Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in Iran
Abstract Introduction COVID-19 clinical course, effective therapeutic regimen, and poor prognosis risk factors in pediatric cases are still under investigation and no approved vaccinehas been introduced for them. Methods This cross-sectional study evaluated different aspect of COVID-19 infection in...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-021-03030-2 |
| _version_ | 1818384005531172864 |
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| author | Sedigheh Madani Sarvenaz Shahin Moein Yoosefi Naser Ahmadi Erfan Ghasemi Sogol Koolaji Esmaeil Mohammadi Sahar Mohammadi Fateh Amirali Hajebi Ameneh Kazemi Erfan Pakatchian Negar Rezaei Hamidreza Jamshidi Bagher Larijani Farshad Farzadfar |
| author_facet | Sedigheh Madani Sarvenaz Shahin Moein Yoosefi Naser Ahmadi Erfan Ghasemi Sogol Koolaji Esmaeil Mohammadi Sahar Mohammadi Fateh Amirali Hajebi Ameneh Kazemi Erfan Pakatchian Negar Rezaei Hamidreza Jamshidi Bagher Larijani Farshad Farzadfar |
| author_sort | Sedigheh Madani |
| collection | DOAJ |
| description | Abstract Introduction COVID-19 clinical course, effective therapeutic regimen, and poor prognosis risk factors in pediatric cases are still under investigation and no approved vaccinehas been introduced for them. Methods This cross-sectional study evaluated different aspect of COVID-19 infection in hospitalized COVID-19 positive children (≺18 years oldwith laboratory confirmed COVID-19 infection, using the national COVID-19 registry for all admitted COVID-19 positive cases from February 19 until November 13,2020, in Iran. Results We evaluated 6610 hospitalized children. Fifty-four percent (3268) were male and one third of them were infants younger than 1 year. Mortality rate in total hospitalized children was 5.3% and in children with underlying co-morbidities (14.4%) was significantly higher (OR: 3.6 [2.7-4.7]). Chronic kidney disease (OR: 3.42 [1.75-6.67]), Cardiovascular diseases (OR: 3.2 [2.09-5.11]), chronic pulmonary diseases (OR: 3.21 [1.59-6.47]), and diabetes mellitus (OR: 2.5 [1.38-4.55]), resulted in higher mortality rates in hospitalized COVID-19 children. Fever (41%), cough (36%), and dyspnea (27%) were the most frequent symptoms in hospitalized children and dyspnea was associated with near three times higher mortality rate among children with COVID-19 infection (OR: 2.65 [2.13-3.29]). Conclusion Iran has relatively high COVID-19 mortality in hospitalized children. Pediatricians should consider children presenting with dyspnea, infants≺ 1 year and children with underlying co-morbidities, as high-risk groups for hospitalization, ICU admission, and death. |
| first_indexed | 2024-12-14T03:15:23Z |
| format | Article |
| id | doaj.art-8cd028d956234aa393b5ae938939917f |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-14T03:15:23Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-8cd028d956234aa393b5ae938939917f2022-12-21T23:19:10ZengBMCBMC Pediatrics1471-24312021-12-012111910.1186/s12887-021-03030-2Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in IranSedigheh Madani0Sarvenaz Shahin1Moein Yoosefi2Naser Ahmadi3Erfan Ghasemi4Sogol Koolaji5Esmaeil Mohammadi6Sahar Mohammadi Fateh7Amirali Hajebi8Ameneh Kazemi9Erfan Pakatchian10Negar Rezaei11Hamidreza Jamshidi12Bagher Larijani13Farshad Farzadfar14Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesResearch Institute for Endocrine Sciences, School of Medicine, Department of Pharmacology, Shahid Beheshti University of Medical SciencesEndocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesNon-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical SciencesAbstract Introduction COVID-19 clinical course, effective therapeutic regimen, and poor prognosis risk factors in pediatric cases are still under investigation and no approved vaccinehas been introduced for them. Methods This cross-sectional study evaluated different aspect of COVID-19 infection in hospitalized COVID-19 positive children (≺18 years oldwith laboratory confirmed COVID-19 infection, using the national COVID-19 registry for all admitted COVID-19 positive cases from February 19 until November 13,2020, in Iran. Results We evaluated 6610 hospitalized children. Fifty-four percent (3268) were male and one third of them were infants younger than 1 year. Mortality rate in total hospitalized children was 5.3% and in children with underlying co-morbidities (14.4%) was significantly higher (OR: 3.6 [2.7-4.7]). Chronic kidney disease (OR: 3.42 [1.75-6.67]), Cardiovascular diseases (OR: 3.2 [2.09-5.11]), chronic pulmonary diseases (OR: 3.21 [1.59-6.47]), and diabetes mellitus (OR: 2.5 [1.38-4.55]), resulted in higher mortality rates in hospitalized COVID-19 children. Fever (41%), cough (36%), and dyspnea (27%) were the most frequent symptoms in hospitalized children and dyspnea was associated with near three times higher mortality rate among children with COVID-19 infection (OR: 2.65 [2.13-3.29]). Conclusion Iran has relatively high COVID-19 mortality in hospitalized children. Pediatricians should consider children presenting with dyspnea, infants≺ 1 year and children with underlying co-morbidities, as high-risk groups for hospitalization, ICU admission, and death.https://doi.org/10.1186/s12887-021-03030-2COVID-19ChildrenIranEpidemiologyMortality |
| spellingShingle | Sedigheh Madani Sarvenaz Shahin Moein Yoosefi Naser Ahmadi Erfan Ghasemi Sogol Koolaji Esmaeil Mohammadi Sahar Mohammadi Fateh Amirali Hajebi Ameneh Kazemi Erfan Pakatchian Negar Rezaei Hamidreza Jamshidi Bagher Larijani Farshad Farzadfar Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in Iran BMC Pediatrics COVID-19 Children Iran Epidemiology Mortality |
| title | Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in Iran |
| title_full | Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in Iran |
| title_fullStr | Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in Iran |
| title_full_unstemmed | Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in Iran |
| title_short | Red flags of poor prognosis in pediatric cases of COVID-19: the first 6610 hospitalized children in Iran |
| title_sort | red flags of poor prognosis in pediatric cases of covid 19 the first 6610 hospitalized children in iran |
| topic | COVID-19 Children Iran Epidemiology Mortality |
| url | https://doi.org/10.1186/s12887-021-03030-2 |
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