Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19
SARS-CoV-2 uses the ACE2 receptor and the cellular protease TMPRSS2 for entry into target cells. The present study aimed to establish if the TMPRSS2 polymorphisms are associated with COVID-19 disease. The study included 609 patients with COVID-19 confirmed by RT-PCR test and 291 individuals negative...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/9/1976 |
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| author | Rosalinda Posadas-Sánchez José Manuel Fragoso Fausto Sánchez-Muñoz Gustavo Rojas-Velasco Julian Ramírez-Bello Alberto López-Reyes Laura E. Martínez-Gómez Carlos Sierra-Fernández Tatiana Rodríguez-Reyna Nora Elemi Regino-Zamarripa Gustavo Ramírez-Martínez Joaquín Zuñiga-Ramos Gilberto Vargas-Alarcón |
| author_facet | Rosalinda Posadas-Sánchez José Manuel Fragoso Fausto Sánchez-Muñoz Gustavo Rojas-Velasco Julian Ramírez-Bello Alberto López-Reyes Laura E. Martínez-Gómez Carlos Sierra-Fernández Tatiana Rodríguez-Reyna Nora Elemi Regino-Zamarripa Gustavo Ramírez-Martínez Joaquín Zuñiga-Ramos Gilberto Vargas-Alarcón |
| author_sort | Rosalinda Posadas-Sánchez |
| collection | DOAJ |
| description | SARS-CoV-2 uses the ACE2 receptor and the cellular protease TMPRSS2 for entry into target cells. The present study aimed to establish if the TMPRSS2 polymorphisms are associated with COVID-19 disease. The study included 609 patients with COVID-19 confirmed by RT-PCR test and 291 individuals negative for the SARS-CoV-2 infection confirmed by RT-PCR test and without antibodies anti-SARS-CoV-2. Four TMPRSS2 polymorphisms (rs12329760, rs2298659, rs456298, and rs462574) were determined using the 5′exonuclease TaqMan assays. Under different inheritance models, the rs2298659 (<i>p</i><sub>codominant2</sub> = 0.018, <i>p</i><sub>recessive</sub> = 0.006, <i>p</i><sub>additive</sub> = 0.019), rs456298 (<i>p</i><sub>codominant1</sub> = 0.014, <i>p</i><sub>codominant2</sub> = 0.004; <i>p</i><sub>dominant</sub> = 0.009, <i>p</i><sub>recessive</sub> = 0.004, <i>p</i><sub>additive</sub> = 0.0009), and rs462574 (<i>p</i><sub>codominant1</sub> = 0.017, <i>p</i><sub>codominant2</sub> = 0.004, <i>p</i><sub>dominant</sub> = 0.041, <i>p</i><sub>recessive</sub> = 0.002, <i>p</i><sub>additive</sub> = 0.003) polymorphisms were associated with high risk of developing COVID-19. Two risks (<i>ATGC</i> and <i>GAAC</i>) and two protectives (<i>GAGC</i> and <i>GAGT</i>) haplotypes were detected. High levels of lactic acid dehydrogenase (LDH) were observed in patients with the rs462574<i>AA</i> and rs456298<i>TT</i> genotypes (<i>p</i> = 0.005 and <i>p</i> = 0.020, respectively), whereas, high heart rate was present in patients with the rs462574<i>AA</i> genotype (<i>p</i> = 0.028). Our data suggest that the rs2298659, rs456298, and rs462574 polymorphisms independently and as haplotypes are associated with the risk of COVID-19. The rs456298 and rs462574 genotypes are related to high levels of LDH and heart rate. |
| first_indexed | 2024-03-09T22:13:30Z |
| format | Article |
| id | doaj.art-8cd116bcdb7c4f28aa976ef645fae09f |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T22:13:30Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-8cd116bcdb7c4f28aa976ef645fae09f2023-11-23T19:27:25ZengMDPI AGViruses1999-49152022-09-01149197610.3390/v14091976Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19Rosalinda Posadas-Sánchez0José Manuel Fragoso1Fausto Sánchez-Muñoz2Gustavo Rojas-Velasco3Julian Ramírez-Bello4Alberto López-Reyes5Laura E. Martínez-Gómez6Carlos Sierra-Fernández7Tatiana Rodríguez-Reyna8Nora Elemi Regino-Zamarripa9Gustavo Ramírez-Martínez10Joaquín Zuñiga-Ramos11Gilberto Vargas-Alarcón12Department of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Sección XVI, Tlalpan, Mexico City 14080, MexicoDepartament of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoIntensive Care Unit, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment of