Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease
Introduction: The identification and validation of a non-invasive prognostic marker for early detection of diabetic kidney disease (DKD) can lead to substantial improvement in therapeutic decision-making. Objectives: The main objective of this study is to assess the potential role of the arachidonic...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123222001096 |
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| author | Pamela Houeiss Rachel Njeim Hani Tamim Ahmed F. Hamdy Tanya S. Azar William S. Azar Mohamed Noureldein Youssef H. Zeidan Awad Rashid Sami T. Azar Assaad A. Eid |
| author_facet | Pamela Houeiss Rachel Njeim Hani Tamim Ahmed F. Hamdy Tanya S. Azar William S. Azar Mohamed Noureldein Youssef H. Zeidan Awad Rashid Sami T. Azar Assaad A. Eid |
| author_sort | Pamela Houeiss |
| collection | DOAJ |
| description | Introduction: The identification and validation of a non-invasive prognostic marker for early detection of diabetic kidney disease (DKD) can lead to substantial improvement in therapeutic decision-making. Objectives: The main objective of this study is to assess the potential role of the arachidonic acid (AA) metabolite 20-hydroxyeicosatetraenoic (20-HETE) in predicting the incidence and progression of DKD. Methods: Healthy patients and patients with diabetes were recruited from the Hamad General Hospital in Qatar, and urinary 20-HETE levels were measured. Data analysis was done using the Statistical Package for Social Sciences (SPSS). Results: Our results show that urinary 20-HETE-to-creatinine (20-HETE/Cr) ratios were significantly elevated in patients with DKD when compared to patients with diabetes who did not exhibit clinical signs of kidney injury (p < 0.001). This correlation was preserved in the multivariate linear regression accounting for age, diabetes, family history of kidney disease, hypertension, dyslipidemia, stroke and metabolic syndrome. Urinary 20-HETE/Cr ratios were also positively correlated with the severity of kidney injury as indicated by albuminuria levels (p < 0.001). A urinary 20-HETE/Cr ratio of 4.6 pmol/mg discriminated between the presence and absence of kidney disease with a sensitivity of 82.2 % and a specificity of 67.1%. More importantly, a 10-unit increase in urinary 20-HETE/Cr ratio was tied to a 10-fold increase in the risk of developing DKD, suggesting a 20-HETE prognostic efficiency. Conclusion: Taken together, our results suggest that urinary 20-HETE levels can potentially be used as non-invasive diagnostic and prognostic markers for DKD. |
| first_indexed | 2024-04-10T18:54:50Z |
| format | Article |
| id | doaj.art-8ccea6fb8e1842138600c7ef337f8083 |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-04-10T18:54:50Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-8ccea6fb8e1842138600c7ef337f80832023-02-01T04:25:40ZengElsevierJournal of Advanced Research2090-12322023-02-0144109117Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney diseasePamela Houeiss0Rachel Njeim1Hani Tamim2Ahmed F. Hamdy3Tanya S. Azar4William S. Azar5Mohamed Noureldein6Youssef H. Zeidan7Awad Rashid8Sami T. Azar9Assaad A. Eid10Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Lebanon; AUB Diabetes Program, Faculty of Medicine, American University of Beirut, LebanonDepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Lebanon; AUB Diabetes Program, Faculty of Medicine, American University of Beirut, LebanonDepartment of Internal Medicine, Faculty of Medicine, American University of Beirut, LebanonDepartment of Nephrology, Hamad Medical Corporation, Doha, QatarDepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Lebanon; AUB Diabetes Program, Faculty of Medicine, American University of Beirut, LebanonDepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Lebanon; AUB Diabetes Program, Faculty of Medicine, American University of Beirut, Lebanon; Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC, USADepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Lebanon; AUB Diabetes Program, Faculty of Medicine, American University of Beirut, LebanonDepartment of Radiation Oncology, Faculty of Medicine, American University of Beirut, LebanonDepartment of Nephrology, Hamad Medical Corporation, Doha, QatarAUB Diabetes Program, Faculty of Medicine, American University of Beirut, Lebanon; Department of Internal Medicine, Faculty of Medicine, American University of Beirut, LebanonDepartment of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Lebanon; AUB Diabetes Program, Faculty of Medicine, American University of Beirut, Lebanon; Corresponding author at: American University of Beirut, Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine and Medical Center, Bliss Street, 11-0236, Riad El- Solh 1107-2020, Lebanon.Introduction: The identification and validation of a non-invasive prognostic marker for early detection of diabetic kidney disease (DKD) can lead to substantial improvement in therapeutic decision-making. Objectives: The main objective of this study is to assess the potential role of the arachidonic acid (AA) metabolite 20-hydroxyeicosatetraenoic (20-HETE) in predicting the incidence and progression of DKD. Methods: Healthy patients and patients with diabetes were recruited from the Hamad General Hospital in Qatar, and urinary 20-HETE levels were measured. Data analysis was done using the Statistical Package for Social Sciences (SPSS). Results: Our results show that urinary 20-HETE-to-creatinine (20-HETE/Cr) ratios were significantly elevated in patients with DKD when compared to patients with diabetes who did not exhibit clinical signs of kidney injury (p < 0.001). This correlation was preserved in the multivariate linear regression accounting for age, diabetes, family history of kidney disease, hypertension, dyslipidemia, stroke and metabolic syndrome. Urinary 20-HETE/Cr ratios were also positively correlated with the severity of kidney injury as indicated by albuminuria levels (p < 0.001). A urinary 20-HETE/Cr ratio of 4.6 pmol/mg discriminated between the presence and absence of kidney disease with a sensitivity of 82.2 % and a specificity of 67.1%. More importantly, a 10-unit increase in urinary 20-HETE/Cr ratio was tied to a 10-fold increase in the risk of developing DKD, suggesting a 20-HETE prognostic efficiency. Conclusion: Taken together, our results suggest that urinary 20-HETE levels can potentially be used as non-invasive diagnostic and prognostic markers for DKD.http://www.sciencedirect.com/science/article/pii/S2090123222001096DiabetesBiomarkersDiabetic Kidney DiseasesMicrovascular ComplicationsMacrovascular Complications20-HETE |
| spellingShingle | Pamela Houeiss Rachel Njeim Hani Tamim Ahmed F. Hamdy Tanya S. Azar William S. Azar Mohamed Noureldein Youssef H. Zeidan Awad Rashid Sami T. Azar Assaad A. Eid Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease Journal of Advanced Research Diabetes Biomarkers Diabetic Kidney Diseases Microvascular Complications Macrovascular Complications 20-HETE |
| title | Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease |
| title_full | Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease |
| title_fullStr | Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease |
| title_full_unstemmed | Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease |
| title_short | Urinary 20-HETE: A prospective Non-Invasive prognostic and diagnostic marker for diabetic kidney disease |
| title_sort | urinary 20 hete a prospective non invasive prognostic and diagnostic marker for diabetic kidney disease |
| topic | Diabetes Biomarkers Diabetic Kidney Diseases Microvascular Complications Macrovascular Complications 20-HETE |
| url | http://www.sciencedirect.com/science/article/pii/S2090123222001096 |
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