Macrophage polarization in inflammatory bowel disease
Abstract The growing prevalence of inflammatory bowel disease (IBD) has encouraged research efforts, which have contributed to gradual improvements in our understanding of IBD diagnosis and therapeutic approaches. The pathogenesis of IBD has not been fully elucidated; however, the combined actions o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01386-9 |
| _version_ | 1797376850301812736 |
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| author | Kun Zhang Jing Guo Wenlong Yan Lingfen Xu |
| author_facet | Kun Zhang Jing Guo Wenlong Yan Lingfen Xu |
| author_sort | Kun Zhang |
| collection | DOAJ |
| description | Abstract The growing prevalence of inflammatory bowel disease (IBD) has encouraged research efforts, which have contributed to gradual improvements in our understanding of IBD diagnosis and therapeutic approaches. The pathogenesis of IBD has not been fully elucidated; however, the combined actions of environmental, genetic, immune factors, and microbial organisms are believed to cause IBD. In the innate immune system, macrophages play important roles in maintaining intestinal health and in the development of IBD. Macrophages can be polarized from M0 into several phenotypes, among which M1 and M2 play critical roles in IBD development and the repair of intestinal homeostasis and damage. Certain macrophage-related IBD studies already exist; however, the functions of each phenotype have not been fully elucidated. As technology develops, understanding the link between macrophages and IBD has increased, including the growing knowledge of the developmental origins of intestinal macrophages and their performance of comprehensive functions. This review describes macrophage polarization in IBD from the perspectives of macrophage development and polarization, macrophage changes in homeostasis and IBD, metabolic changes, and the mechanisms of macrophage polarization in IBD. The discussion of these topics provides new insights into immunotherapy strategies for IBD. Video Abstract |
| first_indexed | 2024-03-08T19:45:31Z |
| format | Article |
| id | doaj.art-8ccf06c756d14d44801f2d1032ce9890 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-03-08T19:45:31Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-8ccf06c756d14d44801f2d1032ce98902023-12-24T12:24:45ZengBMCCell Communication and Signaling1478-811X2023-12-0121111410.1186/s12964-023-01386-9Macrophage polarization in inflammatory bowel diseaseKun Zhang0Jing Guo1Wenlong Yan2Lingfen Xu3Department of Pediatrics, Shengjing Hospital of China Medical UniversityDepartment of Pediatrics, Shengjing Hospital of China Medical UniversityDepartment of Pediatrics, Shengjing Hospital of China Medical UniversityDepartment of Pediatrics, Shengjing Hospital of China Medical UniversityAbstract The growing prevalence of inflammatory bowel disease (IBD) has encouraged research efforts, which have contributed to gradual improvements in our understanding of IBD diagnosis and therapeutic approaches. The pathogenesis of IBD has not been fully elucidated; however, the combined actions of environmental, genetic, immune factors, and microbial organisms are believed to cause IBD. In the innate immune system, macrophages play important roles in maintaining intestinal health and in the development of IBD. Macrophages can be polarized from M0 into several phenotypes, among which M1 and M2 play critical roles in IBD development and the repair of intestinal homeostasis and damage. Certain macrophage-related IBD studies already exist; however, the functions of each phenotype have not been fully elucidated. As technology develops, understanding the link between macrophages and IBD has increased, including the growing knowledge of the developmental origins of intestinal macrophages and their performance of comprehensive functions. This review describes macrophage polarization in IBD from the perspectives of macrophage development and polarization, macrophage changes in homeostasis and IBD, metabolic changes, and the mechanisms of macrophage polarization in IBD. The discussion of these topics provides new insights into immunotherapy strategies for IBD. Video Abstracthttps://doi.org/10.1186/s12964-023-01386-9MacrophagePolarizationInflammatory bowel diseaseSignaling pathwayImmunotherapy |
| spellingShingle | Kun Zhang Jing Guo Wenlong Yan Lingfen Xu Macrophage polarization in inflammatory bowel disease Cell Communication and Signaling Macrophage Polarization Inflammatory bowel disease Signaling pathway Immunotherapy |
| title | Macrophage polarization in inflammatory bowel disease |
| title_full | Macrophage polarization in inflammatory bowel disease |
| title_fullStr | Macrophage polarization in inflammatory bowel disease |
| title_full_unstemmed | Macrophage polarization in inflammatory bowel disease |
| title_short | Macrophage polarization in inflammatory bowel disease |
| title_sort | macrophage polarization in inflammatory bowel disease |
| topic | Macrophage Polarization Inflammatory bowel disease Signaling pathway Immunotherapy |
| url | https://doi.org/10.1186/s12964-023-01386-9 |
| work_keys_str_mv | AT kunzhang macrophagepolarizationininflammatoryboweldisease AT jingguo macrophagepolarizationininflammatoryboweldisease AT wenlongyan macrophagepolarizationininflammatoryboweldisease AT lingfenxu macrophagepolarizationininflammatoryboweldisease |