In vitro Activities of Nemonoxacin and Other Antimicrobial Agents Against Human Mycoplasma and Ureaplasmas Isolates and Their Defined Resistance Mechanisms
Nemonoxacin, a newly developed non-fluorinated quinolone (NFQ), selectively inhibits bacterial DNA topoisomerase activity. However, its activities against Mycoplasmas have rarely been studied to date. Herein, the activities of nemonoxacin were evaluated against clinical isolates of 50 Mycoplasma pne...
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.01890/full |
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| author | Na Wang Na Wang Wancheng Liu Yunheng Zhou Yang Liu Yang Liu |
| author_facet | Na Wang Na Wang Wancheng Liu Yunheng Zhou Yang Liu Yang Liu |
| author_sort | Na Wang |
| collection | DOAJ |
| description | Nemonoxacin, a newly developed non-fluorinated quinolone (NFQ), selectively inhibits bacterial DNA topoisomerase activity. However, its activities against Mycoplasmas have rarely been studied to date. Herein, the activities of nemonoxacin were evaluated against clinical isolates of 50 Mycoplasma pneumoniae, 20 Mycoplasma hominis, and 77 Ureaplasma spp., and they were compared to fluoroquinolones, tetracyclines, and macrolides. Nemonoxacin MICs (μg/ml) ranged from 0.03 to 0.25 for M. pneumoniae, 0.25 to 8 for M. hominis, and 0.06 to >16 for Ureaplasma spp., and all of the ranges are similar to those of fluoroquinolones. The activity of nemonoxacin against Mycoplasmas was not affected by resistance to macrolides in the strains tested, but it seems to have the same resistant mechanism as fluoroquinolones. In addition, minimum bactericidal concentrations (MBC) of nemonoxacin to M. pneumoniae were within two dilutions of the MIC values, indicating a bactericidal effect on M. pneumoniae. Nemonoxacin merits further study for treating infections caused by these organisms. |
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| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-20T10:18:49Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj.art-8cd0c1b9bb864af1af2666c52fb9b7382022-12-21T19:43:59ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-08-011010.3389/fmicb.2019.01890471211In vitro Activities of Nemonoxacin and Other Antimicrobial Agents Against Human Mycoplasma and Ureaplasmas Isolates and Their Defined Resistance MechanismsNa Wang0Na Wang1Wancheng Liu2Yunheng Zhou3Yang Liu4Yang Liu5Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, ChinaKey Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Fudan University, Shanghai, ChinaSuzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, ChinaDepartment of Clinical Laboratory, Shanghai Corps Hospital, Chinese People’s Armed Police Forces, Shanghai, ChinaInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, ChinaKey Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Fudan University, Shanghai, ChinaNemonoxacin, a newly developed non-fluorinated quinolone (NFQ), selectively inhibits bacterial DNA topoisomerase activity. However, its activities against Mycoplasmas have rarely been studied to date. Herein, the activities of nemonoxacin were evaluated against clinical isolates of 50 Mycoplasma pneumoniae, 20 Mycoplasma hominis, and 77 Ureaplasma spp., and they were compared to fluoroquinolones, tetracyclines, and macrolides. Nemonoxacin MICs (μg/ml) ranged from 0.03 to 0.25 for M. pneumoniae, 0.25 to 8 for M. hominis, and 0.06 to >16 for Ureaplasma spp., and all of the ranges are similar to those of fluoroquinolones. The activity of nemonoxacin against Mycoplasmas was not affected by resistance to macrolides in the strains tested, but it seems to have the same resistant mechanism as fluoroquinolones. In addition, minimum bactericidal concentrations (MBC) of nemonoxacin to M. pneumoniae were within two dilutions of the MIC values, indicating a bactericidal effect on M. pneumoniae. Nemonoxacin merits further study for treating infections caused by these organisms.https://www.frontiersin.org/article/10.3389/fmicb.2019.01890/fullnemonoxacinMycoplasmaUreaplasmaantimicrobial resistanceMICs |
| spellingShingle | Na Wang Na Wang Wancheng Liu Yunheng Zhou Yang Liu Yang Liu In vitro Activities of Nemonoxacin and Other Antimicrobial Agents Against Human Mycoplasma and Ureaplasmas Isolates and Their Defined Resistance Mechanisms Frontiers in Microbiology nemonoxacin Mycoplasma Ureaplasma antimicrobial resistance MICs |
| title | In vitro Activities of Nemonoxacin and Other Antimicrobial Agents Against Human Mycoplasma and Ureaplasmas Isolates and Their Defined Resistance Mechanisms |
| title_full | In vitro Activities of Nemonoxacin and Other Antimicrobial Agents Against Human Mycoplasma and Ureaplasmas Isolates and Their Defined Resistance Mechanisms |
| title_fullStr | In vitro Activities of Nemonoxacin and Other Antimicrobial Agents Against Human Mycoplasma and Ureaplasmas Isolates and Their Defined Resistance Mechanisms |
| title_full_unstemmed | In vitro Activities of Nemonoxacin and Other Antimicrobial Agents Against Human Mycoplasma and Ureaplasmas Isolates and Their Defined Resistance Mechanisms |
| title_short | In vitro Activities of Nemonoxacin and Other Antimicrobial Agents Against Human Mycoplasma and Ureaplasmas Isolates and Their Defined Resistance Mechanisms |
| title_sort | in vitro activities of nemonoxacin and other antimicrobial agents against human mycoplasma and ureaplasmas isolates and their defined resistance mechanisms |
| topic | nemonoxacin Mycoplasma Ureaplasma antimicrobial resistance MICs |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.01890/full |
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