Endocrinology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoLaboratorio de Gerociencias, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Mexico City 14080, MexicoLaboratorio de Gerociencias, Instituto Nacional de Rehabilitación “Luis Guillermo Ibarra Ibarra”, Mexico City 14080, MexicoDirección de Enseñanza, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City 14080, MexicoDepartment or Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City 14080, MexicoTecnologico de Monterrey, Monterrey 64849, MexicoImmunology and Genetics Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoTecnologico de Monterrey, Monterrey 64849, MexicoDepartment of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Sección XVI, Tlalpan, Mexico City 14080, MexicoSARS-CoV-2 uses the ACE2 receptor and the cellular protease TMPRSS2 for entry into target cells. The present study aimed to establish if the TMPRSS2 polymorphisms are associated with COVID-19 disease. The study included 609 patients with COVID-19 confirmed by RT-PCR test and 291 individuals negative for the SARS-CoV-2 infection confirmed by RT-PCR test and without antibodies anti-SARS-CoV-2. Four TMPRSS2 polymorphisms (rs12329760, rs2298659, rs456298, and rs462574) were determined using the 5′exonuclease TaqMan assays. Under different inheritance models, the rs2298659 (<i>p</i><sub>codominant2</sub> = 0.018, <i>p</i><sub>recessive</sub> = 0.006, <i>p</i><sub>additive</sub> = 0.019), rs456298 (<i>p</i><sub>codominant1</sub> = 0.014, <i>p</i><sub>codominant2</sub> = 0.004; <i>p</i><sub>dominant</sub> = 0.009, <i>p</i><sub>recessive</sub> = 0.004, <i>p</i><sub>additive</sub> = 0.0009), and rs462574 (<i>p</i><sub>codominant1</sub> = 0.017, <i>p</i><sub>codominant2</sub> = 0.004, <i>p</i><sub>dominant</sub> = 0.041, <i>p</i><sub>recessive</sub> = 0.002, <i>p</i><sub>additive</sub> = 0.003) polymorphisms were associated with high risk of developing COVID-19. Two risks (<i>ATGC</i> and <i>GAAC</i>) and two protectives (<i>GAGC</i> and <i>GAGT</i>) haplotypes were detected. High levels of lactic acid dehydrogenase (LDH) were observed in patients with the rs462574<i>AA</i> and rs456298<i>TT</i> genotypes (<i>p</i> = 0.005 and <i>p</i> = 0.020, respectively), whereas, high heart rate was present in patients with the rs462574<i>AA</i> genotype (<i>p</i> = 0.028). Our data suggest that the rs2298659, rs456298, and rs462574 polymorphisms independently and as haplotypes are associated with the risk of COVID-19. The rs456298 and rs462574 genotypes are related to high levels of LDH and heart rate.https://www.mdpi.com/1999-4915/14/9/1976COVID-19 diseasegenetic susceptibilitypolymorphismsSARS-CoV-2 infectiontransmembrane serine protease-2 (TMPRSS2) |
| spellingShingle | Rosalinda Posadas-Sánchez José Manuel Fragoso Fausto Sánchez-Muñoz Gustavo Rojas-Velasco Julian Ramírez-Bello Alberto López-Reyes Laura E. Martínez-Gómez Carlos Sierra-Fernández Tatiana Rodríguez-Reyna Nora Elemi Regino-Zamarripa Gustavo Ramírez-Martínez Joaquín Zuñiga-Ramos Gilberto Vargas-Alarcón Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19 Viruses COVID-19 disease genetic susceptibility polymorphisms SARS-CoV-2 infection transmembrane serine protease-2 (TMPRSS2) |
| title | Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19 |
| title_full | Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19 |
| title_fullStr | Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19 |
| title_full_unstemmed | Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19 |
| title_short | Association of the Transmembrane Serine Protease-2 (TMPRSS2) Polymorphisms with COVID-19 |
| title_sort | association of the transmembrane serine protease 2 tmprss2 polymorphisms with covid 19 |
| topic | COVID-19 disease genetic susceptibility polymorphisms SARS-CoV-2 infection transmembrane serine protease-2 (TMPRSS2) |
| url | https://www.mdpi.com/1999-4915/14/9/1976 |
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