description | Hypoxia is a common hallmark of healthy tissues in physiological states or chronically inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly through hypoxia-inducible factor (HIF) signaling. Many studies have shown that hypoxia and HIF signaling play an important regulatory role in development and function of innate immune cells and T cells, but their role in B cell biology is still controversial. B cells experience a complex life cycle (including hematopoietic stem cells, pro-B cells, pre-B cells, immature B cells, mature naïve B cells, activated B cells, plasma cells, and memory B cells), and the partial pressure of oxygen (PO2) in the corresponding developmental niche of stage-specific B cells is highly dynamic, which suggests that hypoxia and HIF signaling may play an indispensable role in B cell biology. Based on the fact that hypoxia niches exist in the B cell life cycle, this review focuses on recent discoveries about how hypoxia and HIF signaling regulate the development, metabolism, and function of B cells, to facilitate a deep understanding of the role of hypoxia in B cell-mediated adaptive immunity and to provide novel strategies for vaccine adjuvant research and the treatment of immunity-related or infectious diseases. |
| first_indexed | 2024-12-10T19:47:07Z |
| format | Article |
| id | doaj.art-8cce3c9da0004e1da6d3ea0209edac34 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T19:47:07Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8cce3c9da0004e1da6d3ea0209edac342022-12-22T01:35:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.967576967576Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cellsJinwei Zhang0Jinwei Zhang1Jinwei Zhang2Xiaoqian Wu3Jideng Ma4Jideng Ma5Keren Long6Keren Long7Jing Sun8Jing Sun9Mingzhou Li10Liangpeng Ge11Liangpeng Ge12Liangpeng Ge13Chongqing Academy of Animal Sciences, Chongqing, ChinaKey Laboratory of Pig Industry Sciences, Ministry of Agriculture, Chongqing, ChinaChongqing Camab Biotech Ltd., Chongqing, ChinaChongqing Academy of Animal Sciences, Chongqing, ChinaChongqing Academy of Animal Sciences, Chongqing, ChinaFarm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, ChinaChongqing Academy of Animal Sciences, Chongqing, ChinaFarm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, ChinaChongqing Academy of Animal Sciences, Chongqing, ChinaKey Laboratory of Pig Industry Sciences, Ministry of Agriculture, Chongqing, ChinaFarm Animal Genetic Resource Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, ChinaChongqing Academy of Animal Sciences, Chongqing, ChinaKey Laboratory of Pig Industry Sciences, Ministry of Agriculture, Chongqing, ChinaChongqing Camab Biotech Ltd., Chongqing, ChinaHypoxia is a common hallmark of healthy tissues in physiological states or chronically inflamed tissues in pathological states. Mammalian cells sense and adapt to hypoxia mainly through hypoxia-inducible factor (HIF) signaling. Many studies have shown that hypoxia and HIF signaling play an important regulatory role in development and function of innate immune cells and T cells, but their role in B cell biology is still controversial. B cells experience a complex life cycle (including hematopoietic stem cells, pro-B cells, pre-B cells, immature B cells, mature naïve B cells, activated B cells, plasma cells, and memory B cells), and the partial pressure of oxygen (PO2) in the corresponding developmental niche of stage-specific B cells is highly dynamic, which suggests that hypoxia and HIF signaling may play an indispensable role in B cell biology. Based on the fact that hypoxia niches exist in the B cell life cycle, this review focuses on recent discoveries about how hypoxia and HIF signaling regulate the development, metabolism, and function of B cells, to facilitate a deep understanding of the role of hypoxia in B cell-mediated adaptive immunity and to provide novel strategies for vaccine adjuvant research and the treatment of immunity-related or infectious diseases.https://www.frontiersin.org/articles/10.3389/fimmu.2022.967576/fullhypoxiahypoxia-inducible factor signalingB cell biologydevelopmentmetabolismfunction |
| spellingShingle | Jinwei Zhang Jinwei Zhang Jinwei Zhang Xiaoqian Wu Jideng Ma Jideng Ma Keren Long Keren Long Jing Sun Jing Sun Mingzhou Li Liangpeng Ge Liangpeng Ge Liangpeng Ge Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells Frontiers in Immunology hypoxia hypoxia-inducible factor signaling B cell biology development metabolism function |
| title | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
| title_full | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
| title_fullStr | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
| title_full_unstemmed | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
| title_short | Hypoxia and hypoxia-inducible factor signals regulate the development, metabolism, and function of B cells |
| title_sort | hypoxia and hypoxia inducible factor signals regulate the development metabolism and function of b cells |
| topic | hypoxia hypoxia-inducible factor signaling B cell biology development metabolism function |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.967576/full |
